Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican

doi:10.1083/jcb.141.5.1277

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© The Rockefeller University Press, 0021-9525/1998//1277 $5.00
The Journal of Cell Biology, Volume 141, Number 5, , 1998 1277-1286

Articles

Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican

Shukti Chakravarti^*, Terry Magnuson, Jonathan H. Lass, Karl J. Jepsen^||, Christian LaMantia, and Heidi Carroll^*

^* Department of Medicine and Genetics, Department of Genetics, Department of Ophthalmology, and ^|| Department of Orthopaedics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-4952

Lumican, a prototypic leucine-rich proteoglycan with keratansulfate side chains, is a major component of the cornea, dermal,and muscle connective tissues. Mice homozygous for a null mutationin lumican display skin laxity and fragility resembling certaintypes of Ehlers-Danlos syndrome. In addition, the mutant micedevelop bilateral corneal opacification. The underlying connectivetissue defect in the homozygous mutants is deregulated growthof collagen fibrils with a significant proportion of abnormallythick collagen fibrils in the skin and cornea as indicated by transmission electron microscopy. A highly organized and regularlyspaced collagen fibril matrix typical of the normal corneais also missing in these mutant mice. This study establishesa crucial role for lumican in the regulation of collagen assemblyinto fibrils in various connective tissues. Most importantly,these results provide a definitive link between a necessityfor lumican in the development of a highly organized collagenousmatrix and corneal transparency.

Abbreviations used in this paper: EDS, Ehlers-Danos syndrome; ES, embryonic stem; GAG, glycosaminoglycan; KS, keratan sulfate; LRP, leucine-rich proteoglycan family.

Address all correspondence to Shukti Chakravarti, Ph.D., Departmentsof Medicine and Genetics, School of Medicine, Case WesternReserve University, 10900 Euclid Avenue, Office: 423 BRB, Cleveland,OH 44106-4952. Tel.: (216) 368-1828. Fax: (216) 368-1674. E-mail:sxc76{at}po.cwru.edu

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Funderburgh, J. L., Funderburgh, M. L., Mann, M. M., Corpuz, L., Roth, M. R. (2001). Proteoglycan Expression during Transforming Growth Factor beta -induced Keratocyte-Myofibroblast Transdifferentiation. J. Biol. Chem. 276: 44173-44178 [Abstract] [Full Text]
Plaas, A. H., West, L. A., Thonar, E. J. A., Karcioglu, Z. A., Smith, C. J., Klintworth, G. K., Hascall, V. C. (2001). Altered Fine Structures of Corneal and Skeletal Keratan Sulfate and Chondroitin/Dermatan Sulfate in Macular Corneal Dystrophy. J. Biol. Chem. 276: 39788-39796 [Abstract] [Full Text]
Takanosu, M., Boyd, T. C., Le Goff, M., Henry, S. P., Zhang, Y., Bishop, P. N., Mayne, R. (2001). Structure, Chromosomal Location, and Tissue-Specific Expression of the Mouse Opticin Gene. IOVS 42: 2202-2210 [Abstract] [Full Text]
Quantock, A. J., Meek, K. M., Chakravarti, S. (2001). An X-ray Diffraction Investigation of Corneal Structure in Lumican-Deficient Mice. IOVS 42: 1750-1756 [Abstract] [Full Text]
Holmes, D. F., Gilpin, C. J., Baldock, C., Ziese, U., Koster, A. J., Kadler, K. E. (2001). Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization. Proc. Natl. Acad. Sci. USA 10.1073/pnas.111150598v1 [Abstract] [Full Text]
Pickering, J. G. (2001). Regulation of Vascular Cell Behavior by Collagen : Form Is Function. Circ. Res. 88: 458-459 [Full Text]
Ezura, Y., Chakravarti, S., Oldberg, A., Chervoneva, I., Birk, D. E. (2000). Differential Expression of Lumican and Fibromodulin Regulate Collagen Fibrillogenesis in Developing Mouse Tendons. JCB 151: 779-788 [Abstract] [Full Text]
Chakravarti, S., Petroll, W. M., Hassell, J. R., Jester, J. V., Lass, J. H., Paul, J., Birk, D. E. (2000). Corneal Opacity in Lumican-Null Mice: Defects in Collagen Fibril Structure and Packing in the Posterior Stroma. IOVS 41: 3365-3373 [Abstract] [Full Text]
Long, C. J., Roth, M. R., Tasheva, E. S., Funderburgh, M., Smit, R., Conrad, G. W., Funderburgh, J. L. (2000). Fibroblast Growth Factor-2 Promotes Keratan Sulfate Proteoglycan Expression by Keratocytes in Vitro. J. Biol. Chem. 275: 13918-13923 [Abstract] [Full Text]
Lewis, D., Davies, Y., Nieduszynski, I. A., Lawrence, F., Quantock, A. J., Bonshek, R., Fullwood, N. J. (2000). Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I. Glycobiology 10: 305-312 [Abstract] [Full Text]
Saika, S., Shiraishi, A., Saika, S., Liu, C.-Y., Funderburgh, J. L., Kao, C. W.-C., Converse, R. L., Kao, W. W.-Y. (2000). Role of Lumican in the Corneal Epithelium during Wound Healing. J. Biol. Chem. 275: 2607-2612 [Abstract] [Full Text]
Lander, A. D., Selleck, S. B. (2000). The Elusive Functions of Proteoglycans: In Vivo Veritas. JCB 148: 227-232 [Full Text]
Reardon, A. J., Le Goff, M., Briggs, M. D., McLeod, D., Sheehan, J. K., Thornton, D. J., Bishop, P. N. (2000). Identification in Vitreous and Molecular Cloning of Opticin, a Novel Member of the Family of Leucine-rich Repeat Proteins of the Extracellular Matrix. J. Biol. Chem. 275: 2123-2129 [Abstract] [Full Text]
Yoshioka, N., Inoue, H., Nakanishi, K., Oka, K., Yutsudo, M., Yamashita, A., Hakura, A., Nojima, H. (2000). Isolation of Transformation Suppressor Genes by cDNA Subtraction: Lumican Suppresses Transformation Induced by v-src and v-K-ras. J. Virol. 74: 1008-1013 [Abstract] [Full Text]
Iozzo, R. V. (1999). The Biology of the Small Leucine-rich Proteoglycans. FUNCTIONAL NETWORK OF INTERACTIVE PROTEINS. J. Biol. Chem. 274: 18843-18846 [Full Text]
Beales, M. P., Funderburgh, J. L., Jester, J. V., Hassell, J. R. (1999). Proteoglycan Synthesis by Bovine Keratocytes and Corneal Fibroblasts: Maintenance of the Keratocyte Phenotype in Culture. IOVS 40: 1658-1663 [Abstract] [Full Text]
Tasheva, E. S., Funderburgh, M. L., McReynolds, J., Funderburgh, J. L., Conrad, G. W. (1999). The Bovine Mimecan Gene. MOLECULAR CLONING AND CHARACTERIZATION OF TWO MAJOR RNA TRANSCRIPTS GENERATED BY ALTERNATIVE USE OF TWO SPLICE ACCEPTOR SITES IN THE THIRD EXON. J. Biol. Chem. 274: 18693-18701 [Abstract] [Full Text]
Yang, V. W-C, LaBrenz, S. R., Rosenberg, L. C., McQuillan, D., Hook, M. (1999). Decorin Is a Zn2+ Metalloprotein. J. Biol. Chem. 274: 12454-12460 [Abstract] [Full Text]
Svensson, L., Aszodi, A., Reinholt, F. P., Fassler, R., Heinegard, D., Oldberg, A. (1999). Fibromodulin-null Mice Have Abnormal Collagen Fibrils, Tissue Organization, and Altered Lumican Deposition in Tendon. J. Biol. Chem. 274: 9636-9647 [Abstract] [Full Text]
Grover, J., Liu, C.-Y., Kao, W. W.-Y., Roughley, P. J. (2000). Analysis of the Human Lumican Gene Promoter. J. Biol. Chem. 275: 40967-40973 [Abstract] [Full Text]
Lorenzo, P., Aspberg, A., Onnerfjord, P., Bayliss, M. T., Neame, P. J., Heinegard, D. (2001). Identification and Characterization of Asporin. A NOVEL MEMBER OF THE LEUCINE-RICH REPEAT PROTEIN FAMILY CLOSELY RELATED TO DECORIN AND BIGLYCAN. J. Biol. Chem. 276: 12201-12211 [Abstract] [Full Text]
Henry, S. P., Takanosu, M., Boyd, T. C., Mayne, P. M., Eberspaecher, H., Zhou, W., de Crombrugghe, B., Hook, M., Mayne, R. (2001). Expression Pattern and Gene Characterization of Asporin. A NEWLY DISCOVERED MEMBER OF THE LEUCINE-RICH REPEAT PROTEIN FAMILY. J. Biol. Chem. 276: 12212-12221 [Abstract] [Full Text]
Mansson, B., Wenglen, C., Morgelin, M., Saxne, T., Heinegard, D. (2001). Association of Chondroadherin with Collagen Type II. J. Biol. Chem. 276: 32883-32888 [Abstract] [Full Text]
Pluen, A., Boucher, Y., Ramanujan, S., McKee, T. D., Gohongi, T., di Tomaso, E., Brown, E. B., Izumi, Y., Campbell, R. B., Berk, D. A., Jain, R. K. (2001). Role of tumor-host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors. Proc. Natl. Acad. Sci. USA 98: 4628-4633 [Abstract] [Full Text]
Holmes, D. F., Gilpin, C. J., Baldock, C., Ziese, U., Koster, A. J., Kadler, K. E. (2001). Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization. Proc. Natl. Acad. Sci. USA 98: 7307-7312 [Abstract] [Full Text]