J. Cell Biol., Volume 141, Number 5, June 1, 1998 1277-1286

Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican

Shukti Chakravarti,^* Terry Magnuson, Jonathan H. Lass,^§ Karl J. Jepsen, Christian LaMantia, and Heidi Carroll^*

^* Department of Medicine and Genetics,  Department of Genetics, ^§ Department of Ophthalmology, and  Department of Orthopaedics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-4952

Lumican, a prototypic leucine-rich proteoglycan with keratan sulfate side chains, is a major component of the cornea, dermal, and muscle connective tissues. Mice homozygous for a null mutation in lumican display skin laxity and fragility resembling certain types of Ehlers-Danlos syndrome. In addition, the mutant mice develop bilateral corneal opacification. The underlying connective tissue defect in the homozygous mutants is deregulated growth of collagen fibrils with a significant proportion of abnormally thick collagen fibrils in the skin and cornea as indicated by transmission electron microscopy. A highly organized and regularly spaced collagen fibril matrix typical of the normal cornea is also missing in these mutant mice. This study establishes a crucial role for lumican in the regulation of collagen assembly into fibrils in various connective tissues. Most importantly, these results provide a definitive link between a necessity for lumican in the development of a highly organized collagenous matrix and corneal transparency.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Soderberg, M. W., Bystrom, B., Kalamajski, S., Malmstrom, A., Ekman-Ordeberg, G. (2009). Gene expressions of small leucine-rich repeat proteoglycans and fibulin-5 are decreased in pelvic organ prolapse. Mol Hum Reprod 15: 251-257 [Abstract] [Full Text]  
• Ansorge, H. L., Meng, X., Zhang, G., Veit, G., Sun, M., Klement, J. F., Beason, D. P., Soslowsky, L. J., Koch, M., Birk, D. E. (2009). Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE. J. Biol. Chem. 284: 8427-8438 [Abstract] [Full Text]  
• Zhang, G., Chen, S., Goldoni, S., Calder, B. W., Simpson, H. C., Owens, R. T., McQuillan, D. J., Young, M. F., Iozzo, R. V., Birk, D. E. (2009). Genetic Evidence for the Coordinated Regulation of Collagen Fibrillogenesis in the Cornea by Decorin and Biglycan. J. Biol. Chem. 284: 8888-8897 [Abstract] [Full Text]  
• Kalamajski, S., Oldberg, A. (2009). Homologous Sequence in Lumican and Fibromodulin Leucine-rich Repeat 5-7 Competes for Collagen Binding. J. Biol. Chem. 284: 534-539 [Abstract] [Full Text]  
• Schaefer, L., Iozzo, R. V. (2008). Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction. J. Biol. Chem. 283: 21305-21309 [Abstract] [Full Text]  
• Magzoub, M., Jin, S., Verkman, A. S. (2008). Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 22: 276-284 [Abstract] [Full Text]  
• Carlson, E. C., Lin, M., Liu, C.-Y., Kao, W. W-Y., Perez, V. L., Pearlman, E. (2007). Keratocan and Lumican Regulate Neutrophil Infiltration and Corneal Clarity in Lipopolysaccharide-induced Keratitis by Direct Interaction with CXCL1. J. Biol. Chem. 282: 35502-35509 [Abstract] [Full Text]  
• Wu, F., Chakravarti, S. (2007). Differential Expression of Inflammatory and Fibrogenic Genes and Their Regulation by NF-{kappa}B Inhibition in a Mouse Model of Chronic Colitis. J. Immunol. 179: 6988-7000 [Abstract] [Full Text]  
• Kalamajski, S., Oldberg, A. (2007). Fibromodulin Binds Collagen Type I via Glu-353 and Lys-355 in Leucine-rich Repeat 11. J. Biol. Chem. 282: 26740-26745 [Abstract] [Full Text]  
• Wu, F., Vij, N., Roberts, L., Lopez-Briones, S., Joyce, S., Chakravarti, S. (2007). A Novel Role of the Lumican Core Protein in Bacterial Lipopolysaccharide-induced Innate Immune Response. J. Biol. Chem. 282: 26409-26417 [Abstract] [Full Text]  
• Guo, X., Hutcheon, A. E. K., Melotti, S. A., Zieske, J. D., Trinkaus-Randall, V., Ruberti, J. W. (2007). Morphologic Characterization of Organized Extracellular Matrix Deposition by Ascorbic Acid Stimulated Human Corneal Fibroblasts. IOVS 48: 4050-4060 [Abstract] [Full Text]  
• Jester, J. V., Lee, Y. G., Huang, J., Houston, J., Adams, B., Cavanagh, H. D., Petroll, W. M. (2007). Postnatal Corneal Transparency, Keratocyte Cell Cycle Exit and Expression of ALDH1A1. IOVS 48: 4061-4069 [Abstract] [Full Text]  
• Kalamajski, S., Aspberg, A., Oldberg, A. (2007). The Decorin Sequence SYIRIADTNIT Binds Collagen Type I. J. Biol. Chem. 282: 16062-16067 [Abstract] [Full Text]  
• Takaluoma, K., Hyry, M., Lantto, J., Sormunen, R., Bank, R. A., Kivirikko, K. I., Myllyharju, J., Soininen, R. (2007). Tissue-specific Changes in the Hydroxylysine Content and Cross-links of Collagens and Alterations in Fibril Morphology in Lysyl Hydroxylase 1 Knock-out Mice. J. Biol. Chem. 282: 6588-6596 [Abstract] [Full Text]  
• Dugan, T. A., Yang, V. W.-C., McQuillan, D. J., Hook, M. (2006). Decorin Modulates Fibrin Assembly and Structure. J. Biol. Chem. 281: 38208-38216 [Abstract] [Full Text]  
• Musselmann, K., Kane, B., Alexandrou, B., Hassell, J. R. (2006). Stimulation of Collagen Synthesis by Insulin and Proteoglycan Accumulation by Ascorbate in Bovine Keratocytes In Vitro. IOVS 47: 5260-5266 [Abstract] [Full Text]  
• Hayashida, Y., Akama, T. O., Beecher, N., Lewis, P., Young, R. D., Meek, K. M., Kerr, B., Hughes, C. E., Caterson, B., Tanigami, A., Nakayama, J., Fukada, M. N., Tano, Y., Nishida, K., Quantock, A. J. (2006). Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase. Proc. Natl. Acad. Sci. USA 103: 13333-13338 [Abstract] [Full Text]  
• Cooper, L. J., Bentley, A. J., Nieduszynski, I. A., Talabani, S., Thomson, A., Utani, A., Shinkai, H., Fullwood, N. J., Brown, G. M. (2006). The role of dermatopontin in the stromal organization of the cornea.. IOVS 47: 3303-3310 [Abstract] [Full Text]  
• Conrad, A. H., Zhang, Y., Walker, A. R., Olberding, L. A., Hanzlick, A., Zimmer, A. J., Morffi, R., Conrad, G. W. (2006). Thyroxine Affects Expression of KSPG-Related Genes, the Carbonic Anhydrase II Gene, and KS Sulfation in the Embryonic Chicken Cornea. IOVS 47: 120-132 [Abstract] [Full Text]  
• Beecher, N., Chakravarti, S., Joyce, S., Meek, K. M., Quantock, A. J. (2006). Neonatal Development of the Corneal Stroma in Wild-Type and Lumican-Null Mice. IOVS 47: 146-150 [Abstract] [Full Text]  
• Beecher, N., Carlson, C., Allen, B. R., Kipchumba, R., Conrad, G. W., Meek, K. M., Quantock, A. J. (2005). An X-Ray Diffraction Study of Corneal Structure in Mimecan-Deficient Mice. IOVS 46: 4046-4049 [Abstract] [Full Text]  
• Naitoh, M., Kubota, H., Ikeda, M., Tanaka, T., Shirane, H., Suzuki, S., Nagata, K. (2005). Gene expression in human keloids is altered from dermal to chondrocytic and osteogenic lineage. GENES CELLS 10: 1081-1091 [Abstract] [Full Text]  
• Musselmann, K., Alexandrou, B., Kane, B., Hassell, J. R. (2005). Maintenance of the Keratocyte Phenotype during Cell Proliferation Stimulated by Insulin. J. Biol. Chem. 280: 32634-32639 [Abstract] [Full Text]  
• Hopfer, U., Fukai, N., Hopfer, H., Wolf, G., Joyce, N., Li, E., Olsen, B. R. (2005). Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye. FASEB J. 19: 1232-1244 [Abstract] [Full Text]  
• Carlson, E. C., Liu, C.-Y., Chikama, T.-i., Hayashi, Y., Kao, C. W.-C., Birk, D. E., Funderburgh, J. L., Jester, J. V., Kao, W. W.-Y. (2005). Keratocan, a Cornea-specific Keratan Sulfate Proteoglycan, Is Regulated by Lumican. J. Biol. Chem. 280: 25541-25547 [Abstract] [Full Text]  
• Young, R. D., Tudor, D., Hayes, A. J., Kerr, B., Hayashida, Y., Nishida, K., Meek, K. M., Caterson, B., Quantock, A. J. (2005). Atypical Composition and Ultrastructure of Proteoglycans in the Mouse Corneal Stroma. IOVS 46: 1973-1978 [Abstract] [Full Text]  
• Docheva, D., Hunziker, E. B., Fassler, R., Brandau, O. (2005). Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation. Mol. Cell. Biol. 25: 699-705 [Abstract] [Full Text]  
• Vij, N., Roberts, L., Joyce, S., Chakravarti, S. (2005). Lumican Regulates Corneal Inflammatory Responses by Modulating Fas-Fas Ligand Signaling. IOVS 46: 88-95 [Abstract] [Full Text]  
• Chakravarti, S., Wu, F., Vij, N., Roberts, L., Joyce, S. (2004). Microarray Studies Reveal Macrophage-like Function of Stromal Keratocytes in the Cornea. IOVS 45: 3475-3484 [Abstract] [Full Text]  
• Ge, G., Seo, N.-S., Liang, X., Hopkins, D. R., Hook, M., Greenspan, D. S. (2004). Bone Morphogenetic Protein-1/Tolloid-related Metalloproteinases Process Osteoglycin and Enhance Its Ability to Regulate Collagen Fibrillogenesis. J. Biol. Chem. 279: 41626-41633 [Abstract] [Full Text]  
• Schaefer, L., Mihalik, D., Babelova, A., Krzyzankova, M., Grone, H.-J., Iozzo, R. V., Young, M. F., Seidler, D. G., Lin, G., Reinhardt, D. P., Schaefer, R. M. (2004). Regulation of Fibrillin-1 by Biglycan and Decorin Is Important for Tissue Preservation in the Kidney During Pressure-Induced Injury. Am. J. Pathol. 165: 383-396 [Abstract] [Full Text]  
• Jokinen, J., Dadu, E., Nykvist, P., Kapyla, J., White, D. J., Ivaska, J., Vehvilainen, P., Reunanen, H., Larjava, H., Hakkinen, L., Heino, J. (2004). Integrin-mediated Cell Adhesion to Type I Collagen Fibrils. J. Biol. Chem. 279: 31956-31963 [Abstract] [Full Text]  
• Espana, E. M., He, H., Kawakita, T., Di Pascuale, M. A., Raju, V. K., Liu, C.-Y., Tseng, S. C. G. (2003). Human Keratocytes Cultured on Amniotic Membrane Stroma Preserve Morphology and Express Keratocan. IOVS 44: 5136-5141 [Abstract] [Full Text]  
• Li, S., Van Den Diepstraten, C., D'Souza, S. J., Chan, B. M. C., Pickering, J. G. (2003). Vascular Smooth Muscle Cells Orchestrate the Assembly of Type I Collagen via {alpha}2{beta}1 Integrin, RhoA, and Fibronectin Polymerization. Am. J. Pathol. 163: 1045-1056 [Abstract] [Full Text]  
• Ross, M. D., Bruggeman, L. A., Hanss, B., Sunamoto, M., Marras, D., Klotman, M. E., Klotman, P. E. (2003). Podocan, a Novel Small Leucine-rich Repeat Protein Expressed in the Sclerotic Glomerular Lesion of Experimental HIV-associated Nephropathy. J. Biol. Chem. 278: 33248-33255 [Abstract] [Full Text]  
• Chakravarti, S., Paul, J., Roberts, L., Chervoneva, I., Oldberg, A., Birk, D. E. (2003). Ocular and Scleral Alterations in Gene-Targeted Lumican-Fibromodulin Double-Null Mice. IOVS 44: 2422-2432 [Abstract] [Full Text]  
• Saika, S., Miyamoto, T., Tanaka, S.-i., Tanaka, T., Ishida, I., Ohnishi, Y., Ooshima, A., Ishiwata, T., Asano, G., Chikama, T.-i., Shiraishi, A., Liu, C.-Y., Kao, C. W.-C., Kao, W. W.-Y. (2003). Response of Lens Epithelial Cells to Injury: Role of Lumican in Epithelial-Mesenchymal Transition. IOVS 44: 2094-2102 [Abstract] [Full Text]  
• Dugan, T. A., Yang, V. W-C., McQuillan, D. J., Hook, M. (2003). Decorin Binds Fibrinogen in a Zn2+-dependent Interaction. J. Biol. Chem. 278: 13655-13662 [Abstract] [Full Text]  
• Song, J., Lee, Y.-G., Houston, J., Petroll, W. M., Chakravarti, S., Cavanagh, H. D., Jester, J. V. (2003). Neonatal Corneal Stromal Development in the Normal and Lumican-Deficient Mouse. IOVS 44: 548-557 [Abstract] [Full Text]  
• Troup, S., Njue, C., Kliewer, E. V., Parisien, M., Roskelley, C., Chakravarti, S., Roughley, P. J., Murphy, L. C., Watson, P. H. (2003). Reduced Expression of the Small Leucine-rich Proteoglycans, Lumican, and Decorin Is Associated with Poor Outcome in Node-negative Invasive Breast Cancer. Clin. Cancer Res. 9: 207-214 [Abstract] [Full Text]  
• Wiberg, C., Heinegard, D., Wenglen, C., Timpl, R., Morgelin, M. (2002). Biglycan Organizes Collagen VI into Hexagonal-like Networks Resembling Tissue Structures. J. Biol. Chem. 277: 49120-49126 [Abstract] [Full Text]  
• Berryhill, B. L., Kader, R., Kane, B., Birk, D. E., Feng, J., Hassell, J. R. (2002). Partial Restoration of the Keratocyte Phenotype to Bovine Keratocytes Made Fibroblastic by Serum. IOVS 43: 3416-3421 [Abstract] [Full Text]  
• Akama, T. O., Misra, A. K., Hindsgaul, O., Fukuda, M. N. (2002). Enzymatic Synthesis in Vitro of the Disulfated Disaccharide Unit of Corneal Keratan Sulfate. J. Biol. Chem. 277: 42505-42513 [Abstract] [Full Text]  
• Jepsen, K. J., Wu, F., Peragallo, J. H., Paul, J., Roberts, L., Ezura, Y., Oldberg, A., Birk, D. E., Chakravarti, S. (2002). A Syndrome of Joint Laxity and Impaired Tendon Integrity in Lumican- and Fibromodulin-deficient Mice. J. Biol. Chem. 277: 35532-35540 [Abstract] [Full Text]  
• Ameye, L., Young, M. F. (2002). Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases. Glycobiology 12: 107R-116R [Abstract] [Full Text]  
• AMEYE, L., ARIA, D., JEPSEN, K., OLDBERG, A., XU, T., YOUNG, M. F. (2002). Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis. FASEB J. 16: 673-680 [Abstract] [Full Text]  
• Schaefer, L., Macakova, K., Raslik, I., Micegova, M., Grone, H.-J., Schonherr, E., Robenek, H., Echtermeyer, F. G., Grassel, S., Bruckner, P., Schaefer, R. M., Iozzo, R. V., Kresse, H. (2002). Absence of Decorin Adversely Influences Tubulointerstitial Fibrosis of the Obstructed Kidney by Enhanced Apoptosis and Increased Inflammatory Reaction. Am. J. Pathol. 160: 1181-1191 [Abstract] [Full Text]  
• Akhtar, S., Tullo, A., Caterson, B., Davies, J. R, Bennett, K., Meek, K. M (2002). Clinical and morphological features including expression of {beta}ig-h3 and keratan sulphate proteoglycans in Maroteaux-Lamy syndrome type B and in normal cornea. Br. J. Ophthalmol. 86: 147-151 [Abstract] [Full Text]  
• Funderburgh, J. L., Funderburgh, M. L., Mann, M. M., Corpuz, L., Roth, M. R. (2001). Proteoglycan Expression during Transforming Growth Factor beta -induced Keratocyte-Myofibroblast Transdifferentiation. J. Biol. Chem. 276: 44173-44178 [Abstract] [Full Text]  
• Plaas, A. H., West, L. A., Thonar, E. J. A., Karcioglu, Z. A., Smith, C. J., Klintworth, G. K., Hascall, V. C. (2001). Altered Fine Structures of Corneal and Skeletal Keratan Sulfate and Chondroitin/Dermatan Sulfate in Macular Corneal Dystrophy. J. Biol. Chem. 276: 39788-39796 [Abstract] [Full Text]  
• Takanosu, M., Boyd, T. C., Le Goff, M., Henry, S. P., Zhang, Y., Bishop, P. N., Mayne, R. (2001). Structure, Chromosomal Location, and Tissue-Specific Expression of the Mouse Opticin Gene. IOVS 42: 2202-2210 [Abstract] [Full Text]  
• Quantock, A. J., Meek, K. M., Chakravarti, S. (2001). An X-ray Diffraction Investigation of Corneal Structure in Lumican-Deficient Mice. IOVS 42: 1750-1756 [Abstract] [Full Text]  
• Holmes, D. F., Gilpin, C. J., Baldock, C., Ziese, U., Koster, A. J., Kadler, K. E. (2001). Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization. Proc. Natl. Acad. Sci. USA 10.1073/pnas.111150598v1 [Abstract] [Full Text]  
• Pluen, A., Boucher, Y., Ramanujan, S., McKee, T. D., Gohongi, T., di Tomaso, E., Brown, E. B., Izumi, Y., Campbell, R. B., Berk, D. A., Jain, R. K. (2001). Role of tumor-host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors. Proc. Natl. Acad. Sci. USA 10.1073/pnas.081626898v1 [Abstract] [Full Text]  
• Pickering, J. G. (2001). Regulation of Vascular Cell Behavior by Collagen : Form Is Function. Circ. Res. 88: 458-459 [Full Text]  
• Ezura, Y., Chakravarti, S., Oldberg, A., Chervoneva, I., Birk, D. E. (2000). Differential Expression of Lumican and Fibromodulin Regulate Collagen Fibrillogenesis in Developing Mouse Tendons. JCB 151: 779-788 [Abstract] [Full Text]  
• Chakravarti, S., Petroll, W. M., Hassell, J. R., Jester, J. V., Lass, J. H., Paul, J., Birk, D. E. (2000). Corneal Opacity in Lumican-Null Mice: Defects in Collagen Fibril Structure and Packing in the Posterior Stroma. IOVS 41: 3365-3373 [Abstract] [Full Text]  
• Long, C. J., Roth, M. R., Tasheva, E. S., Funderburgh, M., Smit, R., Conrad, G. W., Funderburgh, J. L. (2000). Fibroblast Growth Factor-2 Promotes Keratan Sulfate Proteoglycan Expression by Keratocytes in Vitro. J. Biol. Chem. 275: 13918-13923 [Abstract] [Full Text]  
• Lewis, D., Davies, Y., Nieduszynski, I. A., Lawrence, F., Quantock, A. J., Bonshek, R., Fullwood, N. J. (2000). Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular corneal dystrophy type I. Glycobiology 10: 305-312 [Abstract] [Full Text]  
• Saika, S., Shiraishi, A., Saika, S., Liu, C.-Y., Funderburgh, J. L., Kao, C. W.-C., Converse, R. L., Kao, W. W.-Y. (2000). Role of Lumican in the Corneal Epithelium during Wound Healing. J. Biol. Chem. 275: 2607-2612 [Abstract] [Full Text]  
• Lander, A. D., Selleck, S. B. (2000). The Elusive Functions of Proteoglycans: In Vivo Veritas. JCB 148: 227-232 [Abstract] [Full Text]  
• Reardon, A. J., Le Goff, M., Briggs, M. D., McLeod, D., Sheehan, J. K., Thornton, D. J., Bishop, P. N. (2000). Identification in Vitreous and Molecular Cloning of Opticin, a Novel Member of the Family of Leucine-rich Repeat Proteins of the Extracellular Matrix. J. Biol. Chem. 275: 2123-2129 [Abstract] [Full Text]  
• Yoshioka, N., Inoue, H., Nakanishi, K., Oka, K., Yutsudo, M., Yamashita, A., Hakura, A., Nojima, H. (2000). Isolation of Transformation Suppressor Genes by cDNA Subtraction: Lumican Suppresses Transformation Induced by v-src and v-K-ras. J. Virol. 74: 1008-1013 [Abstract] [Full Text]  
• Iozzo, R. V. (1999). The Biology of the Small Leucine-rich Proteoglycans. FUNCTIONAL NETWORK OF INTERACTIVE PROTEINS. J. Biol. Chem. 274: 18843-18846 [Full Text]  
• Beales, M. P., Funderburgh, J. L., Jester, J. V., Hassell, J. R. (1999). Proteoglycan Synthesis by Bovine Keratocytes and Corneal Fibroblasts: Maintenance of the Keratocyte Phenotype in Culture. IOVS 40: 1658-1663 [Abstract] [Full Text]  
• Tasheva, E. S., Funderburgh, M. L., McReynolds, J., Funderburgh, J. L., Conrad, G. W. (1999). The Bovine Mimecan Gene. MOLECULAR CLONING AND CHARACTERIZATION OF TWO MAJOR RNA TRANSCRIPTS GENERATED BY ALTERNATIVE USE OF TWO SPLICE ACCEPTOR SITES IN THE THIRD EXON. J. Biol. Chem. 274: 18693-18701 [Abstract] [Full Text]  
• Yang, V. W-C, LaBrenz, S. R., Rosenberg, L. C., McQuillan, D., Hook, M. (1999). Decorin Is a Zn2+ Metalloprotein. J. Biol. Chem. 274: 12454-12460 [Abstract] [Full Text]  
• Svensson, L., Aszodi, A., Reinholt, F. P., Fassler, R., Heinegard, D., Oldberg, A. (1999). Fibromodulin-null Mice Have Abnormal Collagen Fibrils, Tissue Organization, and Altered Lumican Deposition in Tendon. J. Biol. Chem. 274: 9636-9647 [Abstract] [Full Text]  
• Grover, J., Liu, C.-Y., Kao, W. W.-Y., Roughley, P. J. (2000). Analysis of the Human Lumican Gene Promoter. J. Biol. Chem. 275: 40967-40973 [Abstract] [Full Text]  
• Lorenzo, P., Aspberg, A., Onnerfjord, P., Bayliss, M. T., Neame, P. J., Heinegard, D. (2001). Identification and Characterization of Asporin. A NOVEL MEMBER OF THE LEUCINE-RICH REPEAT PROTEIN FAMILY CLOSELY RELATED TO DECORIN AND BIGLYCAN. J. Biol. Chem. 276: 12201-12211 [Abstract] [Full Text]  
• Henry, S. P., Takanosu, M., Boyd, T. C., Mayne, P. M., Eberspaecher, H., Zhou, W., de Crombrugghe, B., Hook, M., Mayne, R. (2001). Expression Pattern and Gene Characterization of Asporin. A NEWLY DISCOVERED MEMBER OF THE LEUCINE-RICH REPEAT PROTEIN FAMILY. J. Biol. Chem. 276: 12212-12221 [Abstract] [Full Text]  
• Mansson, B., Wenglen, C., Morgelin, M., Saxne, T., Heinegard, D. (2001). Association of Chondroadherin with Collagen Type II. J. Biol. Chem. 276: 32883-32888 [Abstract] [Full Text]  
• Pluen, A., Boucher, Y., Ramanujan, S., McKee, T. D., Gohongi, T., di Tomaso, E., Brown, E. B., Izumi, Y., Campbell, R. B., Berk, D. A., Jain, R. K. (2001). Role of tumor-host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors. Proc. Natl. Acad. Sci. USA 98: 4628-4633 [Abstract] [Full Text]  
• Holmes, D. F., Gilpin, C. J., Baldock, C., Ziese, U., Koster, A. J., Kadler, K. E. (2001). Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization. Proc. Natl. Acad. Sci. USA 98: 7307-7312 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents