© The Rockefeller University Press,
0021-9525/1998//1713 $5.00
The Journal of Cell Biology, Volume 143, Number 6,
, 1998 1713-1723
Roles for Laminin in Embryogenesis: Exencephaly, Syndactyly, and Placentopathy in Mice Lacking the Laminin
5 Chain
Jeffrey H. Miner*,
Jeanette Cunningham
, and
Joshua R. Sanes
* Department of Medicine, Renal Division and
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110
Laminins are the major noncollagenous glycoproteins of all basal laminae (BLs). They are
/β/
heterotrimers assembled from 10 known chains, and they subserve both structural and signaling roles. Previously described mutations in laminin chain genes result in diverse disorders that are manifested postnatally and therefore provide little insight into laminin's roles in embryonic development. Here, we show that the laminin
5 chain is required during embryogenesis. The
5 chain is present in virtually all BLs of early somite stage embryos and then becomes restricted to specific BLs as development proceeds, including those of the surface ectoderm and placental vasculature. BLs that lose
5 retain or acquire other
chains. Embryos lacking laminin
5 die late in embryogenesis. They exhibit multiple developmental defects, including failure of anterior neural tube closure (exencephaly), failure of digit septation (syndactyly), and dysmorphogenesis of the placental labyrinth. These defects are all attributable to defects in BLs that are
5 positive in controls and that appear ultrastructurally abnormal in its absence. Other laminin
chains accumulate in these BLs, but this compensation is apparently functionally inadequate. Our results identify new roles for laminins and BLs in diverse developmental processes.
Key Words: basement membrane development placenta knockout mice limb deformities
Abbreviations used in this paper: AER, apical ectodermal ridge; BL, basal lamina; BrdU, 5-bromo-2'-deoxy-uridine; E, embryonic day.

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-
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-
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-
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[Full Text]
-
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-
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[Abstract]
[Full Text]
-
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[Abstract]
[Full Text]
-
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[Abstract]
[Full Text]
-
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[Abstract]
[Full Text]
-
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(2005). Protein Kinase A-dependent Phosphorylation of Lutheran/Basal Cell Adhesion Molecule Glycoprotein Regulates Cell Adhesion to Laminin {alpha}5. J. Biol. Chem.
280: 30055-30062
[Abstract]
[Full Text]
-
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(2005). Compound Genetic Ablation of Nidogen 1 and 2 Causes Basement Membrane Defects and Perinatal Lethality in Mice. Mol. Cell. Biol.
25: 6846-6856
[Abstract]
[Full Text]
-
Niewmierzycka, A., Mills, J., St-Arnaud, R., Dedhar, S., Reichardt, L. F.
(2005). Integrin-Linked Kinase Deletion from Mouse Cortex Results in Cortical Lamination Defects Resembling Cobblestone Lissencephaly. J. Neurosci.
25: 7022-7031
[Abstract]
[Full Text]
-
Hallmann, R., Horn, N., Selg, M., Wendler, O., Pausch, F., Sorokin, L. M.
(2005). Expression and Function of Laminins in the Embryonic and Mature Vasculature. Physiol. Rev.
85: 979-1000
[Abstract]
[Full Text]
-
Watson, E. D., Cross, J. C.
(2005). Development of Structures and Transport Functions in the Mouse Placenta. Physiology
20: 180-193
[Abstract]
[Full Text]
-
Miner, J. H.
(2005). Building the Glomerulus: A Matricentric View. J. Am. Soc. Nephrol.
16: 857-861
[Full Text]
-
Yang, D., Bierman, J., Tarumi, Y. S., Zhong, Y.-P., Rangwala, R., Proctor, T. M., Miyagoe-Suzuki, Y., Takeda, S., Miner, J. H., Sherman, L. S., Gold, B. G., Patton, B. L.
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168: 655-666
[Abstract]
[Full Text]
-
Yu, W., Datta, A., Leroy, P., O'Brien, L. E., Mak, G., Jou, T.-S., Matlin, K. S., Mostov, K. E., Zegers, M. M.P.
(2005). {beta}1-Integrin Orients Epithelial Polarity via Rac1 and Laminin. Mol. Biol. Cell
16: 433-445
[Abstract]
[Full Text]
-
Schmid, R. S., Shelton, S., Stanco, A., Yokota, Y., Kreidberg, J. A., Anton, E. S.
(2004). {alpha}3{beta}1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development. Development
131: 6023-6031
[Abstract]
[Full Text]
-
Odenthal, U., Haehn, S., Tunggal, P., Merkl, B., Schomburg, D., Frie, C., Paulsson, M., Smyth, N.
(2004). Molecular Analysis of Laminin N-terminal Domains Mediating Self-interactions. J. Biol. Chem.
279: 44504-44512
[Abstract]
[Full Text]
-
Gawlik, K., Miyagoe-Suzuki, Y., Ekblom, P., Takeda, S., Durbeej, M.
(2004). Laminin {alpha}1 chain reduces muscular dystrophy in laminin {alpha}2 chain deficient mice. Hum Mol Genet
13: 1775-1784
[Abstract]
[Full Text]
-
Dixelius, J., Jakobsson, L., Genersch, E., Bohman, S., Ekblom, P., Claesson-Welsh, L.
(2004). Laminin-1 Promotes Angiogenesis in Synergy with Fibroblast Growth Factor by Distinct Regulation of the Gene and Protein Expression Profile in Endothelial Cells. J. Biol. Chem.
279: 23766-23772
[Abstract]
[Full Text]
-
Miner, J. H., Li, C., Mudd, J. L., Go, G., Sutherland, A. E.
(2004). Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation. Development
131: 2247-2256
[Abstract]
[Full Text]
-
Poschl, E., Schlotzer-Schrehardt, U., Brachvogel, B., Saito, K., Ninomiya, Y., Mayer, U.
(2004). Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development
131: 1619-1628
[Abstract]
[Full Text]
-
Sasaki, T., Fassler, R., Hohenester, E.
(2004). Laminin: the crux of basement membrane assembly. JCB
164: 959-963
[Abstract]
[Full Text]
-
Ido, H., Harada, K., Futaki, S., Hayashi, Y., Nishiuchi, R., Natsuka, Y., Li, S., Wada, Y., Combs, A. C., Ervasti, J. M., Sekiguchi, K.
(2004). Molecular Dissection of the {alpha}-Dystroglycan- and Integrin-binding Sites within the Globular Domain of Human Laminin-10. J. Biol. Chem.
279: 10946-10954
[Abstract]
[Full Text]
-
Huang, C.-c., Hall, D. H., Hedgecock, E. M., Kao, G., Karantza, V., Vogel, B. E., Hutter, H., Chisholm, A. D., Yurchenco, P. D., Wadsworth, W. G.
(2003). Laminin {alpha} subunits and their role in C. elegans development. Development
130: 3343-3358
[Abstract]
[Full Text]
-
Chen, Z.-L., Indyk, J. A., Strickland, S.
(2003). The Hippocampal Laminin Matrix Is Dynamic and Critical for Neuronal Survival. Mol. Biol. Cell
14: 2665-2676
[Abstract]
[Full Text]
-
Ferletta, M., Kikkawa, Y., Yu, H., Talts, J. F., Durbeej, M., Sonnenberg, A., Timpl, R., Campbell, K. P., Ekblom, P., Genersch, E.
(2003). Opposing Roles of Integrin {alpha}6A{beta}1 and Dystroglycan in Laminin-mediated Extracellular Signal-regulated Kinase Activation. Mol. Biol. Cell
14: 2088-2103
[Abstract]
[Full Text]
-
Cachaco, A. S., Chuva de Sousa Lopes, S. M., Kuikman, I., Bajanca, F., Abe, K., Baudoin, C., Sonnenberg, A., Mummery, C. L., Thorsteinsdottir, S.
(2003). Knock-in of integrin {beta}1D affects primary but not secondary myogenesis in mice. Development
130: 1659-1671
[Abstract]
[Full Text]
-
Kikkawa, Y., Virtanen, I., Miner, J. H.
(2003). Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin {alpha}5 in the glomerular basement membrane. JCB
161: 187-196
[Abstract]
[Full Text]
-
Hoffman, M. P., Kidder, B. L., Steinberg, Z. L., Lakhani, S., Ho, S., Kleinman, H. K., Larsen, M.
(2003). Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development
129: 5767-5778
[Abstract]
[Full Text]
-
Schmid, R. S., Anton, E.S.
(2003). Role of Integrins in the Development of the Cerebral Cortex. Cereb Cortex
13: 219-224
[Abstract]
[Full Text]
-
Gu, Y.-C., Kortesmaa, J., Tryggvason, K., Persson, J., Ekblom, P., Jacobsen, S.-E., Ekblom, M.
(2003). Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. Blood
101: 877-885
[Abstract]
[Full Text]
-
Kikkawa, Y., Moulson, C. L., Virtanen, I., Miner, J. H.
(2002). Identification of the Binding Site for the Lutheran Blood Group Glycoprotein on Laminin alpha 5 through Expression of Chimeric Laminin Chains in Vivo. J. Biol. Chem.
277: 44864-44869
[Abstract]
[Full Text]
-
Schymeinsky, J., Nedbal, S., Miosge, N., Poschl, E., Rao, C., Beier, D. R., Skarnes, W. C., Timpl, R., Bader, B. L.
(2002). Gene Structure and Functional Analysis of the Mouse Nidogen-2 Gene: Nidogen-2 Is Not Essential for Basement Membrane Formation in Mice. Mol. Cell. Biol.
22: 6820-6830
[Abstract]
[Full Text]
-
Natoli, T. A., Liu, J., Eremina, V., Hodgens, K., Li, C., Hamano, Y., Mundel, P., Kalluri, R., Miner, J. H., Quaggin, S. E., Kreidberg, J. A.
(2002). A Mutant Form of the Wilms' Tumor Suppressor Gene WT1 Observed in Denys-Drash Syndrome Interferes with Glomerular Capillary Development. J. Am. Soc. Nephrol.
13: 2058-2067
[Abstract]
[Full Text]
-
Halfter, W., Dong, S., Yip, Y.-P., Willem, M., Mayer, U.
(2002). A Critical Function of the Pial Basement Membrane in Cortical Histogenesis. J. Neurosci.
22: 6029-6040
[Abstract]
[Full Text]
-
Doi, M., Thyboll, J., Kortesmaa, J., Jansson, K., Iivanainen, A., Parvardeh, M., Timpl, R., Hedin, U., Swedenborg, J., Tryggvason, K.
(2002). Recombinant Human Laminin-10 (alpha 5beta 1gamma 1). PRODUCTION, PURIFICATION, AND MIGRATION-PROMOTING ACTIVITY ON VASCULAR ENDOTHELIAL CELLS. J. Biol. Chem.
277: 12741-12748
[Abstract]
[Full Text]
-
Thyboll, J., Kortesmaa, J., Cao, R., Soininen, R., Wang, L., Iivanainen, A., Sorokin, L., Risling, M., Cao, Y., Tryggvason, K.
(2002). Deletion of the Laminin {alpha}4 Chain Leads to Impaired Microvessel Maturation. Mol. Cell. Biol.
22: 1194-1202
[Abstract]
[Full Text]
-
Debeer, P, Schoenmakers, E F P M, Twal, W O, Argraves, W S, De Smet, L, Fryns, J-P, Van de Ven, W J M
(2002). The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly. J. Med. Genet.
39: 98-104
[Abstract]
[Full Text]
-
Willem, M., Miosge, N., Halfter, W., Smyth, N., Jannetti, I., Burghart, E., Timpl, R., Mayer, U.
(2002). Specific ablation of the nidogen-binding site in the laminin {gamma}1 chain interferes with kidney and lung development. Development
129: 2711-2722
[Abstract]
[Full Text]
-
Bouvard, D., Brakebusch, C., Gustafsson, E., Aszodi, A., Bengtsson, T., Berna, A., Fassler, R.
(2001). Functional Consequences of Integrin Gene Mutations in Mice. Circ. Res.
89: 211-223
[Abstract]
[Full Text]
-
St. John, P. L., Wang, R., Yin, Y., Miner, J. H., Robert, B., Abrahamson, D. R.
(2001). Glomerular laminin isoform transitions: errors in metanephric culture are corrected by grafting. Am. J. Physiol. Renal Physiol.
280: F695-F705
[Abstract]
[Full Text]
-
Georgiades, P., Watkins, M., Burton, G. J., Ferguson-Smith, A. C.
(2001). Roles for genomic imprinting and the zygotic genome in placental development. Proc. Natl. Acad. Sci. USA
10.1073/pnas.081540898v1
[Abstract]
[Full Text]
-
Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., Davis, G. E.
(2001). Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J. Cell Sci.
114: 2755-2773
[Abstract]
[Full Text]
-
Siler, U., Seiffert, M., Puch, S., Richards, A., Torok-Storb, B., Muller, C. A., Sorokin, L., Klein, G.
(2000). Characterization and functional analysis of laminin isoforms in human bone marrow. Blood
96: 4194-4203
[Abstract]
[Full Text]
-
Murshed, M., Smyth, N., Miosge, N., Karolat, J., Krieg, T., Paulsson, M., Nischt, R.
(2000). The Absence of Nidogen 1 Does Not Affect Murine Basement Membrane Formation. Mol. Cell. Biol.
20: 7007-7012
[Abstract]
[Full Text]
-
Andrews, K. L., Betsuyaku, T., Rogers, S., Shipley, J. M., Senior, R. M., Miner, J. H.
(2000). Gelatinase B (MMP-9) Is Not Essential in the Normal Kidney and Does Not Influence Progression of Renal Disease in a Mouse Model of Alport Syndrome. Am. J. Pathol.
157: 303-311
[Abstract]
[Full Text]
-
Nielsen, P. K., Gho, Y. S., Hoffman, M. P., Watanabe, H., Makino, M., Nomizu, M., Yamada, Y.
(2000). Identification of a Major Heparin and Cell Binding Site in the LG4 Module of the Laminin alpha 5 Chain. J. Biol. Chem.
275: 14517-14523
[Abstract]
[Full Text]
-
Juriloff, D. M., Harris, M. J.
(2000). Mouse models for neural tube closure defects. Hum Mol Genet
9: 993-1000
[Abstract]
[Full Text]
-
Brouns, M., Matheson, S., Hu, K., Delalle, I, Caviness, V., Silver, J, Bronson, R., Settleman, J
(2000). The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development
127: 4891-4903
[Abstract]
-
Kikkawa, Y, Sanzen, N, Fujiwara, H, Sonnenberg, A, Sekiguchi, K
(2000). Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins. J. Cell Sci.
113: 869-876
[Abstract]
-
Costell, M., Gustafsson, E., Aszodi, A., Morgelin, M., Bloch, W., Hunziker, E., Addicks, K., Timpl, R., Fassler, R.
(1999). Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes. JCB
147: 1109-1122
[Abstract]
[Full Text]
-
Colognato, H., Winkelmann, D. A., Yurchenco, P. D.
(1999). Laminin Polymerization Induces a Receptor-Cytoskeleton Network. JCB
145: 619-631
[Abstract]
[Full Text]
-
De Arcangelis, A, Mark, M, Kreidberg, J, Sorokin, L, Georges-Labouesse, E
(1999). Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse. Development
126: 3957-3968
[Abstract]
-
Nielsen, P. K., Yamada, Y.
(2001). Identification of Cell-binding Sites on the Laminin alpha 5 N-terminal Domain by Site-directed Mutagenesis. J. Biol. Chem.
276: 10906-10912
[Abstract]
[Full Text]
-
Gu, J., Sumida, Y., Sanzen, N., Sekiguchi, K.
(2001). Laminin-10/11 and Fibronectin Differentially Regulate Integrin- dependent Rho and Rac Activation via p130Cas-CrkII-DOCK180 Pathway. J. Biol. Chem.
276: 27090-27097
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-
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