© The Rockefeller University Press,
0021-9525/1998//1871 $5.00
The Journal of Cell Biology, Volume 143, Number 7,
, 1998 1871-1881
Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms
Yoram Altschuler
,
Shana M. Barbas*,
Laura J. Terlecky*,
Kitty Tang
,
Stephen Hardy
,
Keith E. Mostov
, and
Sandra L. Schmid*
* Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037;
Department of Anatomy, University of California, San Francisco, California 94143; and
Cell Genesys Inc., Foster City, California 94404
A role for dynamin in clathrin-mediated endocytosis is now well established. However, mammals express three closely related, tissue-specific dynamin isoforms, each with multiple splice variants. Thus, an important question is whether these isoforms and splice variants function in vesicle formation from distinct intracellular organelles. There are conflicting data as to a role for dynamin-2 in vesicle budding from the TGN. To resolve this issue, we compared the effects of overexpression of dominant-negative mutants of dynamin-1 (the neuronal isoform) and dynamin-2 (the ubiquitously expressed isoform) on endocytic and biosynthetic membrane trafficking in HeLa cells and polarized MDCK cells. Both dyn1(K44A) and dyn2(K44A) were potent inhibitors of receptor-mediated endocytosis; however neither mutant directly affected other membrane trafficking events, including transport mediated by four distinct classes of vesicles budding from the TGN. Dyn2(K44A) more potently inhibited receptor-mediated endocytosis than dyn1(K44A) in HeLa cells and at the basolateral surface of MDCK cells. In contrast, dyn1(K44A) more potently inhibited endocytosis at the apical surface of MDCK cells. The two dynamin isoforms have redundant functions in endocytic vesicle formation, but can be targeted to and function differentially at subdomains of the plasma membrane.
Key Words: receptor-mediated endocytosis dynamin polarized MDCK cells trans-Golgi network adenovirus expression
Abbreviations used in this paper: B-Tfn, biotinylated-transferrin; dyn1, dynamin-1; dyn2, dynamin-2; GFP, green fluorescent protein; MPR, cation-independent mannose-6-phosphate receptor; Tfn, transferrin.

CiteULike
Complore
Connotea
Del.icio.us
Digg
Facebook
Reddit
Technorati
Twitter What's this?
This article has been cited by other articles:
-
Huang, Y.-W., Su, P., Liu, G. Y., Crow, M. R., Chaukos, D., Yan, H., Robinson, L. A.
(2009). Constitutive Endocytosis of the Chemokine CX3CL1 Prevents Its Degradation by Cell Surface Metalloproteases. J. Biol. Chem.
284: 29644-29653
[Abstract]
[Full Text]
-
Clemente, R., de la Torre, J. C.
(2009). Cell Entry of Borna Disease Virus Follows a Clathrin-Mediated Endocytosis Pathway That Requires Rab5 and Microtubules. J. Virol.
83: 10406-10416
[Abstract]
[Full Text]
-
Padovano, V., Massari, S., Mazzucchelli, S., Pietrini, G.
(2009). PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells. Am. J. Physiol. Cell Physiol.
297: C835-C844
[Abstract]
[Full Text]
-
Kolpak, A. L., Jiang, J., Guo, D., Standley, C., Bellve, K., Fogarty, K., Bao, Z.-Z.
(2009). Negative Guidance Factor-Induced Macropinocytosis in the Growth Cone Plays a Critical Role in Repulsive Axon Turning. J. Neurosci.
29: 10488-10498
[Abstract]
[Full Text]
-
Douglas, J. L., Viswanathan, K., McCarroll, M. N., Gustin, J. K., Fruh, K., Moses, A. V.
(2009). Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a {beta}TrCP-Dependent Mechanism. J. Virol.
83: 7931-7947
[Abstract]
[Full Text]
-
Molle, D., Segura-Morales, C., Camus, G., Berlioz-Torrent, C., Kjems, J., Basyuk, E., Bertrand, E.
(2009). Endosomal Trafficking of HIV-1 Gag and Genomic RNAs Regulates Viral Egress. J. Biol. Chem.
284: 19727-19743
[Abstract]
[Full Text]
-
Bruzzaniti, A., Neff, L., Sandoval, A., Du, L., Horne, W. C., Baron, R.
(2009). Dynamin Reduces Pyk2 Y402 Phosphorylation and Src Binding in Osteoclasts. Mol. Cell. Biol.
29: 3644-3656
[Abstract]
[Full Text]
-
Bu, W., Chou, A. M., Lim, K. B., Sudhaharan, T., Ahmed, S.
(2009). The Toca-1-N-WASP Complex Links Filopodial Formation to Endocytosis. J. Biol. Chem.
284: 11622-11636
[Abstract]
[Full Text]
-
Chiasson, C. M., Wittich, K. B., Vincent, P. A., Faundez, V., Kowalczyk, A. P.
(2009). p120-Catenin Inhibits VE-Cadherin Internalization through a Rho-independent Mechanism. Mol. Biol. Cell
20: 1970-1980
[Abstract]
[Full Text]
-
Bernatchez, P. N., Sharma, A., Kodaman, P., Sessa, W. C.
(2009). Myoferlin is critical for endocytosis in endothelial cells. Am. J. Physiol. Cell Physiol.
297: C484-C492
[Abstract]
[Full Text]
-
Liu, Y.-W., Surka, M. C., Schroeter, T., Lukiyanchuk, V., Schmid, S. L.
(2008). Isoform and Splice-Variant Specific Functions of Dynamin-2 Revealed by Analysis of Conditional Knock-Out Cells. Mol. Biol. Cell
19: 5347-5359
[Abstract]
[Full Text]
-
Vassilieva, E. V., Gerner-Smidt, K., Ivanov, A. I., Nusrat, A.
(2008). Lipid rafts mediate internalization of {beta}1-integrin in migrating intestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol.
295: G965-G976
[Abstract]
[Full Text]
-
Kumari, S., Borroni, V., Chaudhry, A., Chanda, B., Massol, R., Mayor, S., Barrantes, F. J.
(2008). Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway. JCB
181: 1179-1193
[Abstract]
[Full Text]
-
Huang, C.-Y., Lu, T.-Y., Bair, C.-H., Chang, Y.-S., Jwo, J.-K., Chang, W.
(2008). A Novel Cellular Protein, VPEF, Facilitates Vaccinia Virus Penetration into HeLa Cells through Fluid Phase Endocytosis. J. Virol.
82: 7988-7999
[Abstract]
[Full Text]
-
Pandey, M. S., Harris, E. N., Weigel, J. A., Weigel, P. H.
(2008). The Cytoplasmic Domain of the Hyaluronan Receptor for Endocytosis (HARE) Contains Multiple Endocytic Motifs Targeting Coated Pit-mediated Internalization. J. Biol. Chem.
283: 21453-21461
[Abstract]
[Full Text]
-
McFarland, M. J., Bardell, T. K., Yates, M. L., Placzek, E. A., Barker, E. L.
(2008). RNA Interference-Mediated Knockdown of Dynamin 2 Reduces Endocannabinoid Uptake into Neuronal dCAD Cells. Mol. Pharmacol.
74: 101-108
[Abstract]
[Full Text]
-
Delva, E., Jennings, J. M., Calkins, C. C., Kottke, M. D., Faundez, V., Kowalczyk, A. P.
(2008). Pemphigus Vulgaris IgG-induced Desmoglein-3 Endocytosis and Desmosomal Disassembly Are Mediated by a Clathrin- and Dynamin-independent Mechanism. J. Biol. Chem.
283: 18303-18313
[Abstract]
[Full Text]
-
Zhang, A.-S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedson, T., Bjorkman, P. J., Enns, C. A.
(2008). Neogenin-mediated Hemojuvelin Shedding Occurs after Hemojuvelin Traffics to the Plasma Membrane. J. Biol. Chem.
283: 17494-17502
[Abstract]
[Full Text]
-
Saavedra, L., Mohamed, A., Ma, V., Kar, S., de Chaves, E. P.
(2007). Internalization of -Amyloid Peptide by Primary Neurons in the Absence of Apolipoprotein E. J. Biol. Chem.
282: 35722-35732
[Abstract]
[Full Text]
-
Cao, H., Chen, J., Awoniyi, M., Henley, J. R., McNiven, M. A.
(2007). Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells. J. Cell Sci.
120: 4167-4177
[Abstract]
[Full Text]
-
Baumgartner, P., Geiger, M., Zieseniss, S., Malleier, J., Huntington, J. A., Hochrainer, K., Bielek, E., Stoeckelhuber, M., Lauber, K., Scherfeld, D., Schwille, P., Waldele, K., Beyer, K., Engelmann, B.
(2007). Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor. JCB
179: 793-804
[Abstract]
[Full Text]
-
Zemskov, E. A., Mikhailenko, I., Strickland, D. K., Belkin, A. M.
(2007). Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1. J. Cell Sci.
120: 3188-3199
[Abstract]
[Full Text]
-
Dorsey, F. C., Muthusamy, T., Whitt, M. A., Cox, J. V.
(2007). A novel role for a YXX{Phi} motif in directing the caveolin-dependent sorting of membrane-spanning proteins. J. Cell Sci.
120: 2544-2554
[Abstract]
[Full Text]
-
Zhang, J., Vinuela, A., Neely, M. H., Hallett, P. J., Grant, S. G. N., Miller, G. M., Isacson, O., Caron, M. G., Yao, W.-D.
(2007). Inhibition of the Dopamine D1 Receptor Signaling by PSD-95. J. Biol. Chem.
282: 15778-15789
[Abstract]
[Full Text]
-
Shmuel, M., Nodel-Berner, E., Hyman, T., Rouvinski, A., Altschuler, Y.
(2007). Caveolin 2 Regulates Endocytosis and Trafficking of the M1 Muscarinic Receptor in MDCK Epithelial Cells. Mol. Biol. Cell
18: 1570-1585
[Abstract]
[Full Text]
-
Pizzato, M., Helander, A., Popova, E., Calistri, A., Zamborlini, A., Palu, G., Gottlinger, H. G.
(2007). Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc. Natl. Acad. Sci. USA
104: 6812-6817
[Abstract]
[Full Text]
-
Kierbel, A., Gassama-Diagne, A., Rocha, C., Radoshevich, L., Olson, J., Mostov, K., Engel, J.
(2007). Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane. JCB
177: 21-27
[Abstract]
[Full Text]
-
Kang-Decker, N., Cao, S., Chatterjee, S., Yao, J., Egan, L. J., Semela, D., Mukhopadhyay, D., Shah, V.
(2007). Nitric oxide promotes endothelial cell survival signaling through S-nitrosylation and activation of dynamin-2. J. Cell Sci.
120: 492-501
[Abstract]
[Full Text]
-
Seto, E. S., Bellen, H. J.
(2006). Internalization is required for proper Wingless signaling in Drosophila melanogaster.. JCB
173: 95-106
[Abstract]
[Full Text]
-
Ivanov, V. N., Ronai, Z., Hei, T. K.
(2006). Opposite Roles of FAP-1 and Dynamin in the Regulation of Fas (CD95) Translocation to the Cell Surface and Susceptibility to Fas Ligand-mediated Apoptosis. J. Biol. Chem.
281: 1840-1852
[Abstract]
[Full Text]
-
Hyman, T., Shmuel, M., Altschuler, Y.
(2006). Actin Is Required for Endocytosis at the Apical Surface of Madin-Darby Canine Kidney Cells where ARF6 and Clathrin Regulate the Actin Cytoskeleton. Mol. Biol. Cell
17: 427-437
[Abstract]
[Full Text]
-
Lagana, A., Goetz, J. G., Y, N., Altschuler, Y., Nabi, I. R.
(2005). pH-specific sequestration of phosphoglucose isomerase/autocrine motility factor by fibronectin and heparan sulphate. J. Cell Sci.
118: 4175-4185
[Abstract]
[Full Text]
-
Shen, L., Turner, J. R.
(2005). Actin Depolymerization Disrupts Tight Junctions via Caveolae-mediated Endocytosis. Mol. Biol. Cell
16: 3919-3936
[Abstract]
[Full Text]
-
Janvier, K., Bonifacino, J. S.
(2005). Role of the Endocytic Machinery in the Sorting of Lysosome-associated Membrane Proteins. Mol. Biol. Cell
16: 4231-4242
[Abstract]
[Full Text]
-
Bruzzaniti, A., Neff, L., Sanjay, A., Horne, W. C., De Camilli, P., Baron, R.
(2005). Dynamin Forms a Src Kinase-sensitive Complex with Cbl and Regulates Podosomes and Osteoclast Activity. Mol. Biol. Cell
16: 3301-3313
[Abstract]
[Full Text]
-
Solomaha, E., Szeto, F. L., Yousef, M. A., Palfrey, H. C.
(2005). Kinetics of Src Homology 3 Domain Association with the Proline-rich Domain of Dynamins: SPECIFICITY, OCCLUSION, AND THE EFFECTS OF PHOSPHORYLATION. J. Biol. Chem.
280: 23147-23156
[Abstract]
[Full Text]
-
Soulet, F., Yarar, D., Leonard, M., Schmid, S. L.
(2005). SNX9 Regulates Dynamin Assembly and Is Required for Efficient Clathrin-mediated Endocytosis. Mol. Biol. Cell
16: 2058-2067
[Abstract]
[Full Text]
-
Paing, M. M., Temple, B. R. S., Trejo, J.
(2004). A Tyrosine-based Sorting Signal Regulates Intracellular Trafficking of Protease-activated Receptor-1: MULTIPLE REGULATORY MECHANISMS FOR AGONIST-INDUCED G PROTEIN-COUPLED RECEPTOR INTERNALIZATION. J. Biol. Chem.
279: 21938-21947
[Abstract]
[Full Text]
-
Song, B. D., Yarar, D., Schmid, S. L.
(2004). An Assembly-incompetent Mutant Establishes a Requirement for Dynamin Self-assembly in Clathrin-mediated Endocytosis In Vivo. Mol. Biol. Cell
15: 2243-2252
[Abstract]
[Full Text]
-
Schlunck, G., Damke, H., Kiosses, W. B., Rusk, N., Symons, M. H., Waterman-Storer, C. M., Schmid, S. L., Schwartz, M. A.
(2004). Modulation of Rac Localization and Function by Dynamin. Mol. Biol. Cell
15: 256-267
[Abstract]
[Full Text]
-
Chyung, J. H., Selkoe, D. J.
(2003). Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid {beta}-Protein at the Cell Surface. J. Biol. Chem.
278: 51035-51043
[Abstract]
[Full Text]
-
Sneddon, W. B., Syme, C. A., Bisello, A., Magyar, C. E., Rochdi, M. D., Parent, J.-L., Weinman, E. J., Abou-Samra, A. B., Friedman, P. A.
(2003). Activation-independent Parathyroid Hormone Receptor Internalization Is Regulated by NHERF1 (EBP50). J. Biol. Chem.
278: 43787-43796
[Abstract]
[Full Text]
-
Conner, S. D., Schmid, S. L.
(2003). Differential requirements for AP-2 in clathrin-mediated endocytosis. JCB
162: 773-780
[Abstract]
[Full Text]
-
Touret, N., Furuya, W., Forbes, J., Gros, P., Grinstein, S.
(2003). Dynamic Traffic through the Recycling Compartment Couples the Metal Transporter Nramp2 (DMT1) with the Transferrin Receptor. J. Biol. Chem.
278: 25548-25557
[Abstract]
[Full Text]
-
Cobbold, C., Coventry, J., Ponnambalam, S., Monaco, A. P.
(2003). The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway. Hum Mol Genet
12: 1523-1533
[Abstract]
[Full Text]
-
TUMA, P. L., HUBBARD, A. L.
(2003). Transcytosis: Crossing Cellular Barriers. Physiol. Rev.
83: 871-932
[Abstract]
[Full Text]
-
Lipschutz, J. H., Lingappa, V. R., Mostov, K. E.
(2003). The Exocyst Affects Protein Synthesis by Acting on the Translocation Machinery of the Endoplasmic Reticulum. J. Biol. Chem.
278: 20954-20960
[Abstract]
[Full Text]
-
Fischer, R. S., Fritz-Six, K. L., Fowler, V. M.
(2003). Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility. JCB
161: 371-380
[Abstract]
[Full Text]
-
Muro, S., Wiewrodt, R., Thomas, A., Koniaris, L., Albelda, S. M., Muzykantov, V. R., Koval, M.
(2003). A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1. J. Cell Sci.
116: 1599-1609
[Abstract]
[Full Text]
-
Fourgeaud, L., Bessis, A.-S., Rossignol, F., Pin, J.-P., Olivo-Marin, J.-C., Hemar, A.
(2003). The Metabotropic Glutamate Receptor mGluR5 Is Endocytosed by a Clathrin-independent Pathway. J. Biol. Chem.
278: 12222-12230
[Abstract]
[Full Text]
-
Chies, R., Nobbio, L., Edomi, P., Schenone, A., Schneider, C., Brancolini, C.
(2003). Alterations in the Arf6-regulated plasma membrane endosomal recycling pathway in cells overexpressing the tetraspan protein Gas3/PMP22. J. Cell Sci.
116: 987-999
[Abstract]
[Full Text]
-
Le, P. U., Nabi, I. R.
(2003). Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum. J. Cell Sci.
116: 1059-1071
[Abstract]
[Full Text]
-
Rappoport, J. Z., Simon, S. M.
(2003). Real-time analysis of clathrin-mediated endocytosis during cell migration. J. Cell Sci.
116: 847-855
[Abstract]
[Full Text]
-
Efendiev, R., Yudowski, G. A., Zwiller, J., Leibiger, B., Katz, A. I., Berggren, P.-O., Pedemonte, C. H., Leibiger, I. B., Bertorello, A. M.
(2002). Relevance of Dopamine Signals Anchoring Dynamin-2 to the Plasma Membrane during Na+,K+-ATPase Endocytosis. J. Biol. Chem.
277: 44108-44114
[Abstract]
[Full Text]
-
Zeng, W.-Z., Babich, V., Ortega, B., Quigley, R., White, S. J., Welling, P. A., Huang, C.-L.
(2002). Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am. J. Physiol. Renal Physiol.
283: F630-F639
[Abstract]
[Full Text]
-
Zhou, G., Roizman, B.
(2002). Cation-Independent Mannose 6-Phosphate Receptor Blocks Apoptosis Induced by Herpes Simplex Virus 1 Mutants Lacking Glycoprotein D and Is Likely the Target of Antiapoptotic Activity of the Glycoprotein. J. Virol.
76: 6197-6204
[Abstract]
[Full Text]
-
Artalejo, C. R., Elhamdani, A., Palfrey, H. C.
(2002). Sustained stimulation shifts the mechanism of endocytosis from dynamin-1-dependent rapid endocytosis to clathrin- and dynamin-2-mediated slow endocytosis in chromaffin cells. Proc. Natl. Acad. Sci. USA
99: 6358-6363
[Abstract]
[Full Text]
-
Le, P. U., Guay, G., Altschuler, Y., Nabi, I. R.
(2002). Caveolin-1 Is a Negative Regulator of Caveolae-mediated Endocytosis to the Endoplasmic Reticulum. J. Biol. Chem.
277: 3371-3379
[Abstract]
[Full Text]
-
Blumstein, J., Faundez, V., Nakatsu, F., Saito, T., Ohno, H., Kelly, R. B.
(2001). The Neuronal Form of Adaptor Protein-3 Is Required for Synaptic Vesicle Formation from Endosomes. J. Neurosci.
21: 8034-8042
[Abstract]
[Full Text]
-
Damke, H., Binns, D. D., Ueda, H., Schmid, S. L., Baba, T.
(2001). Dynamin GTPase Domain Mutants Block Endocytic Vesicle Formation at Morphologically Distinct Stages. Mol. Biol. Cell
12: 2578-2589
[Abstract]
[Full Text]
-
McMillan, T. N., Johnson, D. C.
(2001). Cytoplasmic Domain of Herpes Simplex Virus gE Causes Accumulation in the trans-Golgi Network, a Site of Virus Envelopment and Sorting of Virions to Cell Junctions. J. Virol.
75: 1928-1940
[Abstract]
[Full Text]
-
Newmyer, S. L., Schmid, S. L.
(2001). Dominant-Interfering Hsc70 Mutants Disrupt Multiple Stages of the Clathrin-Coated Vesicle Cycle in Vivo. JCB
152: 607-620
[Abstract]
[Full Text]
-
Gáborik, Z., Szaszák, M., Szidonya, L., Balla, B., Paku, S., Catt, K. J., Clark, A. J. L., Hunyady, L.
(2001). {beta}-Arrestin- and Dynamin-Dependent Endocytosis of the AT1 Angiotensin Receptor. Mol. Pharmacol.
59: 239-247
[Abstract]
[Full Text]
-
York, R. D., Molliver, D. C., Grewal, S. S., Stenberg, P. E., McCleskey, E. W., Stork, P. J. S.
(2000). Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1. Mol. Cell. Biol.
20: 8069-8083
[Abstract]
[Full Text]
-
Okamoto, C. T., Duman, J. G., Tyagarajan, K., McDonald, K. L., Jeng, Y. Y., McKinney, J., Forte, T. M., Forte, J. G.
(2000). Clathrin in gastric acid secretory (parietal) cells: biochemical characterization and subcellular localization. Am. J. Physiol. Cell Physiol.
279: C833-C851
[Abstract]
[Full Text]
-
Fish, K. N., Schmid, S. L., Damke, H.
(2000). Evidence That Dynamin-2 Functions as a Signal-Transducing Gtpase. JCB
150: 145-154
[Abstract]
[Full Text]
-
Kao, A. W., Yang, C., Pessin, J. E.
(2000). Functional comparison of the role of dynamin 2 splice variants on GLUT-4 endocytosis in 3T3L1 adipocytes. Am. J. Physiol. Endocrinol. Metab.
278: E825-E831
[Abstract]
[Full Text]
-
Contamin, S., Galmiche, A., Doye, A., Flatau, G., Benmerah, A., Boquet, P.
(2000). The p21 Rho-activating Toxin Cytotoxic Necrotizing Factor 1 Is Endocytosed by a Clathrin-independent Mechanism and Enters the Cytosol by an Acidic-dependent Membrane Translocation Step. Mol. Biol. Cell
11: 1775-1787
[Abstract]
[Full Text]
-
Altschuler, Y., Kinlough, C. L., Poland, P. A., Bruns, J. B., Apodaca, G., Weisz, O. A., Hughey, R. P.
(2000). Clathrin-mediated Endocytosis of MUC1 Is Modulated by Its Glycosylation State. Mol. Biol. Cell
11: 819-831
[Abstract]
[Full Text]
-
Nicoziani, P., Vilhardt, F., Llorente, A., Hilout, L., Courtoy, P. J., Sandvig, K., van Deurs, B.
(2000). Role for Dynamin in Late Endosome Dynamics and Trafficking of the Cation-independent Mannose 6-Phosphate Receptor. Mol. Biol. Cell
11: 481-495
[Abstract]
[Full Text]
-
Cao, H, Thompson, H., Krueger, E., McNiven, M.
(2000). Disruption of Golgi structure and function in mammalian cells expressing a mutant dynamin. J. Cell Sci.
113: 1993-2002
[Abstract]
-
Duan, D., Li, Q., Kao, A. W., Yue, Y., Pessin, J. E., Engelhardt, J. F.
(1999). Dynamin Is Required for Recombinant Adeno-Associated Virus Type 2 Infection. J. Virol.
73: 10371-10376
[Abstract]
[Full Text]
-
Carroll, R. C., Beattie, E. C., Xia, H., Luscher, C., Altschuler, Y., Nicoll, R. A., Malenka, R. C., von Zastrow, M.
(1999). Dynamin-dependent endocytosis of ionotropic glutamate receptors. Proc. Natl. Acad. Sci. USA
96: 14112-14117
[Abstract]
[Full Text]
-
Altschuler, Y., Liu, S.-H., Katz, L., Tang, K., Hardy, S., Brodsky, F., Apodaca, G., Mostov, K.
(1999). Adp-Ribosylation Factor 6 and Endocytosis at the Apical Surface of Madin-Darby Canine Kidney Cells. JCB
147: 7-12
[Abstract]
[Full Text]
-
Page, L. J., Sowerby, P. J., Lui, W. W.Y., Robinson, M. S.
(1999). {gamma}-Synergin: An Eh Domain-Containing Protein That Interacts with {gamma}-Adaptin. JCB
146: 993-1004
[Abstract]
[Full Text]
-
Nishimura, N., Bannykh, S., Slabough, S., Matteson, J., Altschuler, Y., Hahn, K., Balch, W. E.
(1999). A Di-acidic (DXE) Code Directs Concentration of Cargo during Export from the Endoplasmic Reticulum. J. Biol. Chem.
274: 15937-15946
[Abstract]
[Full Text]
-
Bunemann, M., Hosey, M M.
(1999). G-protein coupled receptor kinases as modulators of G-protein signalling. J. Physiol.
517: 5-23
[Abstract]
[Full Text]
-
Quinones, B, Riento, K, Olkkonen, V., Hardy, S, Bennett, M.
(1999). Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations. J. Cell Sci.
112: 4291-4304
[Abstract]
-
Collazo, R., Fan, L., Hu, M. C., Zhao, H., Wiederkehr, M. R., Moe, O. W.
(2000). Acute Regulation of Na+/H+ Exchanger NHE3 by Parathyroid Hormone via NHE3 Phosphorylation and Dynamin-dependent Endocytosis. J. Biol. Chem.
275: 31601-31608
[Abstract]
[Full Text]
-
Baron, V., Schwartz, M.
(2000). Cell Adhesion Regulates Ubiquitin-mediated Degradation of the Platelet-derived Growth Factor Receptor beta. J. Biol. Chem.
275: 39318-39323
[Abstract]
[Full Text]
-
Trejo, J., Altschuler, Y., Fu, H.-W., Mostov, K. E., Coughlin, S. R.
(2000). Protease-activated Receptor-1 Down-regulation. A MUTANT HeLa CELL LINE SUGGESTS NOVEL REQUIREMENTS FOR PAR1 PHOSPHORYLATION AND RECRUITMENT TO CLATHRIN-COATED PITS. J. Biol. Chem.
275: 31255-31265
[Abstract]
[Full Text]
-
Yang, Z., Li, H., Chai, Z., Fullerton, M. J., Cao, Y., Toh, B.-H., Funder, J. W., Liu, J.-P.
(2001). Dynamin II Regulates Hormone Secretion in Neuroendocrine Cells. J. Biol. Chem.
276: 4251-4260
[Abstract]
[Full Text]
-
Paing, M. M., Stutts, A. B., Kohout, T. A., Lefkowitz, R. J., Trejo, J.
(2002). beta -Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation. J. Biol. Chem.
277: 1292-1300
[Abstract]
[Full Text]
-
Craven, S. E., Bredt, D. S.
(2000). Synaptic Targeting of the Postsynaptic Density Protein PSD-95 Mediated by a Tyrosine-based Trafficking Signal. J. Biol. Chem.
275: 20045-20051
[Abstract]
[Full Text]
-
Artalejo, C. R., Elhamdani, A., Palfrey, H. C.
(2002). Sustained stimulation shifts the mechanism of endocytosis from dynamin-1-dependent rapid endocytosis to clathrin- and dynamin-2-mediated slow endocytosis in chromaffin cells. Proc. Natl. Acad. Sci. USA
99: 6358-6363
[Abstract]
[Full Text]
-
van Dam, E. M., Stoorvogel, W.
(2002). Dynamin-dependent Transferrin Receptor Recycling by Endosome-derived Clathrin-coated Vesicles. Mol. Biol. Cell
13: 169-182
[Abstract]
[Full Text]