Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast.

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© The Rockefeller University Press, 0021-9525/1998//1931 $5.00
The Journal of Cell Biology, Volume 143, Number 7, , 1998 1931-1945

Research Support, U.S. Gov't, P.H.S.

Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast.

D W Pruyne, D H Schott, and A Bretscher

The actin cytoskeleton in budding yeast consists of corticalpatches and cables, both of which polarize toward regions ofcell growth. Tropomyosin localizes specifically to actin cablesand not cortical patches. Upon shifting cells with conditionallydefective tropomyosin to restrictive temperatures, actin cablesdisappear within 1 min and both the unconventional class V myosinMyo2p and the secretory vesicle-associated Rab GTPase Sec4pdepolarize rapidly. Bud growth ceases and the mother cell growsisotropically. When returned to permissive temperatures, tropomyosin-containingcables reform within 1 min in polarized arrays. Cable reassemblypermits rapid enrichment of Myo2p at the focus of nascent cablesas well as the Myo2p- dependent recruitment of Sec4p and theexocyst protein Sec8p, and the initiation of bud emergence.With the loss of actin cables, cortical patches slowly assumean isotropic distribution within the cell and will repolarizeonly after restoration of cables. Therefore, actin cables respondto polarity cues independently of the overall distribution ofcortical patches and are able to directly target the Myo2p-dependentdelivery of secretory vesicles and polarization of growth.

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