© The Rockefeller University Press,
0021-9525/1999//891 $5.00
The Journal of Cell Biology, Volume 144, Number 5,
, 1999 891-901
Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis
Solange Desagher,
Astrid Osen-Sand,
Anthony Nichols,
Robert Eskes,
Sylvie Montessuit,
Sandra Lauper,
Kinsey Maundrell,
Bruno Antonsson, and
Jean-Claude Martinou
Serono Pharmaceutical Research Institute, Ares-Serono International S.A., CH-1228 Plan-les-Ouates, Geneva, Switzerland
Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria. This event is associated with a change in conformation of Bax which leads to the unmasking of its NH2-terminal domain and is accompanied by the release of cytochrome c from mitochondria. A similar finding is reported for cerebellar granule cells undergoing apoptosis induced by serum and potassium deprivation. The Bax-conformational change is prevented by Bcl-2 and Bcl-xL but not by caspase inhibitors. Using isolated mitochondria and various BH3 mutants of Bid, we demonstrate that direct binding of Bid to Bax is a prerequisite for Bax structural change and cytochrome c release. Bcl-xL can inhibit the effect of Bid by interacting directly with Bax. Moreover, using mitochondria from Bax-deficient tumor cell lines, we show that Bid- induced release of cytochrome c is negligible when Bid is added alone, but dramatically increased when Bid and Bax are added together. Taken together, our results suggest that, during certain types of apoptosis, Bid translocates to mitochondria and binds to Bax, leading to a change in conformation of Bax and to cytochrome c release from mitochondria.
Key Words: apoptosis Bax Bid cytochrome c mitochondria
Abbreviations used in this paper: BH, Bcl-2 homology; CGC, cerebellar granule cells; COX-IV, cytochrome oxidase subunit IV; HM, heavy membrane; MB, mitochondrial buffer; mt-hsp-70, mitochondrial heat shock protein 70.
Part of this work was funded by the European Community (Biotech grant BIO4CT96 0774 to Jean-Claude Martinou).

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-
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-
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-
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[Full Text]
-
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-
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-
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-
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-
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[Full Text]
-
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21: 1937-1948
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[Full Text]
-
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-
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-
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[Abstract]
[Full Text]
-
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[Full Text]
-
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[Full Text]
-
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(2007). Interleukin-4 induces human hepatocyte apoptosis through a Fas-independent pathway. FASEB J.
21: 1433-1444
[Abstract]
[Full Text]
-
Hussain, A. R., Al-Jomah, N. A., Siraj, A. K., Manogaran, P., Al-Hussein, K., Abubaker, J., Platanias, L. C., Al-Kuraya, K. S., Uddin, S.
(2007). Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells. Cancer Res.
67: 3888-3897
[Abstract]
[Full Text]
-
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(2007). Mitogen-Activated Protein Kinase Kinase Inhibition Enhances Nuclear Proapoptotic Function of p53 in Acute Myelogenous Leukemia Cells. Cancer Res.
67: 3210-3219
[Abstract]
[Full Text]
-
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[Abstract]
[Full Text]
-
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6: 484-495
[Abstract]
[Full Text]
-
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(2007). Bid-Independent Mitochondrial Activation in Tumor Necrosis Factor Alpha-Induced Apoptosis and Liver Injury. Mol. Cell. Biol.
27: 541-553
[Abstract]
[Full Text]
-
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(2007). Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells. Molecular Cancer Therapeutics
6: 82-92
[Abstract]
[Full Text]
-
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(2007). Dual effect of thapsigargin on cell death in porcine aortic smooth muscle cells. Am. J. Physiol. Cell Physiol.
292: C383-C395
[Abstract]
[Full Text]
-
Ho, J., Moir, S., Malaspina, A., Howell, M. L., Wang, W., DiPoto, A. C., O'Shea, M. A., Roby, G. A., Kwan, R., Mican, J. M., Chun, T.-W., Fauci, A. S.
(2006). Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanisms. Proc. Natl. Acad. Sci. USA
103: 19436-19441
[Abstract]
[Full Text]
-
Oh, K. J., Barbuto, S., Pitter, K., Morash, J., Walensky, L. D., Korsmeyer, S. J.
(2006). A Membrane-targeted BID BCL-2 Homology 3 Peptide Is Sufficient for High Potency Activation of BAX in Vitro. J. Biol. Chem.
281: 36999-37008
[Abstract]
[Full Text]
-
Gueorguieva, D., Li, S., Walsh, N., Mukerji, A., Tanha, J., Pandey, S.
(2006). Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis. FASEB J.
20: 2636-2638
[Abstract]
[Full Text]
-
Peng, J., Tan, C., Roberts, G. J., Nikolaeva, O., Zhang, Z., Lapolla, S. M., Primorac, S., Andrews, D. W., Lin, J.
(2006). tBid Elicits a Conformational Alteration in Membrane-bound Bcl-2 Such That It Inhibits Bax Pore Formation. J. Biol. Chem.
281: 35802-35811
[Abstract]
[Full Text]
-
Shulga, N., Pastorino, J. G.
(2006). Acyl Coenzyme A-binding Protein Augments Bid-induced Mitochondrial Damage and Cell Death by Activating {micro}-Calpain. J. Biol. Chem.
281: 30824-30833
[Abstract]
[Full Text]
-
Parone, P. A., James, D. I., Da Cruz, S., Mattenberger, Y., Donze, O., Barja, F., Martinou, J.-C.
(2006). Inhibiting the mitochondrial fission machinery does not prevent bax/bak-dependent apoptosis.. Mol. Cell. Biol.
26: 7397-7408
[Abstract]
[Full Text]
-
Palacios, C., Yerbes, R., Lopez-Rivas, A.
(2006). Flavopiridol Induces Cellular FLICE-Inhibitory Protein Degradation by the Proteasome and Promotes TRAIL-Induced Early Signaling and Apoptosis in Breast Tumor Cells.. Cancer Res.
66: 8858-8869
[Abstract]
[Full Text]
-
Kojima, K., Konopleva, M., McQueen, T., O'Brien, S., Plunkett, W., Andreeff, M.
(2006). Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood
108: 993-1000
[Abstract]
[Full Text]
-
Kim, B.-J., Ryu, S.-W., Song, B.-J.
(2006). JNK- and p38 Kinase-mediated Phosphorylation of Bax Leads to Its Activation and Mitochondrial Translocation and to Apoptosis of Human Hepatoma HepG2 Cells. J. Biol. Chem.
281: 21256-21265
[Abstract]
[Full Text]
-
Shrivastava, A., Tiwari, M., Sinha, R. A., Kumar, A., Balapure, A. K., Bajpai, V. K., Sharma, R., Mitra, K., Tandon, A., Godbole, M. M.
(2006). Molecular Iodine Induces Caspase-independent Apoptosis in Human Breast Carcinoma Cells Involving the Mitochondria-mediated Pathway. J. Biol. Chem.
281: 19762-19771
[Abstract]
[Full Text]
-
Tan, C., Dlugosz, P. J., Peng, J., Zhang, Z., Lapolla, S. M., Plafker, S. M., Andrews, D. W., Lin, J.
(2006). Auto-activation of the Apoptosis Protein Bax Increases Mitochondrial Membrane Permeability and Is Inhibited by Bcl-2. J. Biol. Chem.
281: 14764-14775
[Abstract]
[Full Text]
-
Zhang, Y., Gu, J., Zhao, L., He, L., Qian, W., Wang, J., Wang, Y., Qian, Q., Qian, C., Wu, J., Liu, X. Y.
(2006). Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy.. Cancer Res.
66: 4291-4298
[Abstract]
[Full Text]
-
Han, J., Goldstein, L. A., Gastman, B. R., Rabinowich, H.
(2006). Interrelated Roles for Mcl-1 and BIM in Regulation of TRAIL-mediated Mitochondrial Apoptosis. J. Biol. Chem.
281: 10153-10163
[Abstract]
[Full Text]
-
Jomary, C., Cullen, J., Jones, S. E.
(2006). Inactivation of the Akt Survival Pathway during Photoreceptor Apoptosis in the Retinal Degeneration Mouse.. IOVS
47: 1620-1629
[Abstract]
[Full Text]
-
Choi, S.-Y., Kim, M.-J., Kang, C.-M., Bae, S., Cho, C.-K., Soh, J.-W., Kim, J.-H., Kang, S., Chung, H. Y., Lee, Y.-S., Lee, S.-J.
(2006). Activation of Bak and Bax through c-Abl-Protein Kinase C{delta}-p38 MAPK Signaling in Response to Ionizing Radiation in Human Non-small Cell Lung Cancer Cells. J. Biol. Chem.
281: 7049-7059
[Abstract]
[Full Text]
-
Clohessy, J. G., Zhuang, J., de Boer, J., Gil-Gomez, G., Brady, H. J. M.
(2006). Mcl-1 Interacts with Truncated Bid and Inhibits Its Induction of Cytochrome c Release and Its Role in Receptor-mediated Apoptosis. J. Biol. Chem.
281: 5750-5759
[Abstract]
[Full Text]
-
Cudrici, C., Niculescu, F., Jensen, T., Zafranskaia, E., Fosbrink, M., Rus, V., Shin, M. L., Rus, H.
(2006). C5b-9 Terminal Complex Protects Oligodendrocytes from Apoptotic Cell Death by Inhibiting Caspase-8 Processing and Up-Regulating FLIP.. J. Immunol.
176: 3173-3180
[Abstract]
[Full Text]
-
Okumura, A. J., Hatsuzawa, K., Tamura, T., Nagaya, H., Saeki, K., Okumura, F., Nagao, K., Nishikawa, M., Yoshimura, A., Wada, I.
(2006). Involvement of a Novel Q-SNARE, D12, in Quality Control of the Endomembrane System. J. Biol. Chem.
281: 4495-4506
[Abstract]
[Full Text]
-
Su, J., Wang, G., Barrett, J. W., Irvine, T. S., Gao, X., McFadden, G.
(2006). Myxoma Virus M11L Blocks Apoptosis through Inhibition of Conformational Activation of Bax at the Mitochondria. J. Virol.
80: 1140-1151
[Abstract]
[Full Text]
-
Tikhomirov, O., Carpenter, G.
(2005). Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J. Cell Sci.
118: 5681-5690
[Abstract]
[Full Text]
-
Pagliari, L. J., Kuwana, T., Bonzon, C., Newmeyer, D. D., Tu, S., Beere, H. M., Green, D. R.
(2005). The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc. Natl. Acad. Sci. USA
102: 17975-17980
[Abstract]
[Full Text]
-
Essmann, F., Pohlmann, S., Gillissen, B., Daniel, P. T., Schulze-Osthoff, K., Janicke, R. U.
(2005). Irradiation-induced Translocation of p53 to Mitochondria in the Absence of Apoptosis. J. Biol. Chem.
280: 37169-37177
[Abstract]
[Full Text]
-
Tan, K. O., Fu, N. Y., Sukumaran, S. K., Chan, S.-L., Kang, J. H., Poon, K. L., Chen, B. S., Yu, V. C.
(2005). MAP-1 is a mitochondrial effector of Bax. Proc. Natl. Acad. Sci. USA
102: 14623-14628
[Abstract]
[Full Text]
-
Redlak, M. J., Power, J. J., Miller, T. A.
(2005). Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol.
289: G731-G738
[Abstract]
[Full Text]
-
Seth, R., Yang, C., Kaushal, V., Shah, S. V., Kaushal, G. P.
(2005). p53-dependent Caspase-2 Activation in Mitochondrial Release of Apoptosis-inducing Factor and Its Role in Renal Tubular Epithelial Cell Injury. J. Biol. Chem.
280: 31230-31239
[Abstract]
[Full Text]
-
Neuspiel, M., Zunino, R., Gangaraju, S., Rippstein, P., McBride, H.
(2005). Activated Mitofusin 2 Signals Mitochondrial Fusion, Interferes with Bax Activation, and Reduces Susceptibility to Radical Induced Depolarization. J. Biol. Chem.
280: 25060-25070
[Abstract]
[Full Text]
-
Lin, C.-F., Chen, C.-L., Chang, W.-T., Jan, M.-S., Hsu, L.-J., Wu, R.-H., Fang, Y.-T., Tang, M.-J., Chang, W.-C., Lin, Y.-S.
(2005). Bcl-2 Rescues Ceramide- and Etoposide-induced Mitochondrial Apoptosis through Blockage of Caspase-2 Activation. J. Biol. Chem.
280: 23758-23765
[Abstract]
[Full Text]
-
Mathai, J. P., Germain, M., Shore, G. C.
(2005). BH3-only BIK Regulates BAX,BAK-dependent Release of Ca2+ from Endoplasmic Reticulum Stores and Mitochondrial Apoptosis during Stress-induced Cell Death. J. Biol. Chem.
280: 23829-23836
[Abstract]
[Full Text]
-
Grinberg, M., Schwarz, M., Zaltsman, Y., Eini, T., Niv, H., Pietrokovski, S., Gross, A.
(2005). Mitochondrial Carrier Homolog 2 Is a Target of tBID in Cells Signaled To Die by Tumor Necrosis Factor Alpha. Mol. Cell. Biol.
25: 4579-4590
[Abstract]
[Full Text]
-
Kashkar, H., Wiegmann, K., Yazdanpanah, B., Haubert, D., Kronke, M.
(2005). Acid Sphingomyelinase Is Indispensable for UV Light-induced Bax Conformational Change at the Mitochondrial Membrane. J. Biol. Chem.
280: 20804-20813
[Abstract]
[Full Text]
-
Hurbin, A., Coll, J.-L., Dubrez-Daloz, L., Mari, B., Auberger, P., Brambilla, C., Favrot, M.-C.
(2005). Cooperation of Amphiregulin and Insulin-like Growth Factor-1 Inhibits Bax- and Bad-mediated Apoptosis via a Protein Kinase C-dependent Pathway in Non-small Cell Lung Cancer Cells. J. Biol. Chem.
280: 19757-19767
[Abstract]
[Full Text]
-
Milhas, D., Cuvillier, O., Therville, N., Clave, P., Thomsen, M., Levade, T., Benoist, H., Segui, B.
(2005). Caspase-10 Triggers Bid Cleavage and Caspase Cascade Activation in FasL-induced Apoptosis. J. Biol. Chem.
280: 19836-19842
[Abstract]
[Full Text]
-
Nhan, T. Q., Liles, W. C., Schwartz, S. M.
(2005). Role of Caspases in Death and Survival of the Plaque Macrophage. Arterioscler. Thromb. Vasc. Bio.
25: 895-903
[Abstract]
[Full Text]
-
Dejean, L. M., Martinez-Caballero, S., Guo, L., Hughes, C., Teijido, O., Ducret, T., Ichas, F., Korsmeyer, S. J., Antonsson, B., Jonas, E. A., Kinnally, K. W.
(2005). Oligomeric Bax Is a Component of the Putative Cytochrome c Release Channel MAC, Mitochondrial Apoptosis-induced Channel. Mol. Biol. Cell
16: 2424-2432
[Abstract]
[Full Text]
-
Luciano, F., Zhai, D., Zhu, X., Bailly-Maitre, B., Ricci, J.-E., Satterthwait, A. C., Reed, J. C.
(2005). Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL. J. Biol. Chem.
280: 15825-15835
[Abstract]
[Full Text]
-
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(2005). Variable expression of protein kinase C{varepsilon} in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis. Molecular Cancer Therapeutics
4: 668-676
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-
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(2005). Bid Mediates Apoptotic Synergy between Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and DNA Damage. J. Biol. Chem.
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[Full Text]
-
Weng, C., Li, Y., Xu, D., Shi, Y., Tang, H.
(2005). Specific Cleavage of Mcl-1 by Caspase-3 in Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis in Jurkat Leukemia T Cells. J. Biol. Chem.
280: 10491-10500
[Abstract]
[Full Text]
-
Cartron, P.-F., Arokium, H., Oliver, L., Meflah, K., Manon, S., Vallette, F. M.
(2005). Distinct Domains Control the Addressing and the Insertion of Bax into Mitochondria. J. Biol. Chem.
280: 10587-10598
[Abstract]
[Full Text]
-
Klee, M., Pimentel-Muinos, F. X.
(2005). Bcl-XL specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum. JCB
168: 723-734
[Abstract]
[Full Text]
-
Desagher, S., Severac, D., Lipkin, A., Bernis, C., Ritchie, W., Le Digarcher, A., Journot, L.
(2005). Genes Regulated in Neurons Undergoing Transcription-dependent Apoptosis Belong to Signaling Pathways Rather than the Apoptotic Machinery. J. Biol. Chem.
280: 5693-5702
[Abstract]
[Full Text]
-
Lucken-Ardjomande, S., Martinou, J.-C.
(2005). Newcomers in the process of mitochondrial permeabilization. J. Cell Sci.
118: 473-483
[Abstract]
[Full Text]
-
Kaushal, G. P., Liu, L., Kaushal, V., Hong, X., Melnyk, O., Seth, R., Safirstein, R., Shah, S. V.
(2004). Regulation of caspase-3 and -9 activation in oxidant stress to RTE by forkhead transcription factors, Bcl-2 proteins, and MAP kinases. Am. J. Physiol. Renal Physiol.
287: F1258-F1268
[Abstract]
[Full Text]
-
Guihard, G., Bellot, G., Moreau, C., Pradal, G., Ferry, N., Thomy, R., Fichet, P., Meflah, K., Vallette, F. M.
(2004). The Mitochondrial Apoptosis-induced Channel (MAC) Corresponds to a Late Apoptotic Event. J. Biol. Chem.
279: 46542-46550
[Abstract]
[Full Text]
-
Ahmad, K. A., Iskandar, K. B., Hirpara, J. L., Clement, M.-V., Pervaiz, S.
(2004). Hydrogen Peroxide-Mediated Cytosolic Acidification Is a Signal for Mitochondrial Translocation of Bax during Drug-Induced Apoptosis of Tumor Cells. Cancer Res.
64: 7867-7878
[Abstract]
[Full Text]
-
Lee, Y.-j., Jeong, S.-Y., Karbowski, M., Smith, C. L., Youle, R. J.
(2004). Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis. Mol. Biol. Cell
15: 5001-5011
[Abstract]
[Full Text]
-
Andoniou, C. E., Andrews, D. M., Manzur, M., Ricciardi-Castagnoli, P., Degli-Esposti, M. A.
(2004). A novel checkpoint in the Bcl-2-regulated apoptotic pathway revealed by murine cytomegalovirus infection of dendritic cells. JCB
166: 827-837
[Abstract]
[Full Text]
-
De Marchi, U., Campello, S., Szabo, I., Tombola, F., Martinou, J.-C., Zoratti, M.
(2004). Bax Does Not Directly Participate in the Ca2+-induced Permeability Transition of Isolated Mitochondria. J. Biol. Chem.
279: 37415-37422
[Abstract]
[Full Text]
-
Zhang, L., Shimizu, S., Sakamaki, K., Yonehara, S., Tsujimoto, Y.
(2004). A Caspase-8-independent Signaling Pathway Activated by Fas Ligation Leads to Exposure of the Bak N Terminus. J. Biol. Chem.
279: 33865-33874
[Abstract]
[Full Text]
-
Valentijn, A. J., Gilmore, A. P.
(2004). Translocation of Full-length Bid to Mitochondria during Anoikis. J. Biol. Chem.
279: 32848-32857
[Abstract]
[Full Text]
-
Terrones, O., Antonsson, B., Yamaguchi, H., Wang, H.-G., Liu, J., Lee, R. M., Herrmann, A., Basanez, G.
(2004). Lipidic Pore Formation by the Concerted Action of Proapoptotic BAX and tBID. J. Biol. Chem.
279: 30081-30091
[Abstract]
[Full Text]
-
Reed, J. C., Doctor, K. S., Godzik, A.
(2004). The Domains of Apoptosis: A Genomics Perspective. Sci Signal
2004: re9-re9
[Abstract]
[Full Text]
-
Beere, H. M.
(2004). `The stress of dying': the role of heat shock proteins in the regulation of apoptosis. J. Cell Sci.
117: 2641-2651
[Abstract]
[Full Text]
-
Maianski, N. A., Roos, D., Kuijpers, T. W.
(2004). Bid Truncation, Bid/Bax Targeting to the Mitochondria, and Caspase Activation Associated with Neutrophil Apoptosis Are Inhibited by Granulocyte Colony-Stimulating Factor. J. Immunol.
172: 7024-7030
[Abstract]
[Full Text]
-
Arnoult, D., Bartle, L. M., Skaletskaya, A., Poncet, D., Zamzami, N., Park, P. U., Sharpe, J., Youle, R. J., Goldmacher, V. S.
(2004). Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc. Natl. Acad. Sci. USA
101: 7988-7993
[Abstract]
[Full Text]
-
Gustafsson, A. B., Tsai, J. G., Logue, S. E., Crow, M. T., Gottlieb, R. A.
(2004). Apoptosis Repressor with Caspase Recruitment Domain Protects against Cell Death by Interfering with Bax Activation. J. Biol. Chem.
279: 21233-21238
[Abstract]
[Full Text]