Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis

doi:10.1083/jcb.145.3.579

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J. Cell Biol., Volume 145, Number 3, May 3, 1999 579-588

Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis

Kazumasa Morita,^* Hiroyuki Sasaki,^¶ Kazushi Fujimoto,^§ Mikio Furuse,^* and Shoichiro Tsukita^*

^* Department of Cell Biology, Department of Dermatology, and ^§ Department of Anatomy, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, Japan; Laboratory of Cell Biology, KAN Research Institute Inc., Minami-Kaneda, Suita, Osaka 564, Japan; and ^¶ Department of Molecular Cell Biology, Institute of DNA Medicine, Jikei University School of Medicine, Nishi-Shinbashi, Minato-ku, Tokyo 105, Japan

Members of the newly identified claudin gene family constitute tight junction (TJ) strands, which play a pivotal role in compartmentalizationin multicellular organisms. We identified oligodendrocyte-specificprotein (OSP) as claudin-11, a new claudin family member, dueto its sequence similarity to claudins as well as its abilityto form TJ strands in transfected fibroblasts. Claudin-11/OSPmRNA was expressed in the brain and testis. Immunofluorescencemicroscopy with anti-claudin-11/OSP polyclonal antibody (pAb)and anti-neurofilament mAb revealed that in the brain claudin-11/OSP-positivelinear structures run in a gentle spiral around neurofilament-positiveaxons. At the electron microscopic level, these linear structureswere identified as the so-called interlamellar strands in myelinsheaths of oligodendrocytes. In testis, well-developed TJ strandsof Sertoli cells were specifically labeled with anti-claudin-11/OSPpAb both at immunofluorescence and electron microscopic levels.These findings indicated that the interlamellar strands of oligodendrocytemyelin sheaths can be regarded as a variant of TJ strands foundin many other epithelial cells, and that these strands share aspecific claudin species, claudin-11/OSP, with those in Sertolicells to create and maintain the repeated compartments aroundaxons byoligodendrocytes.

Key words: oligodendrocyte; myelin sheath; tight junction; Sertoli cell; claudin-11; oligodendrocyte-specific protein

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