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J. Cell Biol.,
Volume 145, Number 5, May 31, 1999 1063-1076
Laboratoire de Génétique et Physiologie du Développement, UMR 6545 CNRS-Université, IBDM
CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
The gene encoding the In the nervous system, the expression of Go Mutants produced in the Go
subunit of the
Drosophila Go protein is expressed early in embryogenesis in the precursor cells of the heart tube, of the
visceral muscles, and of the nervous system. This
early expression coincides with the onset of the mesenchymal-epithelial transition to which are subjected
the cardial cells and the precursor cells of the visceral
musculature. This gene constitutes an appropriate marker to follow this transition. In addition, a detailed analysis of its expression suggests that the cardioblasts originate from two subpopulations of cells in
each parasegment of the dorsal mesoderm that might
depend on the wingless and hedgehog signaling pathways for both their determination and specification.
shortly precedes the beginning of axonogenesis.
gene harbor abnormalities in the three tissues in which the gene is expressed. In particular, the heart does not form properly and interruptions in the heart epithelium are
repeatedly observed, henceforth the brokenheart (bkh)
name. Furthermore, in the bkh mutant embryos, the
epithelial polarity of cardial cells was not acquired
(or maintained) in various places of the cardiac tube.
We predict that bkh might be involved in vesicular
traffic of membrane proteins that is responsible for
the acquisition of polarity.
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