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J. Cell Biol.,
Volume 145, Number 6, June 14, 1999 1165-1175
* Department of Biochemistry and Molecular Biophysics, Mutations in the Caenorhabditis elegans
sel-9 gene elevate the activity of lin-12 and glp-1, which
encode members of the LIN-12/NOTCH family of receptors. Sequence analysis indicates SEL-9 is one of
several C. elegans p24 proteins. Allele-specific genetic
interactions suggest that reducing sel-9 activity increases the activity of mutations altering the extracellular domains of LIN-12 or GLP-1. Reducing sel-9 activity restores the trafficking to the plasma membrane of a
mutant GLP-1 protein that would otherwise accumulate within the cell. Our results suggest a role for SEL-9
and other p24 proteins in the negative regulation of
transport of LIN-12 and GLP-1 to the cell surface, and
favor a role for p24 proteins in a quality control mechanism for endoplasmic reticulum-Golgi transport.
Howard Hughes Medical Institute, Columbia University, College of
Physicians and Surgeons, New York, New York 10032
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