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© The Rockefeller University Press, 0021-9525/1999//731 $5.00
The Journal of Cell Biology, Volume 146, Number 4, , 1999 731-740

Original Article

The Developmental Role of warthog, the Notch Modifier Encoding Drab6



Karen Purcella and Spyros Artavanis-Tsakonasa

a Department of Cell Biology, Yale University, New Haven, Connecticut 06510
Massachusetts General Hospital Cancer Center and the Department of Cell Biology, Harvard Medical School, 13th Street, Charlestown, MA 02129-2000.(617) 726-6857(617) 726-6863

tsakonas{at}helix.mgh.harvard.edu

The warthog (wrt) gene, recovered as a modifier for Notch signaling, was found to encode the Drosophila homologue of rab6, Drab6. Vertebrate and yeast homologues of this protein have been shown to regulate Golgi network to TGN trafficking. To study the function of this protein in the development of a multicellular organism, we analyzed three different warthog mutants. The first was an R62C point mutation, the second a genomic null, and the third was an engineered GTP-bound form. Our studies show, contrary to yeast, that the Drosophila homologue of rab6 is an essential gene. However, it has limited effects on development beyond the larval stage. Only the mechanosensory bristles on the head, notum, and scutellum are affected by warthog mutations. We present models for the modifying effect of Drab6 on Notch signaling.

Key Words: Drosophila • Drab6 • warthog • bristle • Golgi network

© 1999 The Rockefeller University Press

1.used in this paper: ORF, open reading frame; wrt, warthog


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