JCB logo
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 220K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fan, H.
Right arrow Articles by Khavari, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fan, H.
Right arrow Articles by Khavari, P. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

© The Rockefeller University Press, 0021-9525/1999//71 $5.00
The Journal of Cell Biology, Volume 147, Number 1, , 1999 71-76

Original Article

Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest



Hongran Fana,b and Paul A. Khavaria,c

a VA Palo Alto Health Care System, Palo Alto, California 94304
b Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305
c Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305
Stanford University School of Medicine, P204, MSLS Building, Stanford, CA 94305.(650) 723-8762(650) 725-5266

khavari{at}cmgm.stanford.edu

Stratified epithelium displays an equilibrium between proliferation and cell cycle arrest, a balance that is disrupted in basal cell carcinoma (BCC). Sonic hedgehog (Shh) pathway activation appears sufficient to induce BCC, however, the way it does so is unknown. Shh-induced epidermal hyperplasia is accompanied by continued cell proliferation in normally growth arrested suprabasal cells in vivo. Shh-expressing cells fail to exit S and G2/M phases in response to calcium-induced differentiation and also resist exhaustion of replicative growth capacity. In addition, Shh blocks p21CIP1/WAF1-induced growth arrest. These data indicate that Shh promotes neoplasia by opposing normal stimuli for epithelial cell cycle arrest.

Key Words: Sonic hedgehog • epidermis • cell cycle regulation • basal cell carcinoma • cyclin-dependent kinase inhibitor

© 1999 The Rockefeller University Press

1.used in this paper: Shh, Sonic hedgehog; BCC, basal cell carcinoma; BrdU, bromodeoxyuridine; CDK, cyclin-dependent kinase; CKI, cyclin dependent kinase inhibitor; SA-β-gal, senescence-associated β-galactosidase


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents