Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape

doi:10.1083/jcb.147.4.699

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© The Rockefeller University Press, 0021-9525/1999//699 $5.00
The Journal of Cell Biology, Volume 147, Number 4, , 1999 699-706

Brief Report

Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape

Hiromi Sesaki^a and Robert E. Jensen^a

^a Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205.(410) 955-4129(410) 955-7291

rjensen{at}jhmi.edu

In yeast, mitochondrial division and fusion are highly regulatedduring growth, mating and sporulation, yet the mechanisms controllingthese activities are unknown. Using a novel screen, we isolatedmutants in which mitochondria lose their normal structure, andinstead form a large network of interconnected tubules. Thesemutants, which appear defective in mitochondrial division, allcarried mutations in DNM1, a dynamin-related protein that localizesto mitochondria. We also isolated mutants containing numerousmitochondrial fragments. These mutants were defective in FZO1,a gene previously shown to be required for mitochondrial fusion.Surprisingly, we found that in dnm1 fzo1 double mutants, normalmitochondrial shape is restored. Induction of Dnm1p expressionin dnm1 fzo1 cells caused rapid fragmentation of mitochondria.We propose that dnm1 mutants are defective in the mitochondrialdivision, an activity antagonistic to fusion. Our results thussuggest that mitochondrial shape is normally controlled by abalance between division and fusion which requires Dnm1p andFzo1p, respectively.

Key Words: mitochondrial division • mitochondrial fusion • dynamin • GTPase • yeast

Abbreviations used in this paper: GFP, green fluorescent protein;mtDNA, mitochondrial DNA.

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