Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites

doi:10.1083/jcb.147.5.937

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© The Rockefeller University Press, 0021-9525/1999/11/937/ $5.00
The Journal of Cell Biology, Volume 147, Number 5, November 29, 1999 937-944

Brief Report

Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites

Stefan Kappe^a, Thomas Bruderer^a, Soren Gantt^a, Hisashi Fujioka^c, Victor Nussenzweig^a, and Robert Ménard^a,b
^a Department of Pathology, Kaplan Cancer Center
^b Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10016
^c Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

Correspondence to: Robert Ménard, Department of Pathology, Division of Immunology, New York University School of Medicine, 550 First Avenue, New York, NY 10016. Tel:(212) 263-7870 Fax:(212) 263-8179 E-mail:menarr01{at}mcrcr6.med.nyu.edu.

Most Apicomplexan parasites, including the human pathogens Plasmodium,Toxoplasma, and Cryptosporidium, actively invade host cellsand display gliding motility, both actions powered by parasitemicrofilaments. In Plasmodium sporozoites, thrombospondin-relatedanonymous protein (TRAP), a member of a group of Apicomplexantransmembrane proteins that have common adhesion domains, isnecessary for gliding motility and infection of the vertebratehost. Here, we provide genetic evidence that TRAP is directlyinvolved in a capping process that drives both sporozoite glidingand cell invasion. We also demonstrate that TRAP-related proteinsin other Apicomplexa fulfill the same function and that theircytoplasmic tails interact with homologous partners in the respectiveparasite. Therefore, a mechanism of surface redistribution ofTRAP-related proteins driving gliding locomotion and cell invasionis conserved among Apicomplexan parasites.

Key Words: gliding motility, cell invasion, Apicomplexan parasites, thrombospondin-relatedanonymous protein, micronemal protein 2

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