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© The Rockefeller University Press, 0021-9525/1999//1371 $5.00
The Journal of Cell Biology, Volume 147, Number 7, , 1999 1371-1378

Brief Report

Mitotic Regulators Govern Progress through Steps in the Centrosome Duplication Cycle



Smruti J. Vidwansa, Mei Lie Wonga, and Patrick H. O'Farrella

a Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California 94143-0448
Box 0448, 513 Parnassus Avenue, University of California-San Francisco, San Francisco, CA 94143-0448.(415) 502-5145(415) 476-4707

ofarrell{at}cgl.ucsf.edu

Centrosome duplication is marked by discrete changes in centriole structure that occur in lockstep with cell cycle transitions. We show that mitotic regulators govern steps in centriole replication in Drosophila embryos. Cdc25string, the expression of which initiates mitosis, is required for completion of daughter centriole assembly. Cdc20fizzy, which is required for the metaphase-anaphase transition, is required for timely disengagement of mother and daughter centrioles. Stabilization of mitotic cyclins, which prevents exit from mitosis, blocks assembly of new daughter centrioles. Common regulation of the nuclear and centrosome cycles by mitotic regulators may ensure precise duplication of the centrosome.

Key Words: centrosome • duplication • cell cycle • coupling • Drosophila

© 1999 The Rockefeller University Press

Abbreviations used in this paper: APC, ANAPHASE promoting complex; Cdk, cyclin-dependent kinase; VE, ventral epidermis.


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