The Elusive Functions of Proteoglycans: In Vivo Veritas

doi:10.1083/jcb.148.2.227

This Article

Full Text

Full Text (PDF, 67K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JCB

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Lander, A. D.

Articles by Selleck, S. B.

Search for Related Content

PubMed

PubMed Citation

Articles by Lander, A. D.

Articles by Selleck, S. B.

Pubmed/NCBI databases

Gene	GEO Profiles
HomoloGene	UniGene
Substance via MeSH

Social Bookmarking

What's this?

© The Rockefeller University Press, 0021-9525/2000/1/227/ $5.00
The Journal of Cell Biology, Volume 148, Number 2, January 24, 2000 227-232

Mini-Review

The Elusive Functions of Proteoglycans: In Vivo Veritas

Arthur D. Lander^a and Scott B. Selleck^b
^a Department of Developmental and Cell Biology, University of California, Irvine, California 92697
^b Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721

Correspondence to: Arthur D. Lander, Department of Developmental and Cell Biology, University of California, CA 92697-2275. Tel:(949) 824-1008 Fax:(949) 824-1083 E-mail:adlander{at}uci.edu.

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Tone, Y., Pedersen, L. C., Yamamoto, T., Izumikawa, T., Kitagawa, H., Nishihara, J., Tamura, J.-i., Negishi, M., Sugahara, K. (2008). 2-O-Phosphorylation of Xylose and 6-O-Sulfation of Galactose in the Protein Linkage Region of Glycosaminoglycans Influence the Glucuronyltransferase-I Activity Involved in the Linkage Region Synthesis. J. Biol. Chem. 283: 16801-16807 [Abstract] [Full Text]
Paris, S., Burlacu, A., Durocher, Y. (2008). Opposing Roles of Syndecan-1 and Syndecan-2 in Polyethyleneimine-mediated Gene Delivery. J. Biol. Chem. 283: 7697-7704 [Abstract] [Full Text]
Johnson, C. E., Crawford, B. E., Stavridis, M., ten Dam, G., Wat, A. L., Rushton, G., Ward, C. M., Wilson, V., van Kuppevelt, T. H., Esko, J. D., Smith, A., Gallagher, J. T., Merry, C. L. R. (2007). Essential Alterations of Heparan Sulfate During the Differentiation of Embryonic Stem Cells to Sox1-Enhanced Green Fluorescent Protein-Expressing Neural Progenitor Cells. Stem Cells 25: 1913-1923 [Abstract] [Full Text]
Deepa, S. S, Yamada, S., Fukui, S., Sugahara, K. (2007). Structural determination of novel sulfated octasaccharides isolated from chondroitin sulfate of shark cartilage and their application for characterizing monoclonal antibody epitopes. Glycobiology 17: 631-645 [Abstract] [Full Text]
Bown, L., Kusaba, S., Goubet, F., Codrai, L., Dale, A. G., Zhang, Z., Yu, X., Morris, K., Ishii, T., Evered, C., Dupree, P., Jackson, S. (2007). The ectopically parting cells 1-2 (epc1-2) mutant exhibits an exaggerated response to abscisic acid. J Exp Bot 58: 1813-1823 [Abstract] [Full Text]
Matsumoto, Y., Irie, F., Inatani, M., Tessier-Lavigne, M., Yamaguchi, Y. (2007). Netrin-1/DCC Signaling in Commissural Axon Guidance Requires Cell-Autonomous Expression of Heparan Sulfate. J. Neurosci. 27: 4342-4350 [Abstract] [Full Text]
Zernichow, L., Abrink, M., Hallgren, J., Grujic, M., Pejler, G., Kolset, S. O. (2006). Serglycin Is the Major Secreted Proteoglycan in Macrophages and Has a Role in the Regulation of Macrophage Tumor Necrosis Factor-{alpha} Secretion in Response to Lipopolysaccharide. J. Biol. Chem. 281: 26792-26801 [Abstract] [Full Text]
Comelli, E. M., Head, S. R., Gilmartin, T., Whisenant, T., Haslam, S. M., North, S. J., Wong, N.-K., Kudo, T., Narimatsu, H., Esko, J. D., Drickamer, K., Dell, A., Paulson, J. C. (2006). A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology 16: 117-131 [Abstract] [Full Text]
Izumikawa, T., Egusa, N., Taniguchi, F., Sugahara, K., Kitagawa, H. (2006). Heparan Sulfate Polymerization in Drosophila. J. Biol. Chem. 281: 1929-1934 [Abstract] [Full Text]
Ding, K., Lopez-Burks, M., Sanchez-Duran, J. A., Korc, M., Lander, A. D. (2005). Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. JCB 171: 729-738 [Abstract] [Full Text]
Wei, Z., Lyon, M., Gallagher, J. T. (2005). Distinct Substrate Specificities of Bacterial Heparinases against N-Unsubstituted Glucosamine Residues in Heparan Sulfate. J. Biol. Chem. 280: 15742-15748 [Abstract] [Full Text]
Pankonin, M. S., Gallagher, J. T., Loeb, J. A. (2005). Specific Structural Features of Heparan Sulfate Proteoglycans Potentiate Neuregulin-1 Signaling. J. Biol. Chem. 280: 383-388 [Abstract] [Full Text]
Abrink, M., Grujic, M., Pejler, G. (2004). Serglycin Is Essential for Maturation of Mast Cell Secretory Granule. J. Biol. Chem. 279: 40897-40905 [Abstract] [Full Text]
Armstrong, E. J., Bischoff, J. (2004). Heart Valve Development: Endothelial Cell Signaling and Differentiation. Circ. Res. 95: 459-470 [Abstract] [Full Text]
Shute, J K, Solic, N, Shimizu, J, McConnell, W, Redington, A E, Howarth, P H (2004). Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma. Thorax 59: 557-562 [Abstract] [Full Text]
Murphy, K. J., Merry, C. L. R., Lyon, M., Thompson, J. E., Roberts, I. S., Gallagher, J. T. (2004). A New Model for the Domain Structure of Heparan Sulfate Based on the Novel Specificity of K5 Lyase. J. Biol. Chem. 279: 27239-27245 [Abstract] [Full Text]
Bornemann, D. J., Duncan, J. E., Staatz, W., Selleck, S., Warrior, R. (2004). Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways. Development 131: 1927-1938 [Abstract] [Full Text]
Takeo, S., Fujise, M., Akiyama, T., Habuchi, H., Itano, N., Matsuo, T., Aigaki, T., Kimata, K., Nakato, H. (2004). In Vivo Hyaluronan Synthesis upon Expression of the Mammalian Hyaluronan Synthase Gene in Drosophila. J. Biol. Chem. 279: 18920-18925 [Abstract] [Full Text]
Powell, A. K., Yates, E. A., Fernig, D. G., Turnbull, J. E. (2004). Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and experimental approaches. Glycobiology 14: 17R-30R [Abstract] [Full Text]
Han, C., Belenkaya, T. Y., Khodoun, M., Tauchi, M., Lin, X., Lin, X. (2004). Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development 131: 1563-1575 [Abstract] [Full Text]
Cheon, Y.-P., Xu, X., Bagchi, M. K., Bagchi, I. C. (2003). Immune-Responsive Gene 1 Is a Novel Target of Progesterone Receptor and Plays a Critical Role during Implantation in the Mouse. Endocrinology 144: 5623-5630 [Abstract] [Full Text]
De Cat, B., Muyldermans, S.-Y., Coomans, C., Degeest, G., Vanderschueren, B., Creemers, J., Biemar, F., Peers, B., David, G. (2003). Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. JCB 163: 625-635 [Abstract] [Full Text]
Kim, B.-T., Kitagawa, H., Tanaka, J., Tamura, J.-i., Sugahara, K. (2003). In Vitro Heparan Sulfate Polymerization: CRUCIAL ROLES OF CORE PROTEIN MOIETIES OF PRIMER SUBSTRATES IN ADDITION TO THE EXT1-EXT2 INTERACTION. J. Biol. Chem. 278: 41618-41623 [Abstract] [Full Text]
Maeda, N., He, J., Yajima, Y., Mikami, T., Sugahara, K., Yabe, T. (2003). Heterogeneity of the Chondroitin Sulfate Portion of Phosphacan/6B4 Proteoglycan Regulates Its Binding Affinity for Pleiotrophin/Heparin Binding Growth-associated Molecule. J. Biol. Chem. 278: 35805-35811 [Abstract] [Full Text]
Wu, Z. L., Zhang, L., Yabe, T., Kuberan, B., Beeler, D. L., Love, A., Rosenberg, R. D. (2003). The Involvement of Heparan Sulfate (HS) in FGF1/HS/FGFR1 Signaling Complex. J. Biol. Chem. 278: 17121-17129 [Abstract] [Full Text]
Morimoto-Tomita, M., Uchimura, K., Werb, Z., Hemmerich, S., Rosen, S. D. (2002). Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans. J. Biol. Chem. 277: 49175-49185 [Abstract] [Full Text]
Cheng, F., Mani, K., van den Born, J., Ding, K., Belting, M., Fransson, L.-A. (2002). Nitric Oxide-dependent Processing of Heparan Sulfate in Recycling S-Nitrosylated Glypican-1 Takes Place in Caveolin-1-containing Endosomes. J. Biol. Chem. 277: 44431-44439 [Abstract] [Full Text]
Ford-Perriss, M., Guimond, S. E., Greferath, U., Kita, M., Grobe, K., Habuchi, H., Kimata, K., Esko, J. D., Murphy, M., Turnbull, J. E. (2002). Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology 12: 721-727 [Abstract] [Full Text]
Martin, L. T., Marth, J. D., Varki, A., Varki, N. M. (2002). Genetically Altered Mice with Different Sialyltransferase Deficiencies Show Tissue-specific Alterations in Sialylation and Sialic Acid 9-O-Acetylation. J. Biol. Chem. 277: 32930-32938 [Abstract] [Full Text]
Ding, K., Mani, K., Cheng, F., Belting, M., Fransson, L.-A. (2002). Copper-dependent Autocleavage of Glypican-1 Heparan Sulfate by Nitric Oxide Derived from Intrinsic Nitrosothiols. J. Biol. Chem. 277: 33353-33360 [Abstract] [Full Text]
Engbring, J. A., Hoffman, M. P., Karmand, A. J., Kleinman, H. K. (2002). The B16F10 Cell Receptor for a Metastasis-promoting Site on Laminin-1 Is a Heparan Sulfate/Chondroitin Sulfate-containing Proteoglycan. Cancer Res. 62: 3549-3554 [Abstract] [Full Text]
Moriarity, J. L., Hurt, K. J., Resnick, A. C., Storm, P. B., Laroy, W., Schnaar, R. L., Snyder, S. H. (2002). UDP-glucuronate Decarboxylase, a Key Enzyme in Proteoglycan Synthesis. CLONING, CHARACTERIZATION, AND LOCALIZATION. J. Biol. Chem. 277: 16968-16975 [Abstract] [Full Text]
Borgquist, J. D., Quinn, M. T., Swain, S. D. (2002). Adhesion to extracellular matrix proteins modulates bovine neutrophil responses to inflammatory mediators. J. Leukoc. Biol. 71: 764-774 [Abstract] [Full Text]
Zhang, L., Beeler, D. L., Lawrence, R., Lech, M., Liu, J., Davis, J. C., Shriver, Z., Sasisekharan, R., Rosenberg, R. D. (2001). 6-O-Sulfotransferase-1 Represents a Critical Enzyme in the Anticoagulant Heparan Sulfate Biosynthetic Pathway. J. Biol. Chem. 276: 42311-42321 [Abstract] [Full Text]
Karihaloo, A., Karumanchi, S. A., Barasch, J., Jha, V., Nickel, C. H., Yang, J., Grisaru, S., Bush, K. T., Nigam, S., Rosenblum, N. D., Sukhatme, V. P., Cantley, L. G. (2001). Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proc. Natl. Acad. Sci. USA 10.1073/pnas.221205198v1 [Abstract] [Full Text]
Walsh, E. C., Stainier, D. Y. R. (2001). UDP-Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish. Science 293: 1670-1673 [Abstract] [Full Text]
Kim, B.-T., Kitagawa, H., Tamura, J.-i., Saito, T., Kusche-Gullberg, M., Lindahl, U., Sugahara, K. (2001). Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis. Proc. Natl. Acad. Sci. USA 10.1073/pnas.131188498v1 [Abstract] [Full Text]
Julian, J., Das, S. K., Dey, S. K., Baraniak, D., Ta, V.-T., Carson, D. D. (2001). Expression of Heparin/Heparan Sulfate Interacting Protein/Ribosomal Protein L29 During the Estrous Cycle and Early Pregnancy in the Mouse. Biol. Reprod. 64: 1165-1175 [Abstract] [Full Text]
Zimmermann, P., Tomatis, D., Rosas, M., Grootjans, J., Leenaerts, I., Degeest, G., Reekmans, G., Coomans, C., David, G. (2001). Characterization of Syntenin, a Syndecan-binding PDZ Protein, as a Component of Cell Adhesion Sites and Microfilaments. Mol. Biol. Cell 12: 339-350 [Abstract] [Full Text]
Baeg, G., Lin, X, Khare, N, Baumgartner, S, Perrimon, N (2001). Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development 128: 87-94 [Abstract]
Wei, G., Bai, X., Gabb, M. M. G., Bame, K. J., Koshy, T. I., Spear, P. G., Esko, J. D. (2000). Location of the Glucuronosyltransferase Domain in the Heparan Sulfate Copolymerase EXT1 by Analysis of Chinese Hamster Ovary Cell Mutants. J. Biol. Chem. 275: 27733-27740 [Abstract] [Full Text]
Santra, M., Eichstetter, I., Iozzo, R. V. (2000). An Anti-oncogenic Role for Decorin. DOWN-REGULATION OF ErbB2 LEADS TO GROWTH SUPPRESSION AND CYTODIFFERENTIATION OF MAMMARY CARCINOMA CELLS. J. Biol. Chem. 275: 35153-35161 [Abstract] [Full Text]
Mongiat, M., Otto, J., Oldershaw, R., Ferrer, F., Sato, J. D., Iozzo, R. V. (2001). Fibroblast Growth Factor-binding Protein Is a Novel Partner for Perlecan Protein Core. J. Biol. Chem. 276: 10263-10271 [Abstract] [Full Text]
Zhang, L., Lawrence, R., Schwartz, J. J., Bai, X., Wei, G., Esko, J. D., Rosenberg, R. D. (2001). The Effect of Precursor Structures on the Action of Glucosaminyl 3-O-Sulfotransferase-1 and the Biosynthesis of Anticoagulant Heparan Sulfate. J. Biol. Chem. 276: 28806-28813 [Abstract] [Full Text]
Belting, M., Borsig, L., Fuster, M. M., Brown, J. R., Persson, L., Fransson, L.-A., Esko, J. D. (2002). Tumor attenuation by combined heparan sulfate and polyamine depletion. Proc. Natl. Acad. Sci. USA 99: 371-376 [Abstract] [Full Text]
Kim, B.-T., Kitagawa, H., Tamura, J.-i., Saito, T., Kusche-Gullberg, M., Lindahl, U., Sugahara, K. (2001). Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis. Proc. Natl. Acad. Sci. USA 98: 7176-7181 [Abstract] [Full Text]
Karihaloo, A., Karumanchi, S. A., Barasch, J., Jha, V., Nickel, C. H., Yang, J., Grisaru, S., Bush, K. T., Nigam, S., Rosenblum, N. D., Sukhatme, V. P., Cantley, L. G. (2001). Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proc. Natl. Acad. Sci. USA 98: 12509-12514 [Abstract] [Full Text]