Requirement for {beta}-Catenin in Anterior-Posterior Axis Formation in Mice

doi:10.1083/jcb.148.3.567

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© The Rockefeller University Press, 0021-9525/2000//567 $5.00
The Journal of Cell Biology, Volume 148, Number 3, , 2000 567-578

Original Article

Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice

Joerg Huelsken^a, Regina Vogel^a, Volker Brinkmann^a, Bettina Erdmann^a, Carmen Birchmeier^a, and Walter Birchmeier^a

^a Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany
Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, Department of Cell Biology, 13125 Berlin, Germany.49-30-9406-265649-30-9406-3800

wbirch{at}mdc-berlin.de

The anterior-posterior axis of the mouse embryo is defined beforeformation of the primitive streak, and axis specification andsubsequent anterior development involves signaling from bothembryonic ectoderm and visceral endoderm. The Wnt signalingpathway is essential for various developmental processes, buta role in anterior-posterior axis formation in the mouse hasnot been previously established. β-Catenin is a centralplayer in the Wnt pathway and in cadherin-mediated cell adhesion.We generated β-catenin–deficient mouse embryos andobserved a defect in anterior-posterior axis formation at embryonicday 5.5, as visualized by the absence of Hex and Hesx1 and themislocation of cerberus-like and Lim1 expression. Subsequently,no mesoderm and head structures are generated. Intercellularadhesion is maintained since plakoglobin substitutes for β-catenin.Our data demonstrate that β-catenin function is essentialin anterior-posterior axis formation in the mouse, and experimentswith chimeric embryos show that this function is required inthe embryonic ectoderm.

Key Words: anterior visceral endoderm • Wnt/wingless pathway • cell adhesion • plakoglobin • armadillo

Abbreviations used in this paper: BMP, bone morphogenetic protein;E, embryonic day; ES, embryonic stem; LEF, lymphoid enhancerfactor; TCF, T-cell factor.

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