JCB logo
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 359K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guiet, C.
Right arrow Articles by Vito, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guiet, C.
Right arrow Articles by Vito, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

© The Rockefeller University Press, 0021-9525/2000//1131 $5.00
The Journal of Cell Biology, Volume 148, Number 6, , 2000 1131-1140

Brief Report

Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-{kappa}b Activation



Chantal Guieta and Pasquale Vitoa

a Basel Institute for Immunology, Postfach CH-4005, Basel, Switzerland
Basel Institute for Immunology, Grenzacherstrasse 487, Postfach CH-4005, Basel, Switzerland.061-605-1364061-605-1349

Vito{at}bii.ch

Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-{kappa}B. Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential for recruitment of signal transducer molecules-involved NF-{kappa}B activation. We also show that cytoskeleton elements regulate bcl10 signaling.

Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular signaling.

Key Words: bcl10 • filaments • mucosa-associated lymphoid tissue • NF-{kappa}B • scaffold

© 2000 The Rockefeller University Press

Abbreviations used in this paper: CARD, caspase recruitment domain; MALT, mucosa-associated lymphoid tissue; TNF, tumor necrosis factor; TNF-R1, TNF receptor 1.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents