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© The Rockefeller University Press, 0021-9525/2000//1005 $5.00
The Journal of Cell Biology, Volume 149, Number 5, , 2000 1005-1010

Brief Report

Jil-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (Msl) Dosage Compensation Complex



Ye Jina, Yanming Wanga, Jørgen Johansena, and Kristen M. Johansena

a Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011
Department of Zoology and Genetics, 3154 Molecular Biology Building, Iowa State University, Ames, IA 50011.(515) 294-0345(515) 294-7959

kristen{at}iastate.edu

JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL-1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.

Key Words: protein kinase • dosage compensation • Drosophila • chromatin • MSL complex

© 2000 The Rockefeller University Press

The first two authors contributed equally to this work.

Abbreviations used in this paper: GST, glutathione-S-transferase; ip, immunoprecipitation; MSL, male specific lethal.


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