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© The Rockefeller University Press, 0021-9525/2000//567 $5.00
The Journal of Cell Biology, Volume 150, Number 3, , 2000 567-580

P120 Catenin Regulates the Actin Cytoskeleton via Rho Family Gtpases

^a Department of Cell Biology and Anatomy and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599
Department of Cell Biology and Anatomy, 108 Taylor Hall, CB#7090, University of North Carolina, Chapel Hill, NC 27599-7090.(919) 966-1856(919) 966-5783

kburridg{at}med.unc.edu

Cadherins are calcium-dependent adhesion molecules responsible for the establishment of tight cell–cell contacts. p120 catenin (p120ctn) binds to the cytoplasmic domain of cadherins in the juxtamembrane region, which has been implicated in regulating cell motility. It has previously been shown that overexpression of p120ctn induces a dendritic morphology in fibroblasts (Reynolds, A.B., J. Daniel, Y. Mo, J. Wu, and Z. Zhang. 1996. Exp. Cell Res. 225:328–337.). We show here that this phenotype is suppressed by coexpression of cadherin constructs that contain the juxtamembrane region, but not by constructs lacking this domain. Overexpression of p120ctn disrupts stress fibers and focal adhesions and results in a decrease in RhoA activity. The p120ctn-induced phenotype is blocked by dominant negative Cdc42 and Rac1 and by constitutively active Rho-kinase, but is enhanced by dominant negative RhoA. p120ctn overexpression increased the activity of endogenous Cdc42 and Rac1. Exploring how p120ctn may regulate Rho family GTPases, we find that p120ctn binds the Rho family exchange factor Vav2. The behavior of p120ctn suggests that it is a vehicle for cross-talk between cell–cell junctions and the motile machinery of cells. We propose a model in which p120ctn can shuttle between a cadherin-bound state and a cytoplasmic pool in which it can interact with regulators of Rho family GTPases. Factors that perturb cell–cell junctions, such that the cytoplasmic pool of p120ctn is increased, are predicted to decrease RhoA activity but to elevate active Rac1 and Cdc42, thereby promoting cell migration.

Key Words: cadherin • Rac • guanine nucleotide exchange factor • Vav2 • migration

© 2000 The Rockefeller University Press

B. Kreft's present address is Schering AG, Genomics/Bioinformatics, Muellerstr. 178, 13342 Berlin, Germany.

1Abbreviations used in this paper: DN, dominant negative; GAP, GTPase activating proteins; GEF, guanine nucleotide exchange factor; GFP, green fluorescent protein; p120ctn, p120 catenin.

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• Noren, N. K., Arthur, W. T., Burridge, K. (2003). Cadherin Engagement Inhibits RhoA via p190RhoGAP. J. Biol. Chem. 278: 13615-13618 [Abstract] [Full Text]  
• Mareel, M., Leroy, A. (2003). Clinical, Cellular, and Molecular Aspects of Cancer Invasion. Physiol. Rev. 83: 337-376 [Abstract] [Full Text]  
• Lanning, C. C., Ruiz-Velasco, R., Williams, C. L. (2003). Novel Mechanism of the Co-regulation of Nuclear Transport of SmgGDS and Rac1. J. Biol. Chem. 278: 12495-12506 [Abstract] [Full Text]  
• Magie, C. R., Pinto-Santini, D., Parkhurst, S. M. (2003). Rho1 interacts with p120ctn and {alpha}-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development 129: 3771-3782 [Abstract] [Full Text]  
• Lee, S., Kolodziej, P. A. (2003). The plakin Short Stop and the RhoA GTPase are required for E-cadherin-dependent apical surface remodeling during tracheal tube fusion. Development 129: 1509-1520 [Abstract] [Full Text]  
• Gutstein, D. E., Liu, F.-y., Meyers, M. B., Choo, A., Fishman, G. I. (2003). The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions. J. Cell Sci. 116: 875-885 [Abstract] [Full Text]  
• Myster, S. H., Cavallo, R., Anderson, C. T., Fox, D. T., Peifer, M. (2003). Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. JCB 160: 433-449 [Abstract] [Full Text]  
• Yap, A. S., Kovacs, E. M. (2003). Direct cadherin-activated cell signaling: a view from the plasma membrane. JCB 160: 11-16 [Abstract] [Full Text]  
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• Ireton, R. C., Davis, M. A., van Hengel, J., Mariner, D. J., Barnes, K., Thoreson, M. A., Anastasiadis, P. Z., Matrisian, L., Bundy, L. M., Sealy, L., Gilbert, B., van Roy, F., Reynolds, A. B. (2002). A novel role for p120 catenin in E-cadherin function. JCB 159: 465-476 [Abstract] [Full Text]  
• Charrasse, S., Meriane, M., Comunale, F., Blangy, A., Gauthier-Rouviere, C. (2002). N-cadherin-dependent cell-cell contact regulates Rho GTPases and {beta}-catenin localization in mouse C2C12 myoblasts. JCB 158: 953-965 [Abstract] [Full Text]  
• NGUYEN, Q.-D., FAIVRE, S., BRUYNEEL, E., RIVAT, C., SETO, M., ENDO, T., MAREEL, M., EMAMI, S., GESPACH, C. (2002). RhoA- and RhoD-dependent regulatory switch of G{alpha} subunit signaling by PAR-1 receptors in cellular invasion. FASEB J. 16: 565-576 [Abstract] [Full Text]  
• Lampugnani, M. G., Zanetti, A., Breviario, F., Balconi, G., Orsenigo, F., Corada, M., Spagnuolo, R., Betson, M., Braga, V., Dejana, E. (2002). VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam. Mol. Biol. Cell 13: 1175-1189 [Abstract] [Full Text]  
• Chen, X., Bonne, S., Hatzfeld, M., van Roy, F., Green, K. J. (2002). Protein Binding and Functional Characterization of Plakophilin 2. EVIDENCE FOR ITS DIVERSE ROLES IN DESMOSOMES AND beta -CATENIN SIGNALING. J. Biol. Chem. 277: 10512-10522 [Abstract] [Full Text]  
• Kim, S. W., Fang, X., Ji, H., Paulson, A. F., Daniel, J. M., Ciesiolka, M., van Roy, F., McCrea, P. D. (2002). Isolation and Characterization of XKaiso, a Transcriptional Repressor That Associates with the Catenin Xp120ctn in Xenopus laevis. J. Biol. Chem. 277: 8202-8208 [Abstract] [Full Text]  
• Adams, J. C. (2002). Regulation of protrusive and contractile cell-matrix contacts. J. Cell Sci. 115: 257-265 [Abstract] [Full Text]  
• van Wetering, S., van Buul, J. D., Quik, S., Mul, F. P. J., Anthony, E. C., Klooster, J.-P. t., Collard, J. G., Hordijk, P. L. (2002). Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J. Cell Sci. 115: 1837-1846 [Abstract] [Full Text]  
• Aho, S., Levansuo, L., Montonen, O., Kari, C., Rodeck, U., Uitto, J. (2002). Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells. J. Cell Sci. 115: 1391-1402 [Abstract] [Full Text]  
• Montonen, O., Aho, M., Uitto, J., Aho, S. (2001). Tissue Distribution and Cell Type-specific Expression of p120ctn Isoforms. J. Histochem. Cytochem. 49: 1487-1496 [Abstract] [Full Text]  
• Nguyen, B. P., Ren, X.-D., Schwartz, M. A., Carter, W. G. (2001). Ligation of Integrin alpha 3beta 1 by Laminin 5 at the Wound Edge Activates Rho-dependent Adhesion of Leading Keratinocytes on Collagen. J. Biol. Chem. 276: 43860-43870 [Abstract] [Full Text]  
• Xu, X., Li, W.E.I., Huang, G.Y., Meyer, R., Chen, T., Luo, Y., Thomas, M.P., Radice, G.L., Lo, C.W. (2001). Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions. JCB 154: 217-230 [Abstract] [Full Text]  
• Omelchenko, T., Fetisova, E., Ivanova, O., Bonder, E. M., Feder, H., Vasiliev, J. M., Gelfand, I. M. (2001). Contact interactions between epitheliocytes and fibroblasts: Formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization. Proc. Natl. Acad. Sci. USA 10.1073/pnas.151247698v1 [Abstract] [Full Text]  

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