The Dendritic Cell Receptor for Endocytosis, DEC-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II-positive Lysosomal Compartments

doi:10.1083/jcb.151.3.673

Published online 30 October 2000. doi:10.1083/jcb.151.3.673

This Article

	Full Text
	Full Text (PDF, 729K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Mahnke,
	Articles by Steinman, R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Mahnke,
	Articles by Steinman, R.


Social Bookmarking

	What's this?

© The Rockefeller University Press, 0021-9525/2000/10/673/ $5.00
The Journal of Cell Biology, Volume 151, Number 3, October 30, 2000 673-684

Original Article

The Dendritic Cell Receptor for Endocytosis, DEC-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–positive Lysosomal Compartments

Karsten Mahnke^a, Ming Guo^b, Sena Lee^b, Homero Sepulveda^c, Suzy L. Swain^c, Michel Nussenzweig^b, and Ralph M. Steinman^a
^a Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York, 10021
^b Howard Hughes Medical Institute, The Rockefeller University, New York, New York, 10021
^c The Trudeau Institute, Saranac Lake, New York 12983

Correspondence to: Ralph M. Steinman, Laboratory of Cellular Physiology and Immunology, The Rockefeller University, 1230 York Ave., New York, NY, 10021-6399. Tel:(212) 327-8106 Fax:(212) 327-8875

Many receptors for endocytosis recycle into and out of cellsthrough early endosomes. We now find in dendritic cells thatthe DEC-205 multilectin receptor targets late endosomes or lysosomesrich in major histocompatibility complex class II (MHC II) products,whereas the homologous macrophage mannose receptor (MMR), asexpected, is found in more peripheral endosomes. To analyzethis finding, the cytosolic tails of DEC-205 and MMR were fusedto the external domain of the CD16 Fc ${gamma}$ receptor and studied instable L cell transfectants. The two cytosolic domains eachmediated rapid uptake of human immunoglobulin (Ig)G followedby recycling of intact CD16 to the cell surface. However, theDEC-205 tail recycled the CD16 through MHC II–positivelate endosomal/lysosomal vacuoles and also mediated a 100-foldincrease in antigen presentation. The mechanism of late endosomaltargeting, which occurred in the absence of human IgG, involvedtwo functional regions: a membrane-proximal region with a coatedpit sequence for uptake, and a distal region with an EDE triadfor the unusual deeper targeting. Therefore, the DEC-205 cytosolicdomain mediates a new pathway of receptor-mediated endocytosisthat entails efficient recycling through late endosomes anda greatly enhanced efficiency of antigen presentation to CD4⁺T cells.

Key Words: dendritic cell, antigen presentation, DEC-205, MHC class II,endocytosis

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Johnson, T. S., Mahnke, K., Storn, V., Schonfeld, K., Ring, S., Nettelbeck, D. M., Haisma, H. J., Le Gall, F., Kontermann, R. E., Enk, A. H. (2008). Inhibition of Melanoma Growth by Targeting of Antigen to Dendritic Cells via an Anti-DEC-205 Single-Chain Fragment Variable Molecule. Clin. Cancer Res. 14: 8169-8177 [Abstract] [Full Text]
Azad, A. K., Torrelles, J. B., Schlesinger, L. S. (2008). Mutation in the DC-SIGN cytoplasmic triacidic cluster motif markedly attenuates receptor activity for phagocytosis and endocytosis of mannose-containing ligands by human myeloid cells. J. Leukoc. Biol. 84: 1594-1603 [Abstract] [Full Text]
Marshall, F. A., Pearce, E. J. (2008). Uncoupling of Induced Protein Processing from Maturation in Dendritic Cells Exposed to a Highly Antigenic Preparation from a Helminth Parasite. J. Immunol. 181: 7562-7570 [Abstract] [Full Text]
Blander, J M. (2008). Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors. Ann Rheum Dis 67: iii44-iii49 [Abstract] [Full Text]
Weaver, J. M., Lazarski, C. A., Richards, K. A., Chaves, F. A., Jenks, S. A., Menges, P. R., Sant, A. J. (2008). Immunodominance of CD4 T Cells to Foreign Antigens Is Peptide Intrinsic and Independent of Molecular Context: Implications for Vaccine Design. J. Immunol. 181: 3039-3048 [Abstract] [Full Text]
Gurer, C., Strowig, T., Brilot, F., Pack, M., Trumpfheller, C., Arrey, F., Park, C. G., Steinman, R. M., Munz, C. (2008). Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. Blood 112: 1231-1239 [Abstract] [Full Text]
Murphy, J. E., Vohra, R. S., Dunn, S., Holloway, Z. G., Monaco, A. P., Homer-Vanniasinkam, S., Walker, J. H., Ponnambalam, S. (2008). Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2. J. Cell Sci. 121: 2136-2147 [Abstract] [Full Text]
Tacken, P. J., Joosten, B., Reddy, A., Wu, D., Eek, A., Laverman, P., Kretz-Rommel, A., Adema, G. J., Torensma, R., Figdor, C. G. (2008). No Advantage of Cell-Penetrating Peptides over Receptor-Specific Antibodies in Targeting Antigen to Human Dendritic Cells for Cross-Presentation. J. Immunol. 180: 7687-7696 [Abstract] [Full Text]
Higgins, D. M., Sanchez-Campillo, J., Rosas-Taraco, A. G., Higgins, J. R., Lee, E. J., Orme, I. M., Gonzalez-Juarrero, M. (2008). Relative Levels of M-CSF and GM-CSF Influence the Specific Generation of Macrophage Populations during Infection with Mycobacterium tuberculosis. J. Immunol. 180: 4892-4900 [Abstract] [Full Text]
Kato, M., Khan, S., d'Aniello, E., McDonald, K. J., Hart, D. N. J. (2007). The Novel Endocytic and Phagocytic C-Type Lectin Receptor DCL-1/CD302 on Macrophages Is Colocalized with F-Actin, Suggesting a Role in Cell Adhesion and Migration. J. Immunol. 179: 6052-6063 [Abstract] [Full Text]
Angel, C. E., Lala, A., Chen, C.-J. J., Edgar, S. G., Ostrovsky, L. L., Dunbar, P. R. (2007). CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts. Int Immunol 19: 1271-1279 [Abstract] [Full Text]
Mellman, I. (2007). Private Lives: Reflections and Challenges in Understanding the Cell Biology of the Immune System. Science 317: 625-627 [Abstract] [Full Text]
He, L.-Z., Crocker, A., Lee, J., Mendoza-Ramirez, J., Wang, X.-T., Vitale, L. A., O'Neill, T., Petromilli, C., Zhang, H.-F., Lopez, J., Rohrer, D., Keler, T., Clynes, R. (2007). Antigenic Targeting of the Human Mannose Receptor Induces Tumor Immunity. J. Immunol. 178: 6259-6267 [Abstract] [Full Text]
Burgdorf, S., Kautz, A., Bohnert, V., Knolle, P. A., Kurts, C. (2007). Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation. Science 316: 612-616 [Abstract] [Full Text]
McKenzie, E. J., Taylor, P. R., Stillion, R. J., Lucas, A. D., Harris, J., Gordon, S., Martinez-Pomares, L. (2007). Mannose Receptor Expression and Function Define a New Population of Murine Dendritic Cells. J. Immunol. 178: 4975-4983 [Abstract] [Full Text]
Hatsukari, I., Singh, P., Hitosugi, N., Messmer, D., Valderrama, E., Teichberg, S., Chaung, W., Gross, E., Schmidtmayerova, H., Singhal, P. C. (2007). DEC-205-Mediated Internalization of HIV-1 Results in the Establishment of Silent Infection in Renal Tubular Cells. J. Am. Soc. Nephrol. 18: 780-787 [Abstract] [Full Text]
Fallas, J. L., Yi, W., Draghi, N. A., O'Rourke, H. M., Denzin, L. K. (2007). Expression Patterns of H2-O in Mouse B Cells and Dendritic Cells Correlate with Cell Function. J. Immunol. 178: 1488-1497 [Abstract] [Full Text]
Charalambous, A., Oks, M., Nchinda, G., Yamazaki, S., Steinman, R. M. (2006). Dendritic Cell Targeting of Survivin Protein in a Xenogeneic Form Elicits Strong CD4+ T Cell Immunity to Mouse Survivin. J. Immunol. 177: 8410-8421 [Abstract] [Full Text]
Moris, A., Pajot, A., Blanchet, F., Guivel-Benhassine, F., Salcedo, M., Schwartz, O. (2006). Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer. Blood 108: 1643-1651 [Abstract] [Full Text]
Arruda, L. B., Sim, D., Chikhlikar, P. R., Maciel, M. Jr, Akasaki, K., August, J. T., Marques, E. T. A. (2006). Dendritic Cell-Lysosomal-Associated Membrane Protein (LAMP) and LAMP-1-HIV-1 Gag Chimeras Have Distinct Cellular Trafficking Pathways and Prime T and B Cell Responses to a Diverse Repertoire of Epitopes. J. Immunol. 177: 2265-2275 [Abstract] [Full Text]
Carter, R. W., Thompson, C., Reid, D. M., Wong, S. Y. C., Tough, D. F. (2006). Preferential Induction of CD4+ T Cell Responses through In Vivo Targeting of Antigen to Dendritic Cell-Associated C-Type Lectin-1. J. Immunol. 177: 2276-2284 [Abstract] [Full Text]
Mattei, F., Schiavoni, G., Borghi, P., Venditti, M., Canini, I., Sestili, P., Pietraforte, I., Morse, H. C. III, Ramoni, C., Belardelli, F., Gabriele, L. (2006). ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ T cells. Blood 108: 609-617 [Abstract] [Full Text]
Schiavo, R., Baatar, D., Olkhanud, P., Indig, F. E., Restifo, N., Taub, D., Biragyn, A. (2006). Chemokine receptor targeting efficiently directs antigens to MHC class I pathways and elicits antigen-specific CD8+ T-cell responses. Blood 107: 4597-4605 [Abstract] [Full Text]
Kato, M., McDonald, K. J, Khan, S., Ross, I. L, Vuckovic, S., Chen, K., Munster, D., MacDonald, K. P., Hart, D. N. (2006). Expression of human DEC-205 (CD205) multilectin receptor on leukocytes. Int Immunol 18: 857-869 [Abstract] [Full Text]
Trumpfheller, C., Finke, J. S., Lopez, C. B., Moran, T. M., Moltedo, B., Soares, H., Huang, Y., Schlesinger, S. J., Park, C. G., Nussenzweig, M. C., Granelli-Piperno, A., Steinman, R. M. (2006). Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. JEM 203: 607-617 [Abstract] [Full Text]
Mansour, M. K., Latz, E., Levitz, S. M. (2006). Cryptococcus neoformans Glycoantigens Are Captured by Multiple Lectin Receptors and Presented by Dendritic Cells.. J. Immunol. 176: 3053-3061 [Abstract] [Full Text]
Su, Y., Bakker, T., Harris, J., Tsang, C., Brown, G. D., Wormald, M. R., Gordon, S., Dwek, R. A., Rudd, P. M., Martinez-Pomares, L. (2005). Glycosylation Influences the Lectin Activities of the Macrophage Mannose Receptor. J. Biol. Chem. 280: 32811-32820 [Abstract] [Full Text]
Tacken, P. J., de Vries, I. J. M., Gijzen, K., Joosten, B., Wu, D., Rother, R. P., Faas, S. J., Punt, C. J. A., Torensma, R., Adema, G. J., Figdor, C. G. (2005). Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood 106: 1278-1285 [Abstract] [Full Text]
Lozach, P.-Y., Burleigh, L., Staropoli, I., Navarro-Sanchez, E., Harriague, J., Virelizier, J.-L., Rey, F. A., Despres, P., Arenzana-Seisdedos, F., Amara, A. (2005). Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN)-mediated Enhancement of Dengue Virus Infection Is Independent of DC-SIGN Internalization Signals. J. Biol. Chem. 280: 23698-23708 [Abstract] [Full Text]
Le Cabec, V., Emorine, L. J., Toesca, I., Cougoule, C., Maridonneau-Parini, I. (2005). The human macrophage mannose receptor is not a professional phagocytic receptor. J. Leukoc. Biol. 77: 934-943 [Abstract] [Full Text]
Toyama-Sorimachi, N., Omatsu, Y., Onoda, A., Tsujimura, Y., Iyoda, T., Kikuchi-Maki, A., Sorimachi, H., Dohi, T., Taki, S., Inaba, K., Karasuyama, H. (2005). Inhibitory NK Receptor Ly49Q Is Expressed on Subsets of Dendritic Cells in a Cellular Maturation- and Cytokine Stimulation-Dependent Manner. J. Immunol. 174: 4621-4629 [Abstract] [Full Text]
Kamogawa-Schifter, Y., Ohkawa, J., Namiki, S., Arai, N., Arai, K.-i., Liu, Y. (2005). Ly49Q defines 2 pDC subsets in mice. Blood 105: 2787-2792 [Abstract] [Full Text]
Wong, S. H., Santambrogio, L., Strominger, J. L. (2004). Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins. Proc. Natl. Acad. Sci. USA 101: 17783-17788 [Abstract] [Full Text]
Herre, J., Marshall, A. S. J., Caron, E., Edwards, A. D., Williams, D. L., Schweighoffer, E., Tybulewicz, V., Sousa, C. R. e, Gordon, S., Brown, G. D. (2004). Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood 104: 4038-4045 [Abstract] [Full Text]
Napper, C. E., Taylor, M. E. (2004). The mannose receptor fails to enhance processing and presentation of a glycoprotein antigen in transfected fibroblasts. Glycobiology 14: 7C-12C [Abstract] [Full Text]
Tobar, J. A., Gonzalez, P. A., Kalergis, A. M. (2004). Salmonella Escape from Antigen Presentation Can Be Overcome by Targeting Bacteria to Fc{gamma} Receptors on Dendritic Cells. J. Immunol. 173: 4058-4065 [Abstract] [Full Text]
van Broekhoven, C. L., Parish, C. R., Demangel, C., Britton, W. J., Altin, J. G. (2004). Targeting Dendritic Cells with Antigen-Containing Liposomes: A Highly Effective Procedure for Induction of Antitumor Immunity and for Tumor Immunotherapy. Cancer Res. 64: 4357-4365 [Abstract] [Full Text]
Ebner, S., Ehammer, Z., Holzmann, S., Schwingshackl, P., Forstner, M., Stoitzner, P., Huemer, G. M., Fritsch, P., Romani, N. (2004). Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Int Immunol 16: 877-887 [Abstract] [Full Text]
Bonifaz, L. C., Bonnyay, D. P., Charalambous, A., Darguste, D. I., Fujii, S.-I., Soares, H., Brimnes, M. K., Moltedo, B., Moran, T. M., Steinman, R. M. (2004). In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination. JEM 199: 815-824 [Abstract] [Full Text]
Ramakrishna, V., Treml, J. F., Vitale, L., Connolly, J. E., O'Neill, T., Smith, P. A., Jones, C. L., He, L.-Z., Goldstein, J., Wallace, P. K., Keler, T., Endres, M. J. (2004). Mannose Receptor Targeting of Tumor Antigen pmel17 to Human Dendritic Cells Directs Anti-Melanoma T Cell Responses via Multiple HLA Molecules. J. Immunol. 172: 2845-2852 [Abstract] [Full Text]
Cambi, A., de Lange, F., van Maarseveen, N. M., Nijhuis, M., Joosten, B., van Dijk, E. M.H.P., de Bakker, B. I., Fransen, J. A.M., Bovee-Geurts, P. H.M., van Leeuwen, F. N., Van Hulst, N. F., Figdor, C. G. (2004). Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells. JCB 164: 145-155 [Abstract] [Full Text]
Hart, J. P., Gunn, M. D., Pizzo, S. V. (2004). A CD91-Positive Subset of CD11c+ Blood Dendritic Cells: Characterization of the APC that Functions to Enhance Adaptive Immune Responses against CD91-Targeted Antigens. J. Immunol. 172: 70-78 [Abstract] [Full Text]
Chieppa, M., Bianchi, G., Doni, A., Del Prete, A., Sironi, M., Laskarin, G., Monti, P., Piemonti, L., Biondi, A., Mantovani, A., Introna, M., Allavena, P. (2003). Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program. J. Immunol. 171: 4552-4560 [Abstract] [Full Text]
Gardner, L., Moffett, A. (2003). Dendritic Cells in the Human Decidua. Biol. Reprod. 69: 1438-1446 [Abstract] [Full Text]
Kato, M., Khan, S., Gonzalez, N., O'Neill, B. P., McDonald, K. J., Cooper, B. J., Angel, N. Z., Hart, D. N. J. (2003). Hodgkin's Lymphoma Cell Lines Express a Fusion Protein Encoded by Intergenically Spliced mRNA for the Multilectin Receptor DEC-205 (CD205) and a Novel C-type Lectin Receptor DCL-1. J. Biol. Chem. 278: 34035-34041 [Abstract] [Full Text]
Porcaro, I., Vidal, M., Jouvert, S., Stahl, P. D., Giaimis, J. (2003). Mannose receptor contribution to Candida albicans phagocytosis by murine E-clone J774 macrophages. J. Leukoc. Biol. 74: 206-215 [Abstract] [Full Text]
Mahnke, K., Qian, Y., Knop, J., Enk, A. H. (2003). Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood 101: 4862-4869 [Abstract] [Full Text]
Appelmelk, B. J., van Die, I., van Vliet, S. J., Vandenbroucke-Grauls, C. M. J. E., Geijtenbeek, T. B. H., van Kooyk, Y. (2003). Cutting Edge: Carbohydrate Profiling Identifies New Pathogens That Interact with Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin on Dendritic Cells. J. Immunol. 170: 1635-1639 [Abstract] [Full Text]
Small, M., Kraal, G. (2003). In vitro evidence for participation of DEC-205 expressed by thymic cortical epithelial cells in clearance of apoptotic thymocytes. Int Immunol 15: 197-203 [Abstract] [Full Text]
East, L., Rushton, S., Taylor, M. E., Isacke, C. M. (2002). Characterization of Sugar Binding by the Mannose Receptor Family Member, Endo180. J. Biol. Chem. 277: 50469-50475 [Abstract] [Full Text]
Bonifaz, L., Bonnyay, D., Mahnke, K., Rivera, M., Nussenzweig, M. C., Steinman, R. M. (2002). Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance. JEM 196: 1627-1638 [Abstract] [Full Text]
MacDonald, K. P. A., Munster, D. J., Clark, G. J., Dzionek, A., Schmitz, J., Hart, D. N. J. (2002). Characterization of human blood dendritic cell subsets. Blood 100: 4512-4520 [Abstract] [Full Text]
Ryan, E. J., Marshall, A. J., Magaletti, D., Floyd, H., Draves, K. E., Olson, N. E., Clark, E. A. (2002). Dendritic Cell-Associated Lectin-1: A Novel Dendritic Cell-Associated, C-Type Lectin-Like Molecule Enhances T Cell Secretion of IL-4. J. Immunol. 169: 5638-5648 [Abstract] [Full Text]
Messmer, D., Jacque, J.-M., Santisteban, C., Bristow, C., Han, S.-Y., Villamide-Herrera, L., Mehlhop, E., Marx, P. A., Steinman, R. M., Gettie, A., Pope, M. (2002). Endogenously Expressed nef Uncouples Cytokine and Chemokine Production from Membrane Phenotypic Maturation in Dendritic Cells. J. Immunol. 169: 4172-4182 [Abstract] [Full Text]
Geijtenbeek, T. B. H., Groot, P. C., Nolte, M. A., van Vliet, S. J., Gangaram-Panday, S. T., van Duijnhoven, G. C. F., Kraal, G., van Oosterhout, A. J. M., van Kooyk, Y. (2002). Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Blood 100: 2908-2916 [Abstract] [Full Text]
Howard, M. J., Isacke, C. M. (2002). The C-type Lectin Receptor Endo180 Displays Internalization and Recycling Properties Distinct from Other Members of the Mannose Receptor Family. J. Biol. Chem. 277: 32320-32331 [Abstract] [Full Text]
Denda-Nagai, K., Kubota, N., Tsuiji, M., Kamata, M., Irimura, T. (2002). Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of glycosylated antigens. Glycobiology 12: 443-450 [Abstract] [Full Text]
Takahara, K., Omatsu, Y., Yashima, Y., Maeda, Y., Tanaka, S., Iyoda, T., Clusen, B., Matsubara, K., Letterio, J., Steinman, R. M., Matsuda, Y., Inaba, K. (2002). Identification and expression of mouse Langerin (CD207) in dendritic cells. Int Immunol 14: 433-444 [Abstract] [Full Text]
Mansour, M. K., Schlesinger, L. S., Levitz, S. M. (2002). Optimal T Cell Responses to Cryptococcus neoformans Mannoprotein Are Dependent on Recognition of Conjugated Carbohydrates by Mannose Receptors. J. Immunol. 168: 2872-2879 [Abstract] [Full Text]
Engering, A., Geijtenbeek, T. B. H., van Vliet, S. J., Wijers, M., van Liempt, E., Demaurex, N., Lanzavecchia, A., Fransen, J., Figdor, C. G., Piguet, V., van Kooyk, Y. (2002). The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells. J. Immunol. 168: 2118-2126 [Abstract] [Full Text]
Frank, I., Piatak, M. Jr., Stoessel, H., Romani, N., Bonnyay, D., Lifson, J.D., Pope, M. (2002). Infectious and Whole Inactivated Simian Immunodeficiency Viruses Interact Similarly with Primate Dendritic Cells (DCs): Differential Intracellular Fate of Virions in Mature and Immature DCs. J. Virol. 76: 2936-2951 [Abstract] [Full Text]
Valladeau, J., Clair-Moninot, V., Dezutter-Dambuyant, C., Pin, J.-J., Kissenpfennig, A., Mattei, M.-G., Ait-Yahia, S., Bates, E. E. M., Malissen, B., Koch, F., Fossiez, F., Romani, N., Lebecque, S., Saeland, S. (2002). Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues. J. Immunol. 168: 782-792 [Abstract] [Full Text]
Steinman, R. M., Nussenzweig, M. C. (2002). Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 10.1073/pnas.231606698v1 [Abstract] [Full Text]
Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J. V., Steinman, R. M., Nussenzweig, M. C. (2001). Dendritic Cells Induce Peripheral T Cell Unresponsiveness Under Steady State Conditions In Vivo. JEM 194: 769-780 [Abstract] [Full Text]
Napper, C. E., Dyson, M. H., Taylor, M. E. (2001). An Extended Conformation of the Macrophage Mannose Receptor. J. Biol. Chem. 276: 14759-14766 [Abstract] [Full Text]
Steinman, R. M., Nussenzweig, M. C. (2002). Inaugural Article: Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 99: 351-358 [Abstract] [Full Text]