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© The Rockefeller University Press,
0021-9525/2001//1307 $5.00
The Journal of Cell Biology, Volume 152, Number 6,
, 2001 1307-1312
Report |
Importin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor
: Role in Cell Proliferation
Dept. of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., CAL-3, La Jolla, CA 92037.(858) 784-7675(858) 784-7712
pmaher{at}scripps.edu
Although growth factor receptors are generally thought to carry out their role in signal transduction at the cell surface, many of these transmembrane proteins translocate to the nucleus after ligand stimulation. Here, we show that the nuclear translocation of fibroblast growth factor receptor (FGFR)1 occurs via a mechanism distinct from classical nuclear import but dependent on importin β, a component of multiple nuclear import pathways. Furthermore, we show that nuclear FGFR1 induces c-Jun and is involved in the regulation of cell proliferation. These data are the first description of a nuclear import pathway for transmembrane growth factor receptors and elucidate a novel signal transduction pathway from the cell surface to the nucleus.
Key Words: FGF receptor • importin β • nuclear transport • c Jun • cyclin D1
© 2001 The Rockefeller University Press
J.F. Reilly's present address is Neurome, Inc., 11149 N. Torrey Pines Rd., La Jolla, CA 92037. Tel.: (858) 677-0466. Fax: (858) 677-0458. E-mail: jreilly{at}neurome.comAbbreviations used in this paper: FGFR, FGF receptor; NLS, nuclear localization signal.
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