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Published online 14 May 2001. doi:10.1083/jcb.153.4.677
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© The Rockefeller University Press, 0021-9525/2001//677 $5.00
The Journal of Cell Biology, Volume 153, Number 4, , 2001 677-686

Original Article

Human Myoblast Fusion Requires Expression of Functional Inward Rectifier Kir2.1 Channels



Jacqueline Fischer-Lougheeda, Jian-Hui Liua,c, Estelle Espinosa, David Mordasinia, Charles R. Baderc, Dominique Belinb, and Laurent Bernheima

a Département de Physiologie et, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland
b Département de Pathologie, Centre Médical Universitaire, CH-1211 Geneva 4, Switzerland
c Division de Recherche Clinique Neuro-Musculaire, Département des Neurosciences Cliniques et Dermatologie, Hôpital Cantonal Universitaire, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Département de Physiologie, Centre Médical Universitaire, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.(41) 22 702 53 92

Myoblast fusion is essential to skeletal muscle development and repair. We have demonstrated previously that human myoblasts hyperpolarize, before fusion, through the sequential expression of two K+ channels: an ether-à-go-go and an inward rectifier. This hyperpolarization is a prerequisite for fusion, as it sets the resting membrane potential in a range at which Ca2+ can enter myoblasts and thereby trigger fusion via a window current through {alpha}1H T channels.

Key Words: potassium current • membrane potential • myoblast fusion • muscle • antisense

© 2001 The Rockefeller University Press

Abbreviations used in this paper: DM, differentiation medium; EGFP, enhanced green fluorescent protein; FCMB, fusion-competent myoblast; GM, growth medium.


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