Nuclear pore complexes: dynamics in unexpected places

doi:10.1083/jcb.200106071

Published 9 July 2001. doi:10.1083/jcb.200106071

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© The Rockefeller University Press, 0021-9525/2001/7/17 $5.00
The Journal of Cell Biology, Volume 154, Number 1, July 9, 2001 17-20

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Nuclear pore complexes: dynamics in unexpected places

Susan K. Lyman and Larry Gerace

Departments of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037

Address correspondence to Larry Gerace, Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Tel.: (858) 784-8514. Fax: (858) 784-9132. E-mail: lgerace{at}scripps.edu

In vivo studies on the dynamics of the nuclear pore complex(NPC) in yeast suggested that NPCs are highly mobile in thenuclear envelope. However, new evidence indicates that in mammaliancells NPCs are stably attached to a flexible lamina framework,but a peripheral component can exchange rapidly with an intranuclearpool.

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