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Published 23 July 2001. doi:10.1083/jcb.200106124
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© The Rockefeller University Press, 0021-9525/2001/7/257 $5.00
The Journal of Cell Biology, Volume 154, Number 2, July 23, 2001 257-260

Comment

Mystery solved

: discovery of a novel integrin ligand in the developing kidney



Jeffrey H. Miner

Department of Internal Medicine/Renal Division, and Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110

Address correspondence to Jeffrey H. Miner, Washington University School of Medicine, Renal Division, Box 8126, 660 South Euclid Ave., St. Louis, MO 63110. Tel.: (314) 362-8235. Fax: (314) 362-8237. E-mail: minerj{at}pcg.wustl.edu

Mutant mice lacking the integrin {alpha}8 subunit exhibit variable defects in kidney development with most mutants missing both kidneys. Several lines of evidence indicate that the known extracellular matrix ligands for integrin {alpha}8ß1 are either dispensable for or not involved in {alpha}8ß1 signaling during kidney development. This suggests the presence of an unknown ligand. A novel {alpha}8ß1 ligand, nephronectin, has now been identified. Nephronectin is a new extracellular matrix protein associated with the Wolffian duct and the ureteric bud, epithelial structures with well-defined roles in kidney development.


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