Hsp90: a specialized but essential protein-folding tool

doi:10.1083/jcb.200104079

Published 23 July 2001. doi:10.1083/jcb.200104079

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© The Rockefeller University Press, 0021-9525/2001/7/267 $5.00
The Journal of Cell Biology, Volume 154, Number 2, July 23, 2001 267-274

Mini-Reviews

Hsp90

: a specialized but essential protein-folding tool

Jason C. Young, Ismail Moarefi and F. Ulrich Hartl

Cellular Biochemistry, Max Planck Institute for Biochemistry, Martinsried D-82152, Germany

Address correspondence to Ulrich Hartl, Dept. of Cellular Biochemistry, Max-Planck-Institut für Biochemie, Am Kopferspitz 18a, Martinsried D-82152, Germany. Tel.: 49-89-8578-2233. Fax: 49-89-8578-2211. E-mail: uhartl{at}biochem.mpg.de

Abstract

Hsp90 is unique among molecular chaperones. The majority ofits known substrates are signal transduction proteins, and recentwork indicates that it uses a novel protein-folding strategy.

Key Words: Hsp90; molecular chaperones; protein folding; signal transduction; ansamycin

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Pi, X., Patterson, C. (2008). Twin Layers of Lightning: A New Role for the Chaperone Hsp90 in Angiogenesis. Arterioscler. Thromb. Vasc. Bio. 28: 6-7 [Full Text]
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Samakovli, D., Thanou, A., Valmas, C., Hatzopoulos, P. (2007). Hsp90 canalizes developmental perturbation. J Exp Bot 58: 3513-3524 [Abstract] [Full Text]
Stahl, M., Retzlaff, M., Nassal, M., Beck, J. (2007). Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system. Nucleic Acids Res 35: 6124-6136 [Abstract] [Full Text]
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Camphausen, K., Tofilon, P. J. (2007). Inhibition of Hsp90: A Multitarget Approach to Radiosensitization. Clin. Cancer Res. 13: 4326-4330 [Abstract] [Full Text]
Lei, H., Venkatakrishnan, A., Yu, S., Kazlauskas, A. (2007). Protein Kinase A-dependent Translocation of Hsp90{alpha} Impairs Endothelial Nitric-oxide Synthase Activity in High Glucose and Diabetes. J. Biol. Chem. 282: 9364-9371 [Abstract] [Full Text]
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Uchiyama, Y., Takeda, N., Mori, M., Terada, K. (2006). Heat Shock Protein 40/DjB1 Is Required for Thermotolerance in Early Phase. J Biochem 140: 805-812 [Abstract] [Full Text]
Hawle, P., Siepmann, M., Harst, A., Siderius, M., Reusch, H. P., Obermann, W. M. J. (2006). The Middle Domain of Hsp90 Acts as a Discriminator between Different Types of Client Proteins. Mol. Cell. Biol. 26: 8385-8395 [Abstract] [Full Text]
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Nowakowski, G. S., McCollum, A. K., Ames, M. M., Mandrekar, S. J., Reid, J. M., Adjei, A. A., Toft, D. O., Safgren, S. L., Erlichman, C. (2006). A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer.. Clin. Cancer Res. 12: 6087-6093 [Abstract] [Full Text]
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Willmund, F., Schroda, M. (2005). HEAT SHOCK PROTEIN 90C Is a Bona Fide Hsp90 That Interacts with Plastidic HSP70B in Chlamydomonas reinhardtii. Plant Physiol. 138: 2310-2322 [Abstract] [Full Text]
Liman, J., Ganesan, S., Dohm, C. P., Krajewski, S., Reed, J. C., Bahr, M., Wouters, F. S., Kermer, P. (2005). Interaction of BAG1 and Hsp70 Mediates Neuroprotectivity and Increases Chaperone Activity. Mol. Cell. Biol. 25: 3715-3725 [Abstract] [Full Text]
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Terasawa, K., Minami, M., Minami, Y. (2005). Constantly Updated Knowledge of Hsp90. J Biochem 137: 443-447 [Abstract] [Full Text]
Muller, P., Ceskova, P., Vojtesek, B. (2005). Hsp90 Is Essential for Restoring Cellular Functions of Temperature-sensitive p53 Mutant Protein but Not for Stabilization and Activation of Wild-type p53: IMPLICATIONS FOR CANCER THERAPY. J. Biol. Chem. 280: 6682-6691 [Abstract] [Full Text]
Goetz, M. P., Toft, D., Reid, J., Ames, M., Stensgard, B., Safgren, S., Adjei, A. A., Sloan, J., Atherton, P., Vasile, V., Salazaar, S., Adjei, A., Croghan, G., Erlichman, C. (2005). Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer. JCO 23: 1078-1087 [Abstract] [Full Text]
Huang, Z., Somanath, P. R., Chakrabarti, R., Eddy, E. M., Vijayaraghavan, S. (2005). Changes in Intracellular Distribution and Activity of Protein Phosphatase PP1{gamma}2 and Its Regulating Proteins in Spermatozoa Lacking AKAP4. Biol. Reprod. 72: 384-392 [Abstract] [Full Text]
WORKMAN, P. (2005). Drugging the Cancer Kinome: Progress and Challenges in Developing Personalized Molecular Cancer Therapeutics. Cold Spring Harb Symp Quant Biol 70: 499-515 [Abstract]
Walerych, D., Kudla, G., Gutkowska, M., Wawrzynow, B., Muller, L., King, F. W., Helwak, A., Boros, J., Zylicz, A., Zylicz, M. (2004). Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein. J. Biol. Chem. 279: 48836-48845 [Abstract] [Full Text]
Guisbert, E., Herman, C., Lu, C. Z., Gross, C. A. (2004). A chaperone network controls the heat shock response in E. coli. Genes Dev. 18: 2812-2821 [Abstract] [Full Text]
Youker, R. T., Walsh, P., Beilharz, T., Lithgow, T., Brodsky, J. L. (2004). Distinct Roles for the Hsp40 and Hsp90 Molecular Chaperones during Cystic Fibrosis Transmembrane Conductance Regulator Degradation in Yeast. Mol. Biol. Cell 15: 4787-4797 [Abstract] [Full Text]
Whittier, J. E., Xiong, Y., Rechsteiner, M. C., Squier, T. C. (2004). Hsp90 Enhances Degradation of Oxidized Calmodulin by the 20 S Proteasome. J. Biol. Chem. 279: 46135-46142 [Abstract] [Full Text]
Masuda, Y., Shima, G., Aiuchi, T., Horie, M., Hori, K., Nakajo, S., Kajimoto, S., Shibayama-Imazu, T., Nakaya, K. (2004). Involvement of Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) in Apoptosis Induced by {beta}-Hydroxyisovalerylshikonin. J. Biol. Chem. 279: 42503-42515 [Abstract] [Full Text]
Schilb, A., Riou, V., Schoepfer, J., Ottl, J., Muller, K., Chene, P., Mayr, L. M., Filipuzzi, I. (2004). Development and Implementation of a Highly Miniaturized Confocal 2D-FIDA-Based High-Throughput Screening Assay to Search for Active Site Modulators of the Human Heat Shock Protein 90{beta}. J Biomol Screen 9: 569-577 [Abstract]
van Heyningen, V., Yeyati, P. L. (2004). Mechanisms of non-Mendelian inheritance in genetic disease. Hum Mol Genet 13: R225-R233 [Abstract] [Full Text]
Giannini, A., Bijlmakers, M.-J. (2004). Regulation of the Src Family Kinase Lck by Hsp90 and Ubiquitination. Mol. Cell. Biol. 24: 5667-5676 [Abstract] [Full Text]
Braga-Basaria, M., Hardy, E., Gottfried, R., Burman, K. D., Saji, M., Ringel, M. D. (2004). 17-Allylamino-17-Demethoxygeldanamycin Activity against Thyroid Cancer Cell Lines Correlates with Heat Shock Protein 90 Levels. J. Clin. Endocrinol. Metab. 89: 2982-2988 [Abstract] [Full Text]
Yan, L., Cerny, R. L., Cirillo, J. D. (2004). Evidence that hsp90 Is Involved in the Altered Interactions of Acanthamoeba castellanii Variants with Bacteria. Eukaryot Cell 3: 567-578 [Abstract] [Full Text]
ZHU, S., TYTGAT, J. (2004). Evolutionary epitopes of Hsp90 and p23: implications for their interaction. FASEB J. 18: 940-947 [Abstract] [Full Text]
Hainzl, O., Wegele, H., Richter, K., Buchner, J. (2004). Cns1 Is an Activator of the Ssa1 ATPase Activity. J. Biol. Chem. 279: 23267-23273 [Abstract] [Full Text]
Bonvini, P., Rosa, H. D., Vignes, N., Rosolen, A. (2004). Ubiquitination and Proteasomal Degradation of Nucleophosmin-Anaplastic Lymphoma Kinase Induced by 17-Allylamino-Demethoxygeldanamycin: Role of the Co-Chaperone Carboxyl Heat Shock Protein 70-Interacting Protein. Cancer Res. 64: 3256-3264 [Abstract] [Full Text]
Kaufman, B., Scharf, O., Arbeit, J., Ashcroft, M., Brown, J. M., Bruick, R. K., Chapman, J. D., Evans, S. M., Giaccia, A. J., Harris, A. L., Huang, E., Johnson, R., Kaelin, W. Jr., Koch, C. J., Maxwell, P., Mitchell, J., Neckers, L., Powis, G., Rajendran, J., Semenza, G. L., Simons, J., Storkebaum, E., Welch, M. J., Whitelaw, M., Melillo, G., Ivy, S. P. (2004). Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Res. 64: 3350-3356 [Abstract] [Full Text]
Matsuda, N., Mishina, M. (2004). Identification of chaperonin CCT{gamma} subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant. Development 131: 1913-1925 [Abstract] [Full Text]
Lee, Y.-T., Jacob, J., Michowski, W., Nowotny, M., Kuznicki, J., Chazin, W. J. (2004). Human Sgt1 Binds HSP90 through the CHORD-Sgt1 Domain and Not the Tetratricopeptide Repeat Domain. J. Biol. Chem. 279: 16511-16517 [Abstract] [Full Text]
Hayward, S. A. L., Rinehart, J. P., Denlinger, D. L. (2004). Desiccation and rehydration elicit distinct heat shock protein transcript responses in flesh fly pupae. J. Exp. Biol. 207: 963-971 [Abstract] [Full Text]
Okada, M., Hatakeyama, T., Itoh, H., Tokuta, N., Tokumitsu, H., Kobayashi, R. (2004). S100A1 Is a Novel Molecular Chaperone and a Member of the Hsp70/Hsp90 Multichaperone Complex. J. Biol. Chem. 279: 4221-4233 [Abstract] [Full Text]
Srikakulam, R., Winkelmann, D. A. (2004). Chaperone-mediated folding and assembly of myosin in striated muscle. J. Cell Sci. 117: 641-652 [Abstract] [Full Text]
Liu, Y., Burch-Smith, T., Schiff, M., Feng, S., Dinesh-Kumar, S. P. (2004). Molecular Chaperone Hsp90 Associates with Resistance Protein N and Its Signaling Proteins SGT1 and Rar1 to Modulate an Innate Immune Response in Plants. J. Biol. Chem. 279: 2101-2108 [Abstract] [Full Text]
Luo, J., Benovic, J. L. (2003). G Protein-coupled Receptor Kinase Interaction with Hsp90 Mediates Kinase Maturation. J. Biol. Chem. 278: 50908-50914 [Abstract] [Full Text]
Wu, J.-M., Xiao, L., Cheng, X.-K., Cui, L.-X., Wu, N.-H., Shen, Y.-F. (2003). PKC{epsilon} Is a Unique Regulator for hsp90{beta} Gene in Heat Shock Response. J. Biol. Chem. 278: 51143-51149 [Abstract] [Full Text]
Rahmani, M., Yu, C., Dai, Y., Reese, E., Ahmed, W., Dent, P., Grant, S. (2003). Coadministration of the Heat Shock Protein 90 Antagonist 17-Allylamino- 17-demethoxygeldanamycin with Suberoylanilide Hydroxamic Acid or Sodium Butyrate Synergistically Induces Apoptosis in Human Leukemia Cells. Cancer Res. 63: 8420-8427 [Abstract] [Full Text]
Fortugno, P., Beltrami, E., Plescia, J., Fontana, J., Pradhan, D., Marchisio, P. C., Sessa, W. C., Altieri, D. C. (2003). Regulation of survivin function by Hsp90. Proc. Natl. Acad. Sci. USA 100: 13791-13796 [Abstract] [Full Text]
Milton, C. C., Huynh, B., Batterham, P., Rutherford, S. L., Hoffmann, A. A. (2003). Quantitative trait symmetry independent of Hsp90 buffering: Distinct modes of genetic canalization and developmental stability. Proc. Natl. Acad. Sci. USA 100: 13396-13401 [Abstract] [Full Text]
Rosenhagen, M. C., Soti, C., Schmidt, U., Wochnik, G. M., Hartl, F. U., Holsboer, F., Young, J. C., Rein, T. (2003). The Heat Shock Protein 90-Targeting Drug Cisplatin Selectively Inhibits Steroid Receptor Activation. Mol. Endocrinol. 17: 1991-2001 [Abstract] [Full Text]
Beck, J., Nassal, M. (2003). Efficient Hsp90-independent in Vitro Activation by Hsc70 and Hsp40 of Duck Hepatitis B Virus Reverse Transcriptase, an Assumed Hsp90 Client Protein. J. Biol. Chem. 278: 36128-36138 [Abstract] [Full Text]
Sreedhar, A. S., Mihaly, K., Pato, B., Schnaider, T., Stetak, A., Kis-Petik, K., Fidy, J., Simonics, T., Maraz, A., Csermely, P. (2003). Hsp90 Inhibition Accelerates Cell Lysis: ANTI-Hsp90 RIBOZYME REVEALS A COMPLEX MECHANISM OF Hsp90 INHIBITORS INVOLVING BOTH SUPEROXIDE- AND Hsp90-DEPENDENT EVENTS. J. Biol. Chem. 278: 35231-35240 [Abstract] [Full Text]
Jia, W., Yu, C., Rahmani, M., Krystal, G., Sausville, E. A., Dent, P., Grant, S. (2003). Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Blood 102: 1824-1832 [Abstract] [Full Text]
Tesic, M., Marsh, J. A., Cullinan, S. B., Gaber, R. F. (2003). Functional Interactions between Hsp90 and the Co-chaperones Cns1 and Cpr7 in Saccharomyces cerevisiae. J. Biol. Chem. 278: 32692-32701 [Abstract] [Full Text]
Haug, G., Leemhuis, J., Tiemann, D., Meyer, D. K., Aktories, K., Barth, H. (2003). The Host Cell Chaperone Hsp90 Is Essential for Translocation of the Binary Clostridium botulinum C2 Toxin into the Cytosol. J. Biol. Chem. 278: 32266-32274 [Abstract] [Full Text]
Goetz, M. P., Toft, D. O., Ames, M. M., Erlichman, C. (2003). The Hsp90 chaperone complex as a novel target for cancer therapy. Ann Oncol 14: 1169-1176 [Abstract] [Full Text]
Wegele, H., Haslbeck, M., Reinstein, J., Buchner, J. (2003). Sti1 Is a Novel Activator of the Ssa Proteins. J. Biol. Chem. 278: 25970-25976 [Abstract] [Full Text]
Ficker, E., Dennis, A. T., Wang, L., Brown, A. M. (2003). Role of the Cytosolic Chaperones Hsp70 and Hsp90 in Maturation of the Cardiac Potassium Channel hERG. Circ. Res. 92 : e87-e100 [Abstract] [Full Text]
Lotz, G. P., Lin, H., Harst, A., Obermann, W. M. J. (2003). Aha1 Binds to the Middle Domain of Hsp90, Contributes to Client Protein Activation, and Stimulates the ATPase Activity of the Molecular Chaperone. J. Biol. Chem. 278: 17228-17235 [Abstract] [Full Text]
Lemichez, E., Boquet, P. (2003). To be helped or not helped, that is the question. JCB 160: 991-992 [Abstract] [Full Text]
Richter, K., Muschler, P., Hainzl, O., Reinstein, J., Buchner, J. (2003). Sti1 Is a Non-competitive Inhibitor of the Hsp90 ATPase. BINDING PREVENTS THE N-TERMINAL DIMERIZATION REACTION DURING THE ATPASE CYCLE. J. Biol. Chem. 278: 10328-10333 [Abstract] [Full Text]
Pratt, W. B., Toft, D. O. (2003). Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery. Exp. Biol. Med. 228: 111-133 [Abstract] [Full Text]
Zhang, Z., Quick, M. K., Kanelakis, K. C., Gijzen, M., Krishna, P. (2003). Characterization of a Plant Homolog of Hop, a Cochaperone of Hsp90. Plant Physiol. 131: 525-535 [Abstract] [Full Text]
Sullivan, W. P., Owen, B. A. L., Toft, D. O. (2002). The Influence of ATP and p23 on the Conformation of hsp90. J. Biol. Chem. 277: 45942-45948 [Abstract] [Full Text]
Hernandez, M. P., Sullivan, W. P., Toft, D. O. (2002). The Assembly and Intermolecular Properties of the hsp70-Hop-hsp90 Molecular Chaperone Complex. J. Biol. Chem. 277: 38294-38304 [Abstract] [Full Text]
Saitoh, T., Yanagita, T., Shiraishi, S., Yokoo, H., Kobayashi, H., Minami, S.-i., Onitsuka, T., Wada, A. (2002). Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate-1 Phosphorylation by Inhibitor of 90-kDa Heat-Shock Protein Family: Endoplasmic Reticulum Retention of Monomeric Insulin Receptor Precursor with Calnexin in Adrenal Chromaffin Cells. Mol. Pharmacol. 62: 847-855 [Abstract] [Full Text]
Waheed, A. A., Jones, T. L. Z. (2002). Hsp90 Interactions and Acylation Target the G Protein Galpha 12 but Not Galpha 13 to Lipid Rafts. J. Biol. Chem. 277: 32409-32412 [Abstract] [Full Text]
Francischetti, I. M. B., Valenzuela, J. G., Pham, V. M., Garfield, M. K., Ribeiro, J. M. C. (2002). Toward a catalog for the transcripts and proteins (sialome) from the salivary gland of the malaria vector Anopheles gambiae. J. Exp. Biol. 205: 2429-2451 [Abstract] [Full Text]
Dubacq, C., Guerois, R., Courbeyrette, R., Kitagawa, K., Mann, C. (2002). Sgt1p Contributes to Cyclic AMP Pathway Activity and Physically Interacts with the Adenylyl Cyclase Cyr1p/Cdc35p in Budding Yeast. Eukaryot Cell 1: 568-582 [Abstract] [Full Text]
Yamano, T., Murata, S., Shimbara, N., Tanaka, N., Chiba, T., Tanaka, K., Yui, K., Udono, H. (2002). Two Distinct Pathways Mediated by PA28 and hsp90 in Major Histocompatibility Complex Class I Antigen Processing. JEM 196: 185-196 [Abstract] [Full Text]
Nollen, E. A. A., Morimoto, R. I. (2002). Chaperoning signaling pathways: molecular chaperones as stress-sensing `heat shock' proteins. J. Cell Sci. 115: 2809-2816 [Abstract] [Full Text]
Artigues, A., Iriarte, A., Martinez-Carrion, M. (2002). Binding to Chaperones Allows Import of a Purified Mitochondrial Precursor into Mitochondria. J. Biol. Chem. 277: 25047-25055 [Abstract] [Full Text]
Wang, X., Grammatikakis, N., Hu, J. (2002). Role of p50/CDC37 in Hepadnavirus Assembly and Replication. J. Biol. Chem. 277: 24361-24367 [Abstract] [Full Text]
Panchuk, I. I., Volkov, R. A., Schoffl, F. (2002). Heat Stress- and Heat Shock Transcription Factor-Dependent Expression and Activity of Ascorbate Peroxidase in Arabidopsis. Plant Physiol. 129: 838-853 [Abstract] [Full Text]
Brinker, A., Scheufler, C., von der Mulbe, F., Fleckenstein, B., Herrmann, C., Jung, G., Moarefi, I., Hartl, F. U. (2002). Ligand Discrimination by TPR Domains. RELEVANCE AND SELECTIVITY OF EEVD-RECOGNITION IN Hsp70{middle dot}Hop{middle dot}Hsp90 COMPLEXES. J. Biol. Chem. 277: 19265-19275 [Abstract] [Full Text]
Hartl, F. U., Hayer-Hartl, M. (2002). Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein. Science 295: 1852-1858 [Abstract] [Full Text]
Owen, B. A. L., Sullivan, W. P., Felts, S. J., Toft, D. O. (2002). Regulation of Heat Shock Protein 90 ATPase Activity by Sequences in the Carboxyl Terminus. J. Biol. Chem. 277: 7086-7091 [Abstract] [Full Text]
Mergny, J.-L., Riou, J.-F., Mailliet, P., Teulade-Fichou, M.-P., Gilson, E. (2002). Natural and pharmacological regulation of telomerase. Nucleic Acids Res 30: 839-865 [Abstract] [Full Text]
Hung, J.-J., Chung, C.-S., Chang, W. (2002). Molecular Chaperone Hsp90 Is Important for Vaccinia Virus Growth in Cells. J. Virol. 76: 1379-1390 [Abstract] [Full Text]