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© The Rockefeller University Press, 0021-9525/2001/9/909 $5.00
The Journal of Cell Biology, Volume 154, Number 5, September 3, 2001 909-912

A new view of the spindle checkpoint

Department of Biology, The Johns Hopkins University, Baltimore, MD 21218

Address correspondence to M. Andrew Hoyt, Dept. of Biology, Mudd Hall, Rm. 36, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218. Tel.: (410) 516-7299. Fax: (410) 516- 5213. E-mail: hoyt{at}jhu.edu

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.

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