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© The Rockefeller University Press, 0021-9525/2001/9/1105 $5.00
The Journal of Cell Biology, Volume 154, Number 6, September 17, 2001 1105-1110

Where is APC going?

¹ KAN Research Institute, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8815, Japan
² Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo-ku, Kyoto 600-8813, Japan
³ Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8315, Japan

Address correspondence to Shoichiro Tsukita, Dept. of Cell Biology, Kyoto University Faculty of Medicine, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8315, Japan. Tel.: 81-75-753-4372. Fax: 81-75-753-4660. E-mail: htsukita{at}mfour.med.kyoto-u.ac.jp

Abstract

Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/ß-catenin signaling pathway. However, its connections to the cytoskeleton and microtubules in particular are becoming apparent, and the discovery of these new functions for APC is leading to a reevaluation of its role not only in tumorigenesis, but also in normal physiology.

Key Words: APC; microtubule; cytoskeletons; Wnt; ß-catenin

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