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Published 29 October 2001. doi:10.1083/jcb.200110019
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© The Rockefeller University Press, 0021-9525/2001/10/327 $5.00
The Journal of Cell Biology, Volume 155, Number 3, October 29, 2001 327-330

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A Src-astic response to mounting tension



Daniel G. Jay

Department of Physiology, Tufts University School of Medicine, Boston, MA 02111

Address correspondence to Daniel G. Jay, Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111. Tel.: (617) 636-6714. Fax: (617) 636-0445. E-mail: djay01{at}emerald.tufts.edu

The nerve growth cone binds to a complex array of guidance cues in its local environment that influence cytoskeletal interactions to control the direction of subsequent axon outgrowth. How this occurs is a critical question and must certainly involve signal transduction pathways. The paper by Suter and Forscher (2001)(this issue) begins to address how one such pathway, an Src family tyrosine kinase, enhances cytoskeletal linkage to apCAM, a permissive extracellular cue for Aplysia growth cones. Interestingly, they show that applied tension increases this kinase's localized phosphorylation that in turn further strengthens linkage. This suggests a potential positive feedback mechanism for amplifying and discriminating guidance information to guide growth cone motility.


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