Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 250K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Degterev, A. Articles by Yuan, J. Search for Related Content PubMed PubMed Citation Articles by Degterev, A. Articles by Yuan, J. Social Bookmarking                            What's this?

© The Rockefeller University Press, 0021-9525/2001/11/695 $5.00
The Journal of Cell Biology, Volume 155, Number 5, November 26, 2001 695-698

The channel of death

Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115

Address correspondence to J. Yuan Department of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115. Tel.: (617) 432-4170. Fax: (617) 432-4177. E-mail: jyuan{at}hms.harvard.edu

The proapoptotic members of the Bcl-2 family have been proposed to participate in the formation of a channel that releases these apoptogenic factors when mitochondria receive apoptotic signals. A recent study provides the first direct, biophysical measurement of a potentially apoptosis-specific mitochondrial channel, which is regulated by Bcl-2 family members and may play a primary role in the release of the proapoptotic factors.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Facebook

Reddit

Technorati

Twitter

This article has been cited by other articles:

• Fantin, V. R., Leder, P. (2004). F16, a Mitochondriotoxic Compound, Triggers Apoptosis or Necrosis Depending on the Genetic Background of the Target Carcinoma Cell. Cancer Res. 64: 329-336 [Abstract] [Full Text]  
• Yang, H. H., Ma, M. H., Vescio, R. A., Berenson, J. R. (2003). Overcoming Drug Resistance in Multiple Myeloma: The Emergence of Therapeutic Approaches to Induce Apoptosis. JCO 21: 4239-4247 [Abstract] [Full Text]  
• Jonas, E. A., Hoit, D., Hickman, J. A., Brandt, T. A., Polster, B. M., Fannjiang, Y., McCarthy, E., Montanez, M. K., Hardwick, J. M., Kaczmarek, L. K. (2003). Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xL. J. Neurosci. 23: 8423-8431 [Abstract] [Full Text]  
• Valentijn, A. J., Metcalfe, A. D., Kott, J., Streuli, C. H., Gilmore, A. P. (2003). Spatial and temporal changes in Bax subcellular localization during anoikis. JCB 162: 599-612 [Abstract] [Full Text]  
• Moreau, C., Cartron, P.-F., Hunt, A., Meflah, K., Green, D. R., Evan, G., Vallette, F. M., Juin, P. (2003). Minimal BH3 Peptides Promote Cell Death by Antagonizing Anti-apoptotic Proteins. J. Biol. Chem. 278: 19426-19435 [Abstract] [Full Text]  
• Chandra, D., Liu, J.-W., Tang, D. G. (2002). Early Mitochondrial Activation and Cytochrome c Up-regulation during Apoptosis. J. Biol. Chem. 277: 50842-50854 [Abstract] [Full Text]  
• Gottlieb, E., Armour, S. M., Thompson, C. B. (2002). Mitochondrial respiratory control is lost during growth factor deprivation. Proc. Natl. Acad. Sci. USA 99: 12801-12806 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents