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Published 26 November 2001. doi:10.1083/jcb.200107040
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© The Rockefeller University Press, 0021-9525/2001/11/705 $5.00
The Journal of Cell Biology, Volume 155, Number 5, November 26, 2001 705-710

Mini-Reviews

Evolutionary perspective on innate immune recognition



Arcady Mushegian1 and Ruslan Medzhitov2

1 Stowers Institute for Medical Research, Kansas City, MO 64110
2 Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

Address correspondence to Ruslan M. Medzhitov, Yale University School of Medicine, Howard Hughes Medical Institute, 310 Cedar St., Rm. LH416, New Haven, CT 06520. Tel.: (203) 785-7541. Fax: (203) 737-1765. E-mail: ruslan.medzhitov{at}yale.edu


Abstract

Analysis of human and Drosophila genomes demonstrates an ancient origin of innate immunity and the diversity of the mechanisms of innate immune recognition.


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