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© The Rockefeller University Press, 0021-9525/2001/12/873 $5.00
The Journal of Cell Biology, Volume 155, Number 6, December 10, 2001 873-876

Constructing a Golgi complex

Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305

Address correspondence to Suzanne R. Pfeffer, Department of Biochemistry, B400, Stanford University School of Medicine, Stanford, CA 94305. Tel.: (650) 723-6169. Fax: (650) 723-6776. E-mail: pfeffer{at}cmgm.stanford.edu

In this issue, Short et al. report the discovery of a protein named Golgin-45 that is located on the surface of the middle (or medial) cisternae of the Golgi complex. Depletion of this protein disrupts the Golgi complex and leads to the return of a resident, lumenal, medial Golgi enzyme to the endoplasmic reticulum. These findings suggest that Golgin-45 serves as a linchpin for the maintenance of Golgi complex structure, and offer hints as to the mechanisms by which the polarized Golgi complex is constructed.

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