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Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115

Address correspondence to Martin E. Hemler, Dana-Farber Cancer Institute, Rm D-1430, 44 Binney St., Boston, MA 02115. Tel.: (617) 632-3410. Fax: (617) 632-2662. E-mail: martin_hemler{at}dfci.harvard.edu

Abstract
Relatively little attention has been given to the large family of abundantly expressed transmembrane proteins known as tetraspanins. Now, the importance of tetraspanins is strongly supported by emerging genetic evidence, coupled with new insights into the biochemistry and functions of tetraspanin protein complexes.

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