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© The Rockefeller University Press, 0021-9525/2002/1/13 $5.00
The Journal of Cell Biology, Volume 156, Number 1, January 7, 2002 13-16

Myelination

Steven S. Scherer

The University of Pennsylvania Medical Center, Philadelphia, PA 19104

Address correspondence to S.S. Scherer, The University of Pennsylvania Medical Center, Room 460 Stemmler Hall, 36th Street and Hamilton Walk, Philadelphia, PA 19104-6077. Tel.: (215) 573-3198. Fax: (215) 573-4454. E-mail: sscherer{at}mail.med.upenn.edu

Feltri et al. (2001)(this issue) succeed in disrupting ß1 integrin specifically in Schwann cells, and in so doing, demonstrate that it is required for normal myelination. Their results reveal that signaling by an extracellular matrix receptor plays a key role in the differentiation of myelinating Schwann cells.

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• Rambukkana, A., Kunz, S., Min, J., Campbell, K. P., Oldstone, M. B. A. (2003). Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination. Proc. Natl. Acad. Sci. USA 100: 16071-16076 [Abstract] [Full Text]  

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