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© The Rockefeller University Press, 0021-9525/2002/1/17 $5.00
The Journal of Cell Biology, Volume 156, Number 1, January 7, 2002 17-22

Micro-RNAs

Helge Grosshans and Frank J. Slack

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520

Address correspondence to F.J. Slack, Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Ave., New Haven, CT 06520-8103. Tel.: (203) 432-3492. Fax: (203) 432-6161. E-mail: frank.slack{at}yale.edu

Abstract

Two small temporally regulated RNAs (stRNAs)^* of 22 nucleotides regulate timing of gene expression during development of the nematode C. elegans. This regulation occurs at a posttranscriptional, presumably translational, level and is distinct from RNA interference (RNAi). One of the two stRNAs, let-7, as well as its target gene, lin-41, are highly conserved even in humans, suggesting a wide employment of stRNA-mediated gene regulation. Recent reports indicate that these two stRNAs are indeed likely to represent only the tip of an iceberg with hundreds or more of additional micro-RNAs (miRNAs) existing in metazoans. miRNAs might thus be previously underestimated key participants in the field of gene regulation.

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