Nfat: ubiquitous regulator of cell differentiation and adaptation

doi:10.1083/jcb.200111073

Published 4 March 2002. doi:10.1083/jcb.200111073

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© The Rockefeller University Press, 0021-9525/2002/3/771 $5.00
The Journal of Cell Biology, Volume 156, Number 5, March 4, 2002 771-774

Mini-Reviews

Nfat

: ubiquitous regulator of cell differentiation and adaptation

Valerie Horsley and Grace K. Pavlath

Department of Pharmacology, Emory University, Atlanta, GA 30322

Address correspondence to Dr. G. Pavlath, Emory University School of Medicine, Department of Pharmacology, Room 5027, O.W. Rollins Research Building, Atlanta, GA 30322. Tel.: (404) 727-3353. Fax: (404) 727-0365. E-mail: gpavlat{at}emory.edu

Abstract

The nuclear factor of activated T cells (NFAT) proteins area family of transcription factors whose activation is controlledby calcineurin, a Ca²⁺-dependent phosphatase. Originally identifiedin T cells as inducers of cytokine gene expression, NFAT proteinsplay varied roles in cells outside of the immune system. Thisreview addresses the recent data implicating NFAT in the controlof gene expression influencing the development and adaptationof numerous mammalian cell types.

Key Words: NFAT; development; adaptation; calcium signaling; cell fate

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