Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast

doi:10.1083/jcb.200201052

Published 15 April 2002. doi:10.1083/jcb.200201052

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© The Rockefeller University Press, 0021-9525/2002/4/199 $5.00
The Journal of Cell Biology, Volume 157, Number 2, April 15, 2002 199-203

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Simple centromere, complex kinetochore

: linking spindle microtubules and centromeric DNA in budding yeast

Iain M. Cheeseman, David G. Drubin and Georjana Barnes

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

Address correspondence to Georjana Barnes, Dept. of Molecular and Cell Biology, 401 Barker Hall #3202, University of California, Berkeley, CA 94720-3202. Tel.: (510) 642-5962. Fax: (510) 643-0062. E-mail: gbarnes{at}socrates.berkeley.edu

Abstract

Although the budding yeast centromere is extremely short (125bp) compared to those of other eukaryotes, the kinetochore thatassembles on this DNA displays a rich molecular complexity.Here, we describe recent advances in our understanding of kinetochorefunction in budding yeast and present a model describing theattachment that is formed between spindle microtubules and centromericDNA. This analysis may provide general principles for kinetochorefunction and regulation.

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