The glutamine commute: take the N line and transfer to the A

doi:10.1083/jcb.200201070

Published 29 April 2002. doi:10.1083/jcb.200201070

This Article

	Full Text
	Full Text (PDF, 135K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Chaudhry, F. A.
	Articles by Edwards, R. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Chaudhry, F. A.
	Articles by Edwards, R. H.


Social Bookmarking

	What's this?

© The Rockefeller University Press, 0021-9525/2002/4/349 $5.00
The Journal of Cell Biology, Volume 157, Number 3, April 29, 2002 349-355

Mini-Reviews

The glutamine commute

: take the N line and transfer to the A

Farrukh A. Chaudhry, Richard J. Reimer and Robert H. Edwards

Graduate Programs in Neuroscience, Cell Biology, and Biomedical Sciences, Departments of Neurology and Physiology, University of California at San Francisco School of Medicine, San Francisco, CA 94143

Address correspondence to R.H. Edwards, Depts. of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA 94143. Tel.: (415) 502-5687. Fax: (415) 502-5687. E-mail: edwards{at}itsa.ucsf.edu

Abstract

The transfer of glutamine between cells contributes to signalingas well as to metabolism. The recent identification and characterizationof the system N and A family of transporters has begun to suggestmechanisms for the directional transfer of glutamine, and shouldprovide ways to test its physiological significance in diverseprocesses from nitrogen to neurotransmitter release.

Key Words: glutamine; system N; system A; glutamate; glutamine–glutamate cycle

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Bryant, A. S., Li, B., Beenhakker, M. P., Huguenard, J. R. (2009). Maintenance of Thalamic Epileptiform Activity Depends on the Astrocytic Glutamate-Glutamine Cycle. J. Neurophysiol. 102: 2880-2888 [Abstract] [Full Text]
Gaisler-Salomon, I., Schobel, S. A., Small, S. A., Rayport, S. (2009). How High-Resolution Basal-State Functional Imaging Can Guide the Development of New Pharmacotherapies for Schizophrenia. Schizophr Bull 35: 1037-1044 [Abstract] [Full Text]
Shaffer, P. L., Goehring, A., Shankaranarayanan, A., Gouaux, E. (2009). Structure and Mechanism of a Na+-Independent Amino Acid Transporter. Science 325: 1010-1014 [Abstract] [Full Text]
Jenstad, M., Quazi, A. Z., Zilberter, M., Haglerod, C., Berghuis, P., Saddique, N., Goiny, M., Buntup, D., Davanger, S., S. Haug, F.-M., Barnes, C. A., McNaughton, B. L., Ottersen, O. P., Storm-Mathisen, J., Harkany, T., Chaudhry, F. A. (2009). System A Transporter SAT2 Mediates Replenishment of Dendritic Glutamate Pools Controlling Retrograde Signaling by Glutamate. Cereb Cortex 19: 1092-1106 [Abstract] [Full Text]
Grewal, S., Defamie, N., Zhang, X., De Gois, S., Shawki, A., Mackenzie, B., Chen, C., Varoqui, H., Erickson, J. D. (2009). SNAT2 Amino Acid Transporter Is Regulated by Amino Acids of the SLC6 {gamma}-Aminobutyric Acid Transporter Subfamily in Neocortical Neurons and May Play No Role in Delivering Glutamine for Glutamatergic Transmission. J. Biol. Chem. 284: 11224-11236 [Abstract] [Full Text]
Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B., Ganapathy, V. (2008). Expression and Function of System N Glutamine Transporters (SN1/SN2 or SNAT3/SNAT5) in Retinal Ganglion Cells. IOVS 49: 5151-5160 [Abstract] [Full Text]
Mano, I., Straud, S., Driscoll, M. (2007). Caenorhabditis elegans Glutamate Transporters Influence Synaptic Function and Behavior at Sites Distant from the Synapse. J. Biol. Chem. 282: 34412-34419 [Abstract] [Full Text]
Kam, K., Nicoll, R. (2007). Excitatory Synaptic Transmission Persists Independently of the Glutamate Glutamine Cycle. J. Neurosci. 27: 9192-9200 [Abstract] [Full Text]
Milatovic, D., Yin, Z., Gupta, R. C., Sidoryk, M., Albrecht, J., Aschner, J. L., Aschner, M. (2007). Manganese Induces Oxidative Impairment in Cultured Rat Astrocytes. Toxicol Sci 98: 198-205 [Abstract] [Full Text]
Liang, S.-L., Carlson, G. C., Coulter, D. A. (2006). Dynamic Regulation of Synaptic GABA Release by the Glutamate-Glutamine Cycle in Hippocampal Area CA1.. J. Neurosci. 26: 8537-8548 [Abstract] [Full Text]
Masson, J., Darmon, M., Conjard, A., Chuhma, N., Ropert, N., Thoby-Brisson, M., Foutz, A. S., Parrot, S., Miller, G. M., Jorisch, R., Polan, J., Hamon, M., Hen, R., Rayport, S. (2006). Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth.. J. Neurosci. 26: 4660-4671 [Abstract] [Full Text]
Umapathy, N. S., Li, W., Mysona, B. A., Smith, S. B., Ganapathy, V. (2005). Expression and Function of Glutamine Transporters SN1 (SNAT3) and SN2 (SNAT5) in Retinal Muller Cells. IOVS 46: 3980-3987 [Abstract] [Full Text]
Solbu, T. T., Boulland, J.-L., Zahid, W., Lyamouri Bredahl, M. K., Amiry-Moghaddam, M., Storm-Mathisen, J., Roberg, B. A., Chaudhry, F. A. (2005). Induction and Targeting of the Glutamine Transporter SN1 to the Basolateral Membranes of Cortical Kidney Tubule Cells during Chronic Metabolic Acidosis Suggest a Role in pH Regulation. J. Am. Soc. Nephrol. 16: 869-877 [Abstract] [Full Text]
Velasco, I., Tenreiro, S., Calderon, I. L., Andre, B. (2004). Saccharomyces cerevisiae Aqr1 Is an Internal-Membrane Transporter Involved in Excretion of Amino Acids. Eukaryot Cell 3: 1492-1503 [Abstract] [Full Text]
Baird, F. E., Beattie, K. J., Hyde, A. R., Ganapathy, V., Rennie, M. J., Taylor, P. M. (2004). Bidirectional substrate fluxes through the System N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver. J. Physiol. 559: 367-381 [Abstract] [Full Text]
Melone, M., Quagliano, F., Barbaresi, P., Varoqui, H., Erickson, J. D., Conti, F. (2004). Localization of the Glutamine Transporter SNAT1 in Rat Cerebral Cortex and Neighboring Structures, With a Note on its Localization in Human Cortex. Cereb Cortex 14: 562-574 [Abstract] [Full Text]
Rubio-Aliaga, I., Boll, M., Vogt Weisenhorn, D. M., Foltz, M., Kottra, G., Daniel, H. (2004). The Proton/Amino Acid Cotransporter PAT2 Is Expressed in Neurons with a Different Subcellular Localization than Its Paralog PAT1. J. Biol. Chem. 279: 2754-2760 [Abstract] [Full Text]
Wreden, C. C., Johnson, J., Tran, C., Seal, R. P., Copenhagen, D. R., Reimer, R. J., Edwards, R. H. (2003). The H+-Coupled Electrogenic Lysosomal Amino Acid Transporter LYAAT1 Localizes to the Axon and Plasma Membrane of Hippocampal Neurons. J. Neurosci. 23: 1265-1275 [Abstract] [Full Text]