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Epitomics: The Rabbit Monoclonal Company
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Published 29 April 2002. doi:10.1083/jcb.200201070
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© The Rockefeller University Press, 0021-9525/2002/4/349 $5.00
The Journal of Cell Biology, Volume 157, Number 3, April 29, 2002 349-355

Mini-Reviews

 The glutamine commute : take the N line and transfer to the A



Farrukh A. Chaudhry, Richard J. Reimer and Robert H. Edwards

Graduate Programs in Neuroscience, Cell Biology, and Biomedical Sciences, Departments of Neurology and Physiology, University of California at San Francisco School of Medicine, San Francisco, CA 94143

Address correspondence to R.H. Edwards, Depts. of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA 94143. Tel.: (415) 502-5687. Fax: (415) 502-5687. E-mail: edwards{at}itsa.ucsf.edu


Abstract
The transfer of glutamine between cells contributes to signaling as well as to metabolism. The recent identification and characterization of the system N and A family of transporters has begun to suggest mechanisms for the directional transfer of glutamine, and should provide ways to test its physiological significance in diverse processes from nitrogen to neurotransmitter release.

Key Words: glutamine; system N; system A; glutamate; glutamine–glutamate cycle


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