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© The Rockefeller University Press, 0021-9525/2002/5/557 $5.00
The Journal of Cell Biology, Volume 157, Number 4, May 13, 2002 557-563

Secretory traffic in the eukaryotic parasite Toxoplasma gondii

Keith A. Joiner¹ and David S. Roos²

¹ Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520
² Department of Biology, University of Pennsylvania, Philadelphia, PA 19104

Address correspondence to Keith Joiner, Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520-8022. Tel.: (203) 785-2115. Fax: (203) 785-3864. E-mail: keith.joiner{at}yale.edu

Abstract

Name a single-celled eukaryote that boasts a small genome size, is easily cultivated in haploid form, for which a wide variety of molecular genetic tools are available, and that exhibits a simple, polarized secretory apparatus with a well-defined endoplasmic reticulum and Golgi that can serve as a model for understanding secretion. Got it? Now name a cell with all these attributes that contains at least a dozen distinct and morphologically well-defined intracellular organelles, including three distinct types of secretory vesicles and two endosymbiotic organelles. Not so sure anymore?

Key Words: secretory pathway; vesicular trafficking; protozoan cell biology; Apicomplexan parasites; eukaryotic evolution

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