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© The Rockefeller University Press, 0021-9525/2002/5/739 $5.00
The Journal of Cell Biology, Volume 157, Number 5, May 28, 2002 739-741

Building an efficient factory

Sui Huang

Department of Cell and Molecular Biology, Northwestern University Medical School

Address correspondence to S. Huang, Department of Cell and Molecular Biology, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, IL 60611. Tel.: (312) 503-4269. Fax: (312) 503-7912. E-mail: s-huang2{at}northwestern.edu

The subnucleolar structure that is involved in rDNA transcription has been controversial. A report by Koberna et al. (2002)(this issue, page 743) adds significant weight toward the idea that dense fibrillar components (DFCs)^* and fibrillar center (FC)/DFC borders are the sites of pre-rRNA synthesis.

Key Words: nucleolus; sites of DNA transcription; Christmas tree; Br-U labeling; dense fibrillar components

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Ribosomal genes in focus: new transcripts label the dense fibrillar components and form clusters indicative of "Christmas trees" in situ

Karel Koberna, Jan Malínsky, Artem Pliss, Martin Masata, Jaromíra Vecerová, Markéta Fialová, Jan Bednár, and Ivan Raska
J. Cell Biol. 2002 157: 743-748. [Abstract] [Full Text] [PDF]

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