Proximal location of mouse prostate epithelial stem cells: a model of prostatic homeostasis

doi:10.1083/jcb.200202067

Published 24 June 2002. doi:10.1083/jcb.200202067

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© The Rockefeller University Press, 0021-9525/2002/6/1257 $5.00
The Journal of Cell Biology, Volume 157, Number 7, June 24, 2002 1257-1265

Article

Proximal location of mouse prostate epithelial stem cells

: a model of prostatic homeostasis

Akira Tsujimura¹^,5, Yasuhiro Koikawa¹^,6, Sarah Salm¹, Tetsuya Takao¹^,5, Sandra Coetzee¹, David Moscatelli¹^,4, Ellen Shapiro²^,4, Herbert Lepor²^,4, Tung-Tien Sun²^,3^,4 and E. Lynette Wilson¹^,2^,4

¹ Department of Cell Biology, New York University School of Medicine, New York, NY 10016
² Department of Urology, New York University School of Medicine, New York, NY 10016
³ Ronald O. Perelman Department of Dermatology and Department of Pharmacology, New York University School of Medicine, New York, NY 10016
⁴ Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016
⁵ Department of Urology, Osaka University Medical School, Suita, Osaka 565-0871, Japan
⁶ Department of Urology, Fukuoka City Medical Center of Sick Children and Infectious Diseases, Fukuoka 810-0063, Japan

Address correspondence to E. Lynette Wilson, Department of Cell Biology, New York University School of Medicine, 550 First Ave., New York, NY 10016. Tel.: (212) 263-7684. Fax: (212) 263-8139. E-mail: wilsoe01{at}endeavor.med.nyu.edu

Stem cells are believed to regulate normal prostatic homeostasisand to play a role in the etiology of prostate cancer and benignprostatic hyperplasia. We show here that the proximal regionof mouse prostatic ducts is enriched in a subpopulation of epithelialcells that exhibit three important attributes of epithelialstem cells: they are slow cycling, possess a high in vitro proliferativepotential, and can reconstitute highly branched glandular ductalstructures in collagen gels. We propose a model of prostatichomeostasis in which mouse prostatic epithelial stem cells areconcentrated in the proximal region of prostatic ducts whilethe transit-amplifying cells occupy the distal region of theducts. This model can account for many biological differencesbetween cells of the proximal and distal regions, and has implicationsfor prostatic disease formation.

Key Words: prostate; stem cells; slow-cycling cells; branching morphogenesis; prostate regeneration

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