JCB logo
MBoC5 from Garland Science
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 24 June 2002. doi:10.1083/jcb.200202067
This Article
Right arrow Full Text
Right arrow PDF (Full Text)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsujimura, A.
Right arrow Articles by Wilson, E. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsujimura, A.
Right arrow Articles by Wilson, E. L.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Stem Cells
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
© The Rockefeller University Press, 0021-9525/2002/6/1257 $5.00
The Journal of Cell Biology, Volume 157, Number 7, June 24, 2002 1257-1265

Article

 Proximal location of mouse prostate epithelial stem cells : a model of prostatic homeostasis



Akira Tsujimura1,5, Yasuhiro Koikawa1,6, Sarah Salm1, Tetsuya Takao1,5, Sandra Coetzee1, David Moscatelli1,4, Ellen Shapiro2,4, Herbert Lepor2,4, Tung-Tien Sun2,3,4 and E. Lynette Wilson1,2,4

1 Department of Cell Biology, New York University School of Medicine, New York, NY 10016
2 Department of Urology, New York University School of Medicine, New York, NY 10016
3 Ronald O. Perelman Department of Dermatology and Department of Pharmacology, New York University School of Medicine, New York, NY 10016
4 Kaplan Cancer Center, New York University School of Medicine, New York, NY 10016
5 Department of Urology, Osaka University Medical School, Suita, Osaka 565-0871, Japan
6 Department of Urology, Fukuoka City Medical Center of Sick Children and Infectious Diseases, Fukuoka 810-0063, Japan

Address correspondence to E. Lynette Wilson, Department of Cell Biology, New York University School of Medicine, 550 First Ave., New York, NY 10016. Tel.: (212) 263-7684. Fax: (212) 263-8139. E-mail: wilsoe01{at}endeavor.med.nyu.edu

Stem cells are believed to regulate normal prostatic homeostasis and to play a role in the etiology of prostate cancer and benign prostatic hyperplasia. We show here that the proximal region of mouse prostatic ducts is enriched in a subpopulation of epithelial cells that exhibit three important attributes of epithelial stem cells: they are slow cycling, possess a high in vitro proliferative potential, and can reconstitute highly branched glandular ductal structures in collagen gels. We propose a model of prostatic homeostasis in which mouse prostatic epithelial stem cells are concentrated in the proximal region of prostatic ducts while the transit-amplifying cells occupy the distal region of the ducts. This model can account for many biological differences between cells of the proximal and distal regions, and has implications for prostatic disease formation.

Key Words: prostate; stem cells; slow-cycling cells; branching morphogenesis; prostate regeneration


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

Prostate stem cells identified
Nicole LeBrasseur
J. Cell Biol. 2002 157: 1100. [Full Text] [PDF]





  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents