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Published 22 July 2002. doi:10.1083/jcb.200206094
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© The Rockefeller University Press, 0021-9525/2002/7/197 $5.00
The Journal of Cell Biology, Volume 158, Number 2, July 22, 2002 197-199

Comment

Lysophospholipids in the limelight

: autotaxin takes center stage



Wouter H. Moolenaar

Division of Cellular Biochemistry and Centre for Biomedical Genetics, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands

Address correspondence to Wouter H. Moolenaar, Division of Cellular Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands. Tel.: 31-20-512-1971. Fax: 31-20-512-1989. E-mail: w.moolenaar{at}nki.nl

Lysophosphatidic acid (LPA) is a serum phospholipid that evokes growth factor–like responses in many cell types through the activation of its G protein–coupled receptors. Although much is known about LPA signaling, it has remained unclear where and how bioactive LPA is produced. Umezu-Goto et al. (2002)(this issue, page 227) have purified a serum lysophospholipase D that generates LPA from lysophosphatidylcholine and found it to be identical to autotaxin, a cell motility–stimulating ectophosphodiesterase implicated in tumor progression. This result is surprising, as there was previously no indication that autotaxin could act as a phospholipase.


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