JCB logo
amgmicro.com
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

Published 22 July 2002. doi:10.1083/jcb.200203006
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 591K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bourdon, J.-C.
Right arrow Articles by Lane, D.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bourdon, J.-C.
Right arrow Articles by Lane, D.P.
Related Collections
Right arrowRelated Article
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

© The Rockefeller University Press, 0021-9525/2002/7/235 $5.00
The Journal of Cell Biology, Volume 158, Number 2, July 22, 2002 235-246


Article

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane



J.-C. Bourdon, J. Renzing, P.L. Robertson, K.N. Fernandes and D.P. Lane

Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Cancer Research Campaign (CRC) Cell Transformation Research Group, University of Dundee, Dundee DD1 9SY, UK

Address correspondence to D.P. Lane, Dept. of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, CRC Cell Transformation Research Group, University of Dundee, Dundee DD1 9SY, UK. Tel.: 44-1382-496362. Fax: 44-1382-496363. E-mail: j.bourdon{at}dundee.ac.uk

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after {gamma}-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis.

Key Words: transactivation; p53-binding site; cell death; cancer; 3p21


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related Article

Signaling from strange places
Alan W. Dove
J. Cell Biol. 2002 158: 193. [Full Text] [PDF]



This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents