Published online 29 July 2002. doi:10.1083/jcb.200205110
© The Rockefeller University Press,
0021-9525/2002/8/389 $5.00
The Journal of Cell Biology, Volume 158, Number 3, August 5, 2002 389-394
Lysosomes and the plasma membrane
:
trypanosomes reveal a secret relationship
Norma W. Andrews
Section of Microbial Pathogenesis and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06536
Address correspondence to Norma W. Andrews, Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Ave., New Haven, CT 06536. Tel.: (203) 737-2410. Fax: (203) 737-2630. E-mail: norma.andrews{at}yale.edu
Abstract
Studies of the cell invasion mechanism of the parasite Trypanosoma cruzi led to a series of novel findings, which revealed a previously unsuspected ability of conventional lysosomes to fuse with the plasma membrane. This regulated exocytic process, previously regarded mostly as a specialization of certain cell types, was recently shown to play an important role in the mechanism by which cells reseal their plasma membrane after injury.
Key Words: lysosome; Trypanosome cruzi; exocytosis; secretion
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