Hijacking the translation apparatus by RNA viruses

doi:10.1083/jcb.200205044

Published 5 August 2002. doi:10.1083/jcb.200205044

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© The Rockefeller University Press, 0021-9525/2002/8/395 $5.00
The Journal of Cell Biology, Volume 158, Number 3, August 5, 2002 395-399

Mini-Reviews

Hijacking the translation apparatus by RNA viruses

Martin Bushell and Peter Sarnow

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305

Address correspondence to Peter Sarnow, Dept. of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305. Tel.: (650) 498-7076. Fax: (650) 498-7147. E-mail: psarnow{at}stanford.edu

Abstract

As invading viruses do not harbor functional ribosomes in theirvirions, successful amplification of the viral genomes requiresthat viral mRNAs compete with cellular mRNAs for the host celltranslation apparatus. Several RNA viruses have evolved remarkablestrategies to recruit the host translation initiation factorsrequired for the first steps in translation initiation by hostcell mRNAs. This review describes the ways that three familiesof RNA viruses effectively usurp limiting translation initiationfactors from the host.

Key Words: translation; picornavirus; rotavirus; cricket paralysis–like virus; start codon selection

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