Yersinia type III secretion: send in the effectors

doi:10.1083/jcb.200205077

Published 5 August 2002. doi:10.1083/jcb.200205077

This Article

	Full Text
	Full Text (PDF, 412K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Cornelis, G. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Cornelis, G. R.

Social Bookmarking

	What's this?

© The Rockefeller University Press, 0021-9525/2002/8/401 $5.00
The Journal of Cell Biology, Volume 158, Number 3, August 5, 2002 401-408

Mini-Reviews

Yersinia type III secretion

: send in the effectors

Guy R. Cornelis¹^,2

¹ Biozentrum der Universität Basel, CH-4056 Basel, Switzerland
² Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B 1200 Brussels, Belgium

Address correspondence to Guy R. Cornelis, Biozentrum der Universität Basel, Klingelbergstr. 50-70, CH-4056 Basel, Switzerland. Tel.: 41-61-267-21-10. Fax: 41-61-267-21-18. E-mail: guy.cornelis{at}unibas.ch

Abstract

Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis,and Yersinia enterocolitica) have evolved an exquisite methodfor delivering powerful effectors into cells of the host immunesystem where they inhibit signaling cascades and block the cells'response to infection. Understanding the molecular mechanismsof this system has provided insight into the processes of phagocytosisand inflammation.

Key Words: bacterial pathogenesis; Yersinia; Yops; translocation; type III secretion

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Bergsbaken, T., Cookson, B. T. (2009). Innate immune response during Yersinia infection: critical modulation of cell death mechanisms through phagocyte activation. J. Leukoc. Biol. 86: 1153-1158 [Abstract] [Full Text]
Pandey, A. K., Sodhi, A. (2009). Recombinant YopJ induces apoptosis in murine peritoneal macrophages in vitro: involvement of mitochondrial death pathway. Int Immunol 21: 1239-1249 [Abstract] [Full Text]
Noel, B. L., Lilo, S., Capurso, D., Hill, J., Bliska, J. B. (2009). Yersinia pestis Can Bypass Protective Antibodies to LcrV and Activation with Gamma Interferon To Survive and Induce Apoptosis in Murine Macrophages. CVI 16: 1457-1466 [Abstract] [Full Text]
Corcionivoschi, N., Clyne, M., Lyons, A., Elmi, A., Gundogdu, O., Wren, B. W., Dorrell, N., Karlyshev, A. V., Bourke, B. (2009). Campylobacter jejuni Cocultured with Epithelial Cells Reduces Surface Capsular Polysaccharide Expression. Infect. Immun. 77: 1959-1967 [Abstract] [Full Text]
Matsumoto, H., Young, G. M. (2009). Essential Role of the SycP Chaperone in Type III Secretion of the YspP Effector. J. Bacteriol. 191: 1703-1715 [Abstract] [Full Text]
Pieper, R., Huang, S.-T., Robinson, J. M., Clark, D. J., Alami, H., Parmar, P. P., Perry, R. D., Fleischmann, R. D., Peterson, S. N. (2009). Temperature and growth phase influence the outer-membrane proteome and the expression of a type VI secretion system in Yersinia pestis. Microbiology 155: 498-512 [Abstract] [Full Text]
Anisimov, A. P., Bakhteeva, I. V., Panfertsev, E. A., Svetoch, T. E., Kravchenko, T. B., Platonov, M. E., Titareva, G. M., Kombarova, T. I., Ivanov, S. A., Rakin, A. V., Amoako, K. K., Dentovskaya, S. V. (2009). The subcutaneous inoculation of pH 6 antigen mutants of Yersinia pestis does not affect virulence and immune response in mice. J Med Microbiol 58: 26-36 [Abstract] [Full Text]
Lilo, S., Zheng, Y., Bliska, J. B. (2008). Caspase-1 Activation in Macrophages Infected with Yersinia pestis KIM Requires the Type III Secretion System Effector YopJ. Infect. Immun. 76: 3911-3923 [Abstract] [Full Text]
Li, B., Yang, R. (2008). Interaction between Yersinia pestis and the Host Immune System. Infect. Immun. 76: 1804-1811 [Full Text]
Zhang, P., Skurnik, M., Zhang, S.-S., Schwartz, O., Kalyanasundaram, R., Bulgheresi, S., He, J. J., Klena, J. D., Hinnebusch, B. J., Chen, T. (2008). Human Dendritic Cell-Specific Intercellular Adhesion Molecule-Grabbing Nonintegrin (CD209) Is a Receptor for Yersinia pestis That Promotes Phagocytosis by Dendritic Cells. Infect. Immun. 76: 2070-2079 [Abstract] [Full Text]
Lee, B. C., Lee, J. H., Kim, M. W., Kim, B. S., Oh, M. H., Kim, K.-S., Kim, T. S., Choi, S. H. (2008). Vibrio vulnificus rtxE Is Important for Virulence, and Its Expression Is Induced by Exposure to Host Cells. Infect. Immun. 76: 1509-1517 [Abstract] [Full Text]
Forman, S., Wulff, C. R., Myers-Morales, T., Cowan, C., Perry, R. D., Straley, S. C. (2008). yadBC of Yersinia pestis, a New Virulence Determinant for Bubonic Plague. Infect. Immun. 76: 578-587 [Abstract] [Full Text]
Perez-Gutierrez, C., Llompart, C. M., Skurnik, M., Bengoechea, J. A. (2007). Expression of the Yersinia enterocolitica pYV-Encoded Type III Secretion System Is Modulated by Lipopolysaccharide O-Antigen Status. Infect. Immun. 75: 1512-1516 [Abstract] [Full Text]
Bubeck, S. S., Cantwell, A. M., Dube, P. H. (2007). Delayed Inflammatory Response to Primary Pneumonic Plague Occurs in Both Outbred and Inbred Mice. Infect. Immun. 75: 697-705 [Abstract] [Full Text]
Pruijssers, A. J., Strand, M. R. (2007). PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus Localize to Focal Adhesions and Are Antiphagocytic in Insect Immune Cells. J. Virol. 81: 1209-1219 [Abstract] [Full Text]
Anisimov, A. P., Amoako, K. K. (2006). Treatment of plague: promising alternatives to antibiotics.. J Med Microbiol 55: 1461-1475 [Abstract] [Full Text]
Sorg, J. A., Blaylock, B., Schneewind, O. (2006). Secretion signal recognition by YscN, the Yersinia type III secretion ATPase. Proc. Natl. Acad. Sci. USA 103: 16490-16495 [Abstract] [Full Text]
Lemaitre, N., Sebbane, F., Long, D., Joseph Hinnebusch, B. (2006). Yersinia pestis YopJ Suppresses Tumor Necrosis Factor Alpha Induction and Contributes to Apoptosis of Immune Cells in the Lymph Node but Is Not Required for Virulence in a Rat Model of Bubonic Plague. Infect. Immun. 74: 5126-5131 [Abstract] [Full Text]
DeBord, K. L., Anderson, D. M., Marketon, M. M., Overheim, K. A., DePaolo, R. W., Ciletti, N. A., Jabri, B., Schneewind, O. (2006). Immunogenicity and Protective Immunity against Bubonic Plague and Pneumonic Plague by Immunization of Mice with the Recombinant V10 Antigen, a Variant of LcrV.. Infect. Immun. 74: 4910-4914 [Abstract] [Full Text]
Stirling, F. R., Evans, T. J. (2006). Effects of the type III secreted pseudomonal toxin ExoS in the yeast Saccharomyces cerevisiae.. Microbiology 152: 2273-2285 [Abstract] [Full Text]
Buhler, O. T., Wiedig, C. A., Schmid, Y., Grassl, G. A., Bohn, E., Autenrieth, I. B. (2006). The Yersinia enterocolitica Invasin Protein Promotes Major Histocompatibility Complex Class I- and Class II-Restricted T-Cell Responses. Infect. Immun. 74: 4322-4329 [Abstract] [Full Text]
Meyer, D., Cunnac, S., Gueneron, M., Declercq, C., Van Gijsegem, F., Lauber, E., Boucher, C., Arlat, M. (2006). PopF1 and PopF2, Two Proteins Secreted by the Type III Protein Secretion System of Ralstonia solanacearum, Are Translocators Belonging to the HrpF/NopX Family. J. Bacteriol. 188: 4903-4917 [Abstract] [Full Text]
Yao, Y., Xie, Y., Kim, K. S. (2006). Genomic Comparison of Escherichia coli K1 Strains Isolated from the Cerebrospinal Fluid of Patients with Meningitis. Infect. Immun. 74: 2196-2206 [Abstract] [Full Text]
Jandu, N., Ceponis, P. J. M., Kato, S., Riff, J. D., McKay, D. M., Sherman, P. M. (2006). Conditioned Medium from Enterohemorrhagic Escherichia coli-Infected T84 Cells Inhibits Signal Transducer and Activator of Transcription 1 Activation by Gamma Interferon. Infect. Immun. 74: 1809-1818 [Abstract] [Full Text]
Chromy, B. A., Choi, M. W., Murphy, G. A., Gonzales, A. D., Corzett, C. H., Chang, B. C., Fitch, J. P., McCutchen-Maloney, S. L. (2005). Proteomic Characterization of Yersinia pestis Virulence. J. Bacteriol. 187: 8172-8180 [Abstract] [Full Text]
Sorg, J. A., Miller, N. C., Marketon, M. M., Schneewind, O. (2005). Rejection of Impassable Substrates by Yersinia Type III Secretion Machines. J. Bacteriol. 187: 7090-7102 [Abstract] [Full Text]
Marketon, M. M., DePaolo, R. W., DeBord, K. L., Jabri, B., Schneewind, O. (2005). Plague Bacteria Target Immune Cells During Infection. Science 309: 1739-1741 [Abstract] [Full Text]
Cowan, C., Philipovskiy, A. V., Wulff-Strobel, C. R., Ye, Z., Straley, S. C. (2005). Anti-LcrV Antibody Inhibits Delivery of Yops by Yersinia pestis KIM5 by Directly Promoting Phagocytosis. Infect. Immun. 73: 6127-6137 [Abstract] [Full Text]
Brubaker, R. R. (2005). Influence of Na+, Dicarboxylic Amino Acids, and pH in Modulating the Low-Calcium Response of Yersinia pestis. Infect. Immun. 73: 4743-4752 [Abstract] [Full Text]
Deng, W., Li, Y., Hardwidge, P. R., Frey, E. A., Pfuetzner, R. A., Lee, S., Gruenheid, S., Strynakda, N. C. J., Puente, J. L., Finlay, B. B. (2005). Regulation of Type III Secretion Hierarchy of Translocators and Effectors in Attaching and Effacing Bacterial Pathogens. Infect. Immun. 73: 2135-2146 [Abstract] [Full Text]
Ryndak, M. B., Chung, H., London, E., Bliska, J. B. (2005). Role of Predicted Transmembrane Domains for Type III Translocation, Pore Formation, and Signaling by the Yersinia pseudotuberculosis YopB Protein. Infect. Immun. 73: 2433-2443 [Abstract] [Full Text]
Philipovskiy, A. V., Cowan, C., Wulff-Strobel, C. R., Burnett, S. H., Kerschen, E. J., Cohen, D. A., Kaplan, A. M., Straley, S. C. (2005). Antibody against V Antigen Prevents Yop-Dependent Growth of Yersinia pestis. Infect. Immun. 73: 1532-1542 [Abstract] [Full Text]
Petnicki-Ocwieja, T., van Dijk, K., Alfano, J. R. (2005). The hrpK Operon of Pseudomonas syringae pv. tomato DC3000 Encodes Two Proteins Secreted by the Type III (Hrp) Protein Secretion System: HopB1 and HrpK, a Putative Type III Translocator. J. Bacteriol. 187: 649-663 [Abstract] [Full Text]
Ramamurthi, K. S., Schneewind, O. (2005). A Synonymous Mutation in Yersinia enterocolitica yopE Affects the Function of the YopE Type III Secretion Signal. J. Bacteriol. 187: 707-715 [Abstract] [Full Text]
Saikh, K. U., Kissner, T. L., Sultana, A., Ruthel, G., Ulrich, R. G. (2004). Human Monocytes Infected with Yersinia pestis Express Cell Surface TLR9 and Differentiate into Dendritic Cells. J. Immunol. 173: 7426-7434 [Abstract] [Full Text]
Trosky, J. E., Mukherjee, S., Burdette, D. L., Roberts, M., McCarter, L., Siegel, R. M., Orth, K. (2004). Inhibition of MAPK Signaling Pathways by VopA from Vibrio parahaemolyticus. J. Biol. Chem. 279: 51953-51957 [Abstract] [Full Text]
Ghosh, P. (2004). Process of Protein Transport by the Type III Secretion System. Microbiol. Mol. Biol. Rev. 68: 771-795 [Abstract] [Full Text]
Schmid, Y., Grassl, G. A., Buhler, O. T., Skurnik, M., Autenrieth, I. B., Bohn, E. (2004). Yersinia enterocolitica Adhesin A Induces Production of Interleukin-8 in Epithelial Cells. Infect. Immun. 72: 6780-6789 [Abstract] [Full Text]
Erfurth, S. E., Grobner, S., Kramer, U., Gunst, D. S. J., Soldanova, I., Schaller, M., Autenrieth, I. B., Borgmann, S. (2004). Yersinia enterocolitica Induces Apoptosis and Inhibits Surface Molecule Expression and Cytokine Production in Murine Dendritic Cells. Infect. Immun. 72: 7045-7054 [Abstract] [Full Text]
Maresso, A. W., Baldwin, M. R., Barbieri, J. T. (2004). Ezrin/Radixin/Moesin Proteins Are High Affinity Targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS. J. Biol. Chem. 279: 38402-38408 [Abstract] [Full Text]
Swietnicki, W., O'Brien, S., Holman, K., Cherry, S., Brueggemann, E., Tropea, J. E., Hines, H. B., Waugh, D. S., Ulrich, R. G. (2004). Novel Protein-Protein Interactions of the Yersinia pestis Type III Secretion System Elucidated with a Matrix Analysis by Surface Plasmon Resonance and Mass Spectrometry. J. Biol. Chem. 279: 38693-38700 [Abstract] [Full Text]
Kerschen, E. J., Cohen, D. A., Kaplan, A. M., Straley, S. C. (2004). The Plague Virulence Protein YopM Targets the Innate Immune Response by Causing a Global Depletion of NK Cells. Infect. Immun. 72: 4589-4602 [Abstract] [Full Text]
Kapatral, V., Campbell, J. W., Minnich, S. A., Thomson, N. R., Matsumura, P., Pruss, B. M. (2004). Gene array analysis of Yersinia enterocolitica FlhD and FlhC: regulation of enzymes affecting synthesis and degradation of carbamoylphosphate. Microbiology 150: 2289-2300 [Abstract] [Full Text]
Deng, W., Puente, J. L., Gruenheid, S., Li, Y., Vallance, B. A., Vazquez, A., Barba, J., Ibarra, J. A., O'Donnell, P., Metalnikov, P., Ashman, K., Lee, S., Goode, D., Pawson, T., Finlay, B. B. (2004). Dissecting virulence: Systematic and functional analyses of a pathogenicity island. Proc. Natl. Acad. Sci. USA 101: 3597-3602 [Abstract] [Full Text]
Handley, S. A., Dube, P. H., Revell, P. A., Miller, V. L. (2004). Characterization of Oral Yersinia enterocolitica Infection in Three Different Strains of Inbred Mice. Infect. Immun. 72: 1645-1656 [Abstract] [Full Text]
Cambronne, E. D., Sorg, J. A., Schneewind, O. (2004). Binding of SycH Chaperone to YscM1 and YscM2 Activates Effector yop Expression in Yersinia enterocolitica. J. Bacteriol. 186: 829-841 [Abstract] [Full Text]
Jacobi, C. A., Bach, A., Eberl, L., Steidle, A., Heesemann, J. (2003). Detection of N-(3-Oxohexanoyl)-L-Homoserine Lactone in Mice Infected with Yersinia enterocolitica Serotype O8. Infect. Immun. 71: 6624-6626 [Abstract] [Full Text]
Strauch, E., Goelz, G., Knabner, D., Konietzny, A., Lanka, E., Appel, B. (2003). A cryptic plasmid of Yersinia enterocolitica encodes a conjugative transfer system related to the regions of CloDF13 Mob and IncX Pil. Microbiology 149: 2829-2845 [Abstract] [Full Text]
Brubaker, R. R. (2003). Interleukin-10 and Inhibition of Innate Immunity to Yersiniae: Roles of Yops and LcrV (V Antigen). Infect. Immun. 71: 3673-3681 [Full Text]
Zusman, T., Yerushalmi, G., Segal, G. (2003). Functional Similarities between the icm/dot Pathogenesis Systems of Coxiella burnetii and Legionella pneumophila. Infect. Immun. 71: 3714-3723 [Abstract] [Full Text]
DeBord, K. L., Galanopoulos, N. S., Schneewind, O. (2003). The ttsA Gene Is Required for Low-Calcium-Induced Type III Secretion of Yop Proteins and Virulence of Yersinia enterocolitica W22703. J. Bacteriol. 185: 3499-3507 [Abstract] [Full Text]
DeMali, K. A., Burridge, K. (2003). Coupling membrane protrusion and cell adhesion. J. Cell Sci. 116: 2389-2397 [Abstract] [Full Text]
Shao, F., Vacratsis, P. O., Bao, Z., Bowers, K. E., Fierke, C. A., Dixon, J. E. (2003). Biochemical characterization of the Yersinia YopT protease: Cleavage site and recognition elements in Rho GTPases. Proc. Natl. Acad. Sci. USA 100: 904-909 [Abstract] [Full Text]
Yoon, S., Liu, Z., Eyobo, Y., Orth, K. (2003). Yersinia Effector YopJ Inhibits Yeast MAPK Signaling Pathways by an Evolutionarily Conserved Mechanism. J. Biol. Chem. 278: 2131-2135 [Abstract] [Full Text]
Galan, J. E. (2002). The cell biology of microbial infections: coming of age. JCB 158: 387-388 [Full Text]