JCB logo
R&D Systems
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 5 August 2002. doi:10.1083/jcb.200205009
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 183K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Portnoy, D. A.
Right arrow Articles by Glomski, I. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Portnoy, D. A.
Right arrow Articles by Glomski, I. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
© The Rockefeller University Press, 0021-9525/2002/8/409 $5.00
The Journal of Cell Biology, Volume 158, Number 3, August 5, 2002 409-414

Mini-Reviews

 The cell biology of Listeria monocytogenes infection : the intersection of bacterial pathogenesis and cell-mediated immunity



Daniel A. Portnoy1,2, Victoria Auerbuch1 and Ian J. Glomski1

1 Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720
2 The School of Public Health, University of California, Berkeley, CA 94720

Address correspondence to Daniel A. Portnoy, Dept. of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94703-3200. Tel.: (510) 643-3925. Fax: (510) 643-6791. E-mail: portnoy{at}uclink4.berkeley.edu


Abstract
Listeria monocytogenes has emerged as a remarkably tractable pathogen to dissect basic aspects of cell biology, intracellular pathogenesis, and innate and acquired immunity. In order to maintain its intracellular lifestyle, L. monocytogenes has evolved a number of mechanisms to exploit host processes to grow and spread cell to cell without damaging the host cell. The pore-forming protein listeriolysin O mediates escape from host vacuoles and utilizes multiple fail-safe mechanisms to avoid causing toxicity to infected cells. Once in the cytosol, the L. monocytogenes ActA protein recruits host cell Arp2/3 complexes and enabled/vasodilator-stimulated phosphoprotein family members to mediate efficient actin-based motility, thereby propelling the bacteria into neighboring cells. Alteration in any of these processes dramatically reduces the ability of the bacteria to establish a productive infection in vivo.

Key Words: hemolysins; phagosome; virulence; macrophage; actins


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents