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Craig R. Roy¹ and Lewis G. Tilney²

¹ Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536
² Department of Biology, University of Pennsylvania, Philadelphia, PA 19104

Address correspondence to Craig R. Roy, Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave., New Haven, CT 06536. Tel.: (203) 737-2408. Fax: (203) 737-2630. E-mail: craig.roy{at}yale.edu

Abstract
Phagosomes containing the bacterial pathogen Legionella pneumophila are transported to the ER after macrophage internalization. To modulate phagosome transport, Legionella use a specialized secretion system that injects bacterial proteins into eukaryotic cells. This review will focus on recent studies that have identified bacterial proteins and host processes that play a concerted role in transporting Legionella to the ER.

Key Words: phagosome lysosome fusion; ADP ribosylation factor; type IV secretion; immune evasion; intracellular replication

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