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© The Rockefeller University Press, 0021-9525/2002/8/421 $5.00
The Journal of Cell Biology, Volume 158, Number 3, August 5, 2002 421-426

Mycobacterium and the coat of many lipids

¹ Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
² Wellcome Research Laboratories, Chichiri, Blantyre 3, Malawi

Address correspondence to David G. Russell, Cornell University/College of Veterinary Medicine, Dept. of Microbiology and Immunology, 5 173 Vet Medical Center, Ithaca, NY 14853. Tel.: (607) 253-3401. Fax: (607) 253-4058. E-mail: dgr8{at}cornell.edu

Abstract

Pathogenic Mycobacterium reside inside vacuoles in their host macrophages. These vacuoles fail to fuse with lysosomes yet interact with early endosomes. Glycoconjugates released by the intracellular bacilli traffic through the host cell and are released through exocytosis. These molecules represent both antigens for immune recognition and modulators of immune function. The molecules play key roles in the induction and maintenance of the granuloma, a tissue response that limits bacterial spread yet ensures persistence of the infection.

Key Words: mycobacterium; macrophage; phagosome; tuberculosis; lipidoglycan

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