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© The Rockefeller University Press, 0021-9525/2002/8/615 $5.00
The Journal of Cell Biology, Volume 158, Number 4, August 19, 2002 615-616

Sweet solution

Hudson H. Freeze

The Burnham Institute, La Jolla Cancer Research Center, La Jolla, CA 92037

Address correspondence to Hudson H. Freeze, The Burnham Institute, La Jolla Cancer Research Center, 10901 N. Torrey Pines Rd., La Jolla, CA 92037. Tel.: (858) 646-3142. Fax: (858) 713-6281. E-mail: hudson{at}burnham.org

Sugar pills are usually placebos, but Smith et al. (2002, this issue) use one to rescue designer mice unable to make GDP-Fucose. Dietary fucose enters a salvage pathway and spares the mice. Sound simple? Not so. Unknown genetic factors determine life or death.

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