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Published 14 October 2002. doi:10.1083/jcb.200206068
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© The Rockefeller University Press, 0021-9525/2002/10/29 $5.00
The Journal of Cell Biology, Volume 159, Number 1, 29-35

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Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury



Caroline Pot1, Marjo Simonen1, Oliver Weinmann1, Lisa Schnell1, Franziska Christ1, Sascha Stoeckle1, Philipp Berger2, Thomas Rülicke3, Ueli Suter2 and Martin E. Schwab1

1 Brain Research Institute, University of Zurich, and Department of Biology, Swiss Federal Institute of Technology Zurich, CH-8057 Zurich, Switzerland
2 Institute of Cell Biology, Swiss Federal Institute of Technology Zurich, CH-8093 Zurich, Switzerland
3 Institute for Laboratory Animal Sciences, University of Zurich, CH-8091 Zurich, Switzerland

Address correspondence to Caroline Pot, Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. Tel.: 41-79-520-8000. Fax: 41-1-635-3303. E-mail: caroline.pot{at}access.unizh.ch

Înjured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in peripheral nerve Schwann cells, we show that axonal regeneration and functional recovery are impaired after a sciatic nerve crush. Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration.

Key Words: Nogo-A; growth-inhibitory protein; regeneration; peripheral nervous system; axonal repair


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