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A correction to this article has been published: J. Cell Biol. 160 (3) 451
Published 11 November 2002. doi:10.1083/jcb.200210024
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© The Rockefeller University Press, 0021-9525/2002/11/393 $5.00
The Journal of Cell Biology, Volume 159, Number 3, 393-395

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Unchain my heart, baby let me go—the entry and intracellular transport of HIV



Beate Sodeik

Department of Virology, Hannover Medical School, D-30623 Hannover, Germany

Address correspondence to Beate Sodeik, Department of Virology, OE 5230, Hannover Medical School, Carl-Neuberg-Str. 1, D-30623 Hannover, Germany. Tel.: 49-511-532-2846. Fax: 49-511-532-2827. E-mail: Sodeik.Beate{at}MH-Hannover.de

In this issue, McDonald et al. describe the itinerary of the incoming human immunodeficiency virus (HIV)* during its travels to the host nucleus. They show that subviral particles tagged with the green fluorescent protein (GFP) are propelled along microtubules (MTs) by minus-end–directed and presumably plus-end–directed MT motors. The tracked particles correspond to functional units, since they no longer include a viral envelope, but do include viral matrix protein, Vpr, capsid protein, and reverse transcription activity.


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